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IN VIVO STUDIES OF RADIATION POTENTIATON BY IODOACETAMIDE AND OBSERVATIONS ON TUMOR TRANSPLANTATION IMMUNITY
Iodoacetamide has been shown by others to be a radiation sensitizer for bacteria and for certain mammalian cells tested in vitro. This work describes an examination of the effectiveness of iodoacetamide used in vivo. Survival of ascites tumor cells maintained in the peritoneal cavity of mice was used as an indicator of sensitization. Survival was assessed using TD{sub 50} and total tumor cell population determination methods. A comparison of results obtained by these methods is made. The effects of oxygen tension and radiation dose rate upon results was examined. Iodoacetamide was found to be effective as a radiation sensitizer under all conditions although to a lesser degree than that reported by others for in vitro experiments with bacteria. Radioactive tracer studies indicate that iodoacetamide has rapid and total access to most if not all tissues of the body. This fact coupled with the observation of a sensitization in an in vivo system where the anoxia so prevalent in well developed tumors was present, suggests the possibility of clinical usefulness of iodoacetamide in cancer radiation therapy. Certain observations are reported on the effect of various cell and host treatment procedures upon cell population growth kinetics seen subsequent to inoculation of hosts …
Date:
October 1, 1970
Creator:
Richards, F. Robert & Kelly, Lola S.
System:
The UNT Digital Library
TWO REGGEON EXCHANGE CONTRIBUTIONS TO HADRON SCATTERING AMPLITUDES AT HIGH ENERGY.
None
Date:
January 1, 1970
Creator:
Quigg, C.
System:
The UNT Digital Library
THEORETICAL FOUNDATIONS OF NATURAL AND MAGNETICALLY-INDUCED OPTICAL ACTIVITY.
None
Date:
January 1, 1970
Creator:
Downie, D. E.
System:
The UNT Digital Library
THE MESON SPECTRUM IN THE REACTION PP $Yields$ d MM.
None
Date:
January 1, 1970
Creator:
Wicklund, A. B.
System:
The UNT Digital Library
GAMMA RAY SPECTROSCOPIC STUDIES OF STATES IN NEUTRON-DEFICIENT Pb AND Tl ISOTOPES.
None
Date:
January 1, 1970
Creator:
Doebler, R.E.
System:
The UNT Digital Library
STUDY OF DIPIONS IN THE MASS RANGE 400 TO 1000 MeV PRODUCED IN $pi$$sup -$p COLLISIONS.
None
Date:
January 1, 1970
Creator:
Rangaswamy, T. N.
System:
The UNT Digital Library
Climb of Dislocations in Magnesium Oxide Single Crystals
The wave like pattern, observed in dislocation dipoles of uniform spacing during annealing, which starts from the ends of the dipole and gets damped toward the centre, has been attributed to controlled vacancy migration. A theory has been set-up to give activation energy for the process, 60,700 + 2,000 cal/mole. This value has been compared with an independent study of pipe diffusion, in which a prismatic loop inside the foil is connect to both surfaces of the foil by screw dislocation.
Date:
September 1, 1970
Creator:
Narayan, Jagdish
System:
The UNT Digital Library
Coupling Between Pressure and Temperature Waves in Liquid Helium.
None
Date:
January 1, 1970
Creator:
Fritz, G. F.
System:
The UNT Digital Library
ROTATIONAL PERTURBATIONS AND LOW-LYING ELECTRONIC STATES OF CaO.
None
Date:
January 1, 1970
Creator:
Johansen, H.
System:
The UNT Digital Library
DIFFUSION STUDIES IN THE ALUMINA--SILICA SYSTEM.
None
Date:
January 1, 1970
Creator:
Davis, R.F.
System:
The UNT Digital Library
CHEMISTRY OF STANNANE.
None
Date:
January 1, 1970
Creator:
Webster, J. R.
System:
The UNT Digital Library
MASS SPECTROMETRIC STUDIES OF GASEOUS OXIDES OF RHENIUM AND OF THE LANTHANIUM TRIFLUORIDE DIMER.
None
Date:
January 1, 1970
Creator:
Skinner, H.B.
System:
The UNT Digital Library
Investigation of Fast Neutron Radiation Damage in an Austenitic Stainless Steel.
None
Date:
January 1, 1970
Creator:
Bloom, E. E.
System:
The UNT Digital Library
Strange Particle Production in $Pi$$Sup +$P Interactions Near 3.7 Gev/C.
None
Date:
January 1, 1970
Creator:
Butler, W. R.
System:
The UNT Digital Library
BIOPHYSICAL STUDIES OF SPERMATOZOA.
None
Date:
January 1, 1970
Creator:
Pistenma, D.A.
System:
The UNT Digital Library
THE RADIOACTIVE DECAY OF $sup 168$Ho AND $sup 169$Ho.
None
Date:
January 1, 1970
Creator:
Haustein, P. E.
System:
The UNT Digital Library
STANDARDIZATION OF CONTROL POINT REALIZATION. Report No. 400.
None
Date:
January 1, 1970
Creator:
Martin, R G
System:
The UNT Digital Library
STUDY OF SLIP BAND GROWTH IN PRESTRAINED COPPER.
None
Date:
January 1, 1970
Creator:
Kosel, T. H.
System:
The UNT Digital Library
STRESS CORROSION CRACKING OF A TRIP STEEL.
None
Date:
January 1, 1970
Creator:
Birat, J.
System:
The UNT Digital Library
SOME OBSERVATIONS CONCERNING THE USE OF REALISTIC FORCES IN A MICROSCOPIC DESCRIPTION OF THE INELASTIC SCATTERING OF NUCLEONS FROM NUCLEI AT MEDIUM ENERGIES.
None
Date:
January 1, 1970
Creator:
Petrovich, Fred L
System:
The UNT Digital Library
MAGNETIC FORM FACTOR OF THULIUM AND TERBIUM METALS.
None
Date:
January 1, 1970
Creator:
Brun, T O
System:
The UNT Digital Library
FAR INFRARED STUDIES OF SOLIDS: I. ELECTRONIC LEVELS OF d$sup 1$IONS IN Al$sub 2$O$sub 3$. II. PHONON CONTRIBUTION TO ELECTROMAGNETIC ABSORPTION IN LEAD.
None
Date:
January 1, 1970
Creator:
Joyce, R.R.
System:
The UNT Digital Library
ELECTRONIC STRUCTURE AND DIELECTRIC PROPERTIES OF CUBIC SEMICONDUCTORS.
None
Date:
January 1, 1970
Creator:
Walker, J. P.
System:
The UNT Digital Library
PRECIPITATION IN HIGH PURITY SILICON SINGLE CRYSTALS.
None
Date:
January 1, 1970
Creator:
Nes, A.E.
System:
The UNT Digital Library