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Transcriptomic profiling of miR-203a inhibitor and miR-34b-injected zebrafish (Danio rerio) validates oil-induced neurological, cardiovascular and eye toxicity response pathways
Article discusses how the global sequencing of microRNA (miRNA; miR) and integration to downstream mRNA expression profiles in early life stages (ELS) of fish following exposure to crude oil determined consistently dysregulated miRNAs regardless of the oil source or fish species. The overlay of differentially expressed miRNAs and mRNAs into in silico software determined that the key roles of these miRNAs were predicted to be involved in cardiovascular, neurological and visually-mediated pathways.
Date:
November 21, 2022
Creator:
Maguson, Jason T.; Leads, Rachel R.; McGruer, Victoria; Qian, Le; Tanabe, Philip; Roberts, Aaron P. et al.
Object Type:
Article
System:
The UNT Digital Library
How Tiny Zebrafish and Their Surprisingly Human-Like Genome Can Benefit Medical Research
Presentation highlighting the use of zebrafish to identify genes relating to predisposition to thromboembolism and cardiovascular disease in people with African ancestry. It was presented at the UNT Transdisciplinary Conference on Ancestral Genomics Research which was held virtually on November 20-21, 2020.
Date:
November 21, 2020
Creator:
Jagadeeswaran, Pudur
Object Type:
Video
System:
The UNT Digital Library