This study is concerned with the nature of the relatively unusual bonding which occurs in organolithium compounds as a direct result of the oligomerization and possible explanations for that bonding.

The original purpose of this investigation was to attempt to apply the coulostatic method directly to a molten salt system. The inability to duplicate the reported capacity data for this system resulted in an investigation of the probable cause of this discrepancy between the data obtained by these different methods (14, 15).

The study herein described involved the detection of pyridine N-oxide reductase activity in cell-free extracts of E. coli 9723, the determination of co-factors necessary for the enzymatic process, a study of the optimum conditions for enzyme catalysis, and a general characterization of the enzyme.

The study reported herein concerns itself with the isolation of melaninless mutants of S. antibioticus, ATCC, 3723, and with the demonstration that at least one of the sites of mutation involves that of the enzyme, tyrosinase.

Organolitnium compounds have been employed in synthetic worK for many years. However only during the last decade has much progress been made in establishing the mechanistic pathways for the reactions of these compounds.

Copper(II) and oxovanadium(IV) ions resemble one another magnetically in having one unpaired electron in their complexes irrespective of their geometrical structures and bond types involved. Copper(II) complexes with antiferromagnetic exchange are well known. On the contrary, antiferromagnetic exchange in oxovanadium(IV) complexes is rather new and not well established. Very few oxovanadium(IV) complexes have been reported to have this anomalous magnetic property. In the investigation of the magnetic properties of oxovanadium(IV) complexes, we have successfully prepared two series of new oxovanadium(IV) complexes with N-salicylideneamino acids.

In many series of compounds, intensity of biological activity and chemical reactivity are proportional. Generally whenever a alkyl group replaces a reactive hydrogen atom, as would be the case for an N-substituted hydroxylamine as compared to hydroxylamine, the over-all biological activity of the resulting compound is lower than that of its nonalkylated analogue. Since toxicity and physiological activity are not proportional, this comparison can only suggest possible types of derivatives to prepare and test.