This grant supported the Sixth International Conference on Systems Biology (ICSB 2005), held in Boston, Massachusetts from October 19th to 22nd, 2005. The ICSB is the only major, annual, international conference focused exclusively on the important emerging field of systems biology. It draws together scientists with expertise in theoretical, computational and experimental approaches to understanding biological systems at many levels. Previous ICSB meetings have been held in Tokyo (2000), at Caltech (2001), at the Karolinska Institute (2002), at Washington University in St. Louis (2003), and in Heidelberg (2004). These conferences have been increasingly successful at bringing together the growing community of established and junior researchers with interests in this area. Boston is home to several groups that have shown leadership in the field and was therefore an ideal place to hold this conference . The executive committee for the conference comprised Jim Collins (Biomedical Engineering, Boston University), Marc Kirschner (chair of the new Department of Systems Biology at Harvard Medical School), Eric Lander (director of the Broad Institute of MIT and Harvard), Andrew Murray (director of Harvard’s Bauer Center for Genomics Research) and Peter Sorger (director of MIT’s Computational and Systems Biology Initiative). There are almost as many definitions of …

In this paper we describe how we have used Pin to generate a multithreaded reference stream for simulation of a multiprocessor on a uniprocessor. We have taken special care to model as accurately as possible the effects of cache coherence protocol state, and lock and barrier synchronization on the performance of multithreaded applications running on multiprocessor hardware. We first describe a simplified version of the algorithm, which uses semaphores to synchronize instrumented application threads and the simulator on every memory reference. We then describe modifications to that algorithm to model the microarchitectural features of the Itanium2 that affect the timing of memory reference issue. An experimental evaluation determines that while cycle-accurate multithreaded simulation is possible using our approach, the use of semaphores has a negative impact on the performance of the simulator.

Studies of Photochemically Induced Dynamic Nuclear Polarization in Photosynthetic Bacterial Reaction Centers: Wavelength and Time Dependence Solid-state NMR spectra of quinone-reduced photosynthetic bacterial reaction centers (RCs) and chromatophores exhibit certain strongly enhanced lines under illumination, a result of photochemically induced dynamic nuclear polarization (photo-CIDNP). This technique offers a new method to investigate photosynthetic electronic transactions while retaining the NMR advantages of narrow linewidths and site-specific resolution. Pulsed laser illumination at 532 nm was used as the basis for time resolved photo-CIDNP experiments, a technique not previously published for solid-state photosynthetic systems. These measurements offer insight about the origin of the polarization effects.

Recording of the 24th Annual Dallas Fort Worth Black Tie Dinner, that raises money and awareness for current GLBT/LGBT issues and organizations. The theme of the dinner was "Imagine Tomorrow" and used kaleidoscopes to inspire much of the design. The opening of the video includes directions for finding information about the luxury items up for auction. Bob Eckelcam is the Luxury Auctioneer of the night and early on in the auction Sharon Stone comes on-stage and takes Eckelcam's place as the head auctioneer. Item donors included Natuzzi Dallas, Eiseman Jewels and Cartier, Silverseas, Waterworks, Dallas Harley Davidson, Neiman Marcus, HRC, Hewitt & Habgood Realty Group, and Sharon Stone herself. Following the auction the dinner's co-chairs introduce Eric and Sheryl Maas, owners of Classic BMW, to perform the raffle drawing for a 2006 BMW 325i. At the end Lily Tomlin delivers the closing keynote address and performs a few of her comedy skits.

Photograph of a silent auction table at the 2005 Back Tie Dinner. Items on the table include: several gift baskets, three dresses on mannequin forms, and other clothing items.

Photograph of a man (left) and a woman (right) at the 2005 Black Tie Dinner. They are standing side by side, looking at the camera and smiling. The woman is holding the strap of a purse in her left hand. A Christmas tree can be seen in the background on the left side of the photograph.

Photograph of two women at the 2005 Black Tie Dinner. They are standing side by side, looking at the camera and smiling. The woman on the right is holding the strap of a purse in her left hand. A Christmas tree can be seen in the background on the left side of the photograph.

Photograph of a woman (left) and a man (right) at the 2005 Black Tie Dinner. They are standing side by side, looking at the camera and smiling. The woman is holding a clutch in her left hand.

Photograph of Breggett Rideau (right) performing at the 2005 Black Tie Dinner. Rideau can be seen on stage in the center of the photograph, facing the camera and smiling. She is holding a microphone in her right hand. Two men can be seen on stage behind her, playing bass guitar (left) and piano (center).

Photograph of three men at the 2005 Black tie Dinner. The men are standing side by side, looking at the camera and smiling. They are each holding a drink.

Photograph of two women at the 2005 Black Tie Dinner. They are standing side by side, looking at the camera and smiling. They are each holding a drink. The woman on the right is holding a Hallmark shopping bag in her left hand.

Photograph of two men at the 2005 Black Tie Dinner. They are standing side by side, looking at the camera and smiling. Auction tables can be seen behind them in the background of the photograph.

Photograph of two men (left, 2nd left) and two women (2nd right, right) at the 2005 Black Tie Dinner. Individuals are standing side by side, looking at the camera. Both men and one of the women (2nd right) are smiling.

Photograph of two men at the 2005 Black Tie Dinner. The men are standing side by side, looking at the camera and smiling.

Photograph of Mattie Roberts at the 2005 Black Tie Dinner. Roberts is standing in the center of the photograph, wearing a turquoise mermaid-style dress. She is facing the camera and smiling.

Photograph of four men at the 2005 Black Tie Dinner. They are standing side by side, looking at the camera and smiling. They are all wearing matching boutonnières.

Photograph of four men at the 2005 Black Tie Dinner. They are standing side by side, looking at the camera and smiling. Two of the men (left, 2nd left) are wearing matching boutonnières.

Photograph of two men at the 2005 Black Tie Dinner. The men are standing side by side, looking at the camera and smiling.

Photograph of two men at the 2005 Black Tie Dinner. The men are standing side by side, looking at the camera and smiling. They are each holding a wine glass. Other guests can be seen in the background of the photograph.

Photograph of four men at the 2005 Black Tie Dinner. They are standing side by side, looking at the camera and smiling. Two of the men (2nd left, right) are holding drinks.

Photograph of two men at the 2005 Black Tie Dinner. The men are standing side by side, looking at the camera and smiling. They are each holding a drink.

Photograph of four men at the 2005 Black Tie Dinner. The men are standing side by side, looking at the camera and smiling.

Photograph of Kathy Hewitt (left) and Anne Fay (right) at the 2005 Black Tie Dinner. The women are standing side by side, looking at the camera and smiling.

Photograph of Mattie Roberts speaking at the 2005 Black Tie Dinner cocktail reception. Roberts can be seen in the center of the photograph, looking to the right of the camera. She is holding a microphone in her right hand and a sheet of paper in her left.