According to the Administration's "National Security Strategy" document released on March 16, 2006, the United States "may face no greater challenge from a single country than Iran." To date, the Bush Administration has pursued several avenues to attempt to contain the potential threat posed by Iran, including supporting a long-term policy of changing Iran's regime. Iran's nuclear program is not the only major U.S. concern on Iran. Successive administrations have pointed to the threat posed by Iran's policy in the Near East region, particularly material support to groups that use violence to prevent or complicate Israeli-Arab peace. Iran's human rights practices and strict limits on free expression have been consistently criticized by official U.S. and U.N. reports.

Report discussing U.S. concerns with Iran, including concerns relating to endorsements given to terrorist organizations by the Iranian government, nuclear weaponry, and human rights practices.