Formation of vapor bubbles is characteristic of many applications of short-pulse lasers in medicine. An understanding of the dynamics of vapor bubble generation is useful for developing and optimizing laser-based medical therapies. To this end, experiments in vapor bubble generation with laser light deposited in an aqueous dye solution near a fiber-optic tip have been performed. Numerical hydrodynamic simulations have been developed to understand and extrapolate results from these experiments. Comparison of two-dimensional simulations with the experiment shows excellent agreement in tracking the bubble evolution. Another regime of vapor bubble generation is short-pulse laser interactions with melanosomes. Strong shock generation and vapor bubble generation are common physical features of this interaction. A novel effect of discrete absorption by melanin granules within a melanosome is studied as a possible role in previously reported high Mach number shocks.

In 1986, Congress directed the U.S. Environmental Protection Agency (EPA) to establish a national inventory of toxic releases to the environment by manufacturing facilities and to use the inventory to inform the public about chemicals used and released in their communities. Since enactment of the Emergency Planning and Community Right-to-Know Act (EPCRA) more than 10 years ago, manufacturers have been required to report releases of hundreds of hazardous chemicals annually. EPA compiles the reported information into the Toxics Release Inventory (TM) and distributes it in various written and electronic forms.