Automated Insertion of Sequences into a Ribosomal RNA Alignment: an Application of Computational Linguistics in Molecular Biology (open access)

Automated Insertion of Sequences into a Ribosomal RNA Alignment: an Application of Computational Linguistics in Molecular Biology

This thesis involved the construction of (1) a grammar that incorporates knowledge on base invariancy and secondary structure in a molecule and (2) a parser engine that uses the grammar to position bases into the structural subunits of the molecule. These concepts were combined with a novel pinning technique to form a tool that semi-automates insertion of a new species into the alignment for the 16S rRNA molecule (a component of the ribosome) maintained by Dr. Carl Woese`s group at the University of Illinois at Urbana. The tool was tested on species extracted from the alignment and on a group of entirely new species. The results were very encouraging, and the tool should be substantial aid to the curators of the 16S alignment. The construction of the grammar was itself automated, allowing application of the tool to alignments for other molecules. The logic programming language Prolog was used to construct all programs involved. The computational linguistics approach used here was found to be a useful way to attach the problem of insertion into an alignment.
Date: November 1991
Creator: Taylor, Ronald C.
System: The UNT Digital Library
Proceedings of the Workshop on Compilation of (Symbolic) Languages for Parallel Computers  : Held October 31 - November 1, 1991, San Diego, CA (open access)

Proceedings of the Workshop on Compilation of (Symbolic) Languages for Parallel Computers : Held October 31 - November 1, 1991, San Diego, CA

This report comprises the abstracts and papers for the talks presented at the Workshop on Compilation of (Symbolic) Languages for Parallel Computers, held October 31 - November 1, 1991, in San Diego. These unrefereed contributions were provided by the participants for the purpose of this workshop; many of them will be published elsewhere in peer-reviewed conferences and publications.
Date: November 1991
Creator: Foster, Ian & Tick, Evan
System: The UNT Digital Library
Radiation Chemistry of Synthetic Waste (open access)

Radiation Chemistry of Synthetic Waste

The yield of hydrogen from radiolysis of aqueous solutions is substantially reduced by the presence of nitrate and nitrite in the waste solutions. Nitrate is more efficient in scavenging the precursors to hydrogen than is nitrite, therefore, the latter should be maintained at higher levels if minimization of radiolytic gas production is required. Nitrate is the major scavenger for e(sub aq)(sup (minus)) and nitrite is the major scavenger for H atoms. At the concentration levels of the waste solutions some fraction of the radiation energy will be absorbed directly by the solutes, primarily the nitrate/nitrite components. Organic additive will increase the generation of hydrogen and mechanistic information is available to allow predictive modeling of trends in the rate of the generation. Physical parameters such as temperature, viscosity, and pressure will not significantly affect the gas generation relative to its generation under normal conditions. Radiolytic generation of N2O is very inefficient in the absence of organic solutes. No mechanistic information is available on its generation in the presence of organic additives. At the concentration levels of the inorganic salts in the waste solutions, it will be very difficult to find a chemical additive that could efficiently reduce the yield of the …
Date: November 1991
Creator: Meisel, Dan; Diamond, H.; Horwitz, E. P.; Jonah, Charles D.; Matheson, Max S.; Sauer, M. C. et al.
System: The UNT Digital Library
Computer Analysis of Geochemical Data of Stream Sediment and Waters of the Montrose 1° X 2° Quadrangle, Colorado (open access)

Computer Analysis of Geochemical Data of Stream Sediment and Waters of the Montrose 1° X 2° Quadrangle, Colorado

The following preliminary report is a computer analysis of HSSR data from the Montrose 1x2 Quadrangle, Colorado.
Date: November 25, 1991
Creator: Proctor, Paul Dean
System: The UNT Digital Library