Ulcerative colitis (UC) is a chronic inflammatory disease characterized by periods of relapses and remissions affecting more than 500,000 people in the United States. To achieve the therapeutic goals of UC, which are to first induce and then maintain disease remission, doctors need to evaluate the severity of UC of a patient. However, it is very difficult to evaluate the severity of UC objectively because of non-uniform nature of symptoms and large variations in their patterns. To address this, in our previous works, we developed two different approaches in which one is using the image textures, and the other is using CNN (convolutional neural network) to measure and classify objectively the severity of UC presented in optical colonoscopy video frames. But, we found that the image texture based approach could not handle larger number of variations in their patterns, and the CNN based approach could not achieve very high accuracy. In this paper, we improve our CNN based approach in two ways to provide better accuracy for the classification. We add more thorough and essential preprocessing, and generate more classes to accommodate large variations in their patterns. The experimental results show that the proposed preprocessing can improve the overall accuracy …

Vehicular ad-hoc networks (VANETs) are used for vehicle-to-vehicle (V2V) and vehicle-to-infrastructure (V2I) communications. The IEEE 802.11p/WAVE (Wireless Access in Vehicular Environment) and with WAVE Short Messaging Protocol (WSMP) has been proposed as the standard protocol for designing applications for VANETs. This communication protocol must be thoroughly tested before reliable and efficient applications can be built using its protocols. In this paper, we perform on-road experiments in a variety of scenarios to evaluate the performance of the standard. We use commercial VANET devices with 802.11p/WAVE compliant chipsets for both BSM (basic safety messages) as well as video streaming applications using WSMP as a communication protocol. We show that while the standard performs well for BSM application in lightly loaded conditions, the performance becomes inferior when traffic and other performance metric increases. Furthermore, we also show that the standard is not suitable for video streaming due to the bursty nature of traffic and the bandwidth throttling, which is a major shortcoming for V2X applications.

With an ever-growing number of publications in the biomedical domain, it becomes likely that important implicit connections between individual concepts of biomedical knowledge are overlooked. Literature based discovery (LBD) is in practice for many years to identify plausible associations between previously unrelated concepts. In this paper, we present a new, completely automatic and interactive system that creates a graph-based knowledge base to capture multifaceted complex associations among biomedical concepts. For a given pair of input concepts, our system auto-generates a list of ranked subgraphs uncovering possible previously unnoticed associations based on context information. To rank these subgraphs, we implement a novel ranking method using the context information obtained by performing random walks on the graph. In addition, we enhance the system by training a Neural Network Classifier to output the likelihood of the two concepts being likely related, which provides better insights to the end user.

The purpose of telecommunication network configuration optimization is to find the best homing relationship between tandems and switches so as to minimize interswitch traffic, or equivalently to maximize intraswitch traffic. Note that, since minimal interswitch traffic implies minimal IMT utilization, communication costs will also be minimal.

This problem is intended to be an introduction to the design of a software system which translates PDP-8 assembly language source into it's machine-readable object code. This assembler runs on the IBM 360/50. It is assumed that the reader is familiar with the basic PDP-8 assembly language. For the description and use of this assembler the reader is referred to the PAL-III SYMBOLIC ASSEMBLER PROGRAMMING MANUAL from DEC (order number DIGITAL 8-3-5, Digital Equipment Corporation: Maynard, Massachusetts, 1965.). The Second problem of the study concerns the design of a simulator for the PDP-8 computer.

The purpose of this project is 1) to create a Thai character set for text processing, 2) to write a text processing program for the character set, and 3) to allow users to create and save the text.

This is a report concerning the project I completed for my 590 (special problem) credit. The subject of this project was a system for interactive practice room scheduling by music students at NTSU. This system was created in the fall semester of 1982 as a class project for software Development (CSCI 553) with Dr. Irby. The system was not completely finished, and I received permission from Dr. Irby to finish it and help implement its use at the Music department. I was able to observe three usages of the system: Spring, Summer I, and Summer II semesters of 1983. This report details the problems encountered during each of these usages, and changes made to the system due to them. Results of a first-use survey, under documentation, and complete final code listings were also included.

The objective of this work is to help the faculty, staffs and students of NTSU to use the CalComp plotting facility very easily. Therefore, this work is written in such a step by step and self-explanatory way to help the reader to understand and grasp the essential technique of the computer plotting. Each subroutine illustrated in this work has been run and checked by our NTSU computer-CalComp plotting facility; the results of sample programs and illustrated graphs are believed to be very useful to understand each individual subroutine. Basically, software packages are stored in the magnetic disk of the IBM 360 computer as the standard graphic subroutines. These subroutines were written in FORTRAN IV. The user can write the driving program to call these subroutines and also inputs the desire data to the computer for computation. The results of computation will be outputed and stored in the magnetic tape.

PILOT (Programmed Inquiry, Learning or Teaching) is a simple, conversational language developed in 1969 by John A. Starkweather at the University of California Medical Center in San Francisco. Originally designed for computer assisted instructional needs, PILOT also has been effectively used as an introductory computer language. The PILOT system developed for the Apple II microcomputer consists of two programs, PILOT EDITOR and PILOT DRIVER, which are written in Applesoft and which use the Apple II disk operating system. The PILOT system was designed to facilitate easy authoring and execution of programs written in an extended version of the PILOT language. Due to the memory requirements of the programs and the Apple II disk operating system, the PILOT system described here should be executed on a machine with at least 32k bytes of random access memory.

Among the early applications of computers, one can find frequent mention of intelligent instructional systems. Such intelligent instructional systems represent a new generation of learner-based computer aided instruction, preceded in time by the original frame-based systems and an intervening generation of expert-based CAI. The history of CAI is characterized by three generations: Frame-based CAI, Expert-based CAI and Learner-based CAI.

The author's primary goal is to begin research leading ot the attainment of a low cost computer/music system which will allow the composer to write polyphonic music of up to eight voices into a computer through a terminal, and have the music played back by means of computer synthesized sound or by means of a conventional synthesizer controlled by a computer via digital-to-analog converters. The goal system will allow the composer to retreat and hear his product objectively as the painter steps back to review his canvas.

In developing countries, acute respiratory infections (ARIs) are responsible for two million deaths per year. Most victims are children who are less than 5 years old. Pneumonia kills 5000 children per day. The statistics for cardiovascular diseases (CVDs) are even more alarming. According to a 2009 report from the World Health Organization (WHO), CVDs kill 17 million people per year. In many resource-poor parts of the world such as India and China, many people are unable to access cardiologists, pulmonologists, and other specialists. Hence, low skilled health professionals are responsible for screening people for ARIs and CVDs in these areas. For example, in the rural areas of the Philippines, there is only one doctor for every 10,000 people. By contrast, the United States has one doctor for every 500 Americans. Due to advances in technology, it is now possible to use a smartphone for audio recording, signal processing, and machine learning. In my thesis, I have developed an Android application named Smart Auscultation. Auscultation is a process in which physicians listen to heart and lung sounds to diagnose disorders. Cardiologists spend years mastering this skill. The Smart Auscultation application is capable of recording and classifying heart sounds, and can be …

The history of mitigation programs to contain vector-borne diseases is a story of successes and failures. Due to the complex interplay among multiple factors that determine disease dynamics, the general principles for timely and specific intervention for incidence reduction or eradication of life-threatening diseases has yet to be determined. This research discusses computational methods developed to assist in the understanding of complex relationships affecting vector-borne disease dynamics. A computational framework to assist public health practitioners with exploring the dynamics of vector-borne diseases, such as malaria and dengue in homogenous and heterogeneous populations, has been conceived, designed, and implemented. The framework integrates a stochastic computational model of interactions to simulate horizontal disease transmission. The intent of the computational modeling has been the integration of stochasticity during simulation of the disease progression while reducing the number of necessary interactions to simulate a disease outbreak. While there are improvements in the computational time reducing the number of interactions needed for simulating disease dynamics, the realization of interactions can remain computationally expensive. Using multi-threading technology to improve performance upon the original computational model, multi-threading experimental results have been tested and reported. In addition, to the contact model, the modeling of biological processes specific to …

Network security is a complex field that is handled by security professionals who need certain expertise and experience to configure security systems. With the ever increasing size of the networks, managing them is going to be a daunting task. What kind of solution can be used to generate effective security configurations by both security professionals and nonprofessionals alike? In this thesis, a web tool is developed to simplify the process of configuring security systems by translating direct human language input into meaningful, working security rules. These human language inputs yield the security rules that the individual wants to implement in their network. The human language input can be as simple as, "Block Facebook to my son's PC". This tool will translate these inputs into specific security rules and install the translated rules into security equipment such as virtualized Cisco FWSM network firewall, Netfilter host-based firewall, and Snort Network Intrusion Detection. This tool is implemented and tested in both a traditional network and a cloud environment. One thousand input policies were collected from various users such as staff from UNT departments' and health science, including individuals with network security background as well as students with a non-computer science background to analyze …

Managing large-scale dynamical systems (e.g., transportation systems, complex information systems, and power networks, etc.) in real-time is very challenging considering their complicated system dynamics, intricate network interactions, large scale, and especially the existence of various uncertainties. To address this issue, intelligent techniques which can quickly design decision-making strategies that are robust to uncertainties are needed. This dissertation aims to conquer these challenges by exploring a data-driven decision-making framework, which leverages big-data techniques and scalable uncertainty evaluation approaches to quickly solve optimal control problems. In particular, following techniques have been developed along this direction: 1) system modeling approaches to simplify the system analysis and design procedures for multiple applications; 2) effective simulation and analytical based approaches to efficiently evaluate system performance and design control strategies under uncertainty; and 3) big-data techniques that allow some computations of control strategies to be completed offline. These techniques and tools for analysis, design and control contribute to a wide range of applications including air traffic flow management, complex information systems, and airborne networks.

POD (Point of Dispensing)-based emergency response plans involving mass prophylaxis may seem feasible when considering the choice of dispensing points within a region, overall population density, and estimated traffic demands. However, the plan may fail to serve particular vulnerable sub-populations, resulting in access disparities during emergency response. Federal authorities emphasize on the need to identify sub-populations that cannot avail regular services during an emergency due to their special needs to ensure effective response. Vulnerable individuals require the targeted allocation of appropriate resources to serve their special needs. Devising schemes to address the needs of vulnerable sub-populations is essential for the effectiveness of response plans. This research focuses on data-driven computational methods to quantify and address vulnerabilities in response plans that require the allocation of targeted resources. Data-driven methods to identify and quantify vulnerabilities in response plans are developed as part of this research. Addressing vulnerabilities requires the targeted allocation of appropriate resources to PODs. The problem of resource allocation to PODs during public health emergencies is introduced and the variants of the resource allocation problem such as the spatial allocation, spatio-temporal allocation and optimal resource subset variants are formulated. Generating optimal resource allocation and scheduling solutions can be computationally hard …

Computer security attacks take place due to the presence of vulnerabilities and bugs in software applications. Bugs and vulnerabilities are the result of weak software architecture and lack of standard software development practices. Despite the fact that software companies are investing millions of dollars in the research and development of software designs security risks are still at large. In some cases software applications are found to carry vulnerabilities for many years before being identified. A recent such example is the popular Heart Bleed Bug in the Open SSL/TSL. In today’s world, where new software application are continuously being developed for a varied community of users; it’s highly unlikely to have software applications running without flaws. Attackers on computer system securities exploit these vulnerabilities and bugs and cause threat to privacy without leaving any trace. The most critical vulnerabilities are those which are related to the integrity of the software applications. Because integrity is directly linked to the credibility of software application and data it contains. Here I am giving solution of maintaining web applications integrity running on RADIUM by using daikon. Daikon generates invariants, these invariants are used to maintain the integrity of the web application and also check the …

Optical character recognition (OCR) software has advanced greatly in recent years. Machine-printed text can be scanned and converted to searchable text with word accuracy rates around 98%. Reasonably neat hand-printed text can be recognized with about 85% word accuracy. However, cursive handwriting still remains a challenge, with state-of-the-art performance still around 75%. Algorithms based on hidden Markov models have been only moderately successful, while recurrent neural networks have delivered the best results to date. This thesis explored the feasibility of using a special type of feedforward neural network to convert freeform cursive handwriting to searchable text. The hidden nodes in this network were grouped into clusters, with each cluster being trained to recognize a unique character bigram. The network was trained on writing samples that were pre-segmented and annotated. Post-processing was facilitated in part by using the network to identify overlapping bigrams that were then linked together to form words and sentences. With dictionary assisted post-processing, the network achieved word accuracy of 66.5% on a small, proprietary corpus. The contributions in this thesis are threefold: 1) the novel clustered architecture of the feed-forward neural network, 2) the development of an expanded set of observers combining image masks, modifiers, and feature …

Shadows in indoor scenarios are usually characterized with multiple light sources that produce complex shadow patterns of a single object. Without removing shadow, the foreground object tends to be erroneously segmented. The inconsistent hue and intensity of shadows make automatic removal a challenging task. In this thesis, a dynamic thresholding and transfer learning-based method for removing shadows is proposed. The method suppresses light shadows with a dynamically computed threshold and removes dark shadows using an online learning strategy that is built upon a base classifier trained with manually annotated examples and refined with the automatically identified examples in the new videos. Experimental results demonstrate that despite variation of lighting conditions in videos our proposed method is able to adapt to the videos and remove shadows effectively. The sensitivity of shadow detection changes slightly with different confidence levels used in example selection for classifier retraining and high confidence level usually yields better performance with less retraining iterations.

In recent years, the collection of genomic data has skyrocketed and databases of genomic data are growing at a faster rate than ever before. Although many computational methods have been developed to interpret these data, they tend to struggle to process the ever increasing file sizes that are being produced and fail to take advantage of the advances in multi-core processors by using parallel processing. In some instances, loss of accuracy has been a necessary trade off to allow faster computation of the data. This thesis discusses one such algorithm that has been developed and how changes were made to allow larger input file sizes and reduce the time required to achieve a result without sacrificing accuracy. An information entropy based algorithm was used as a basis to demonstrate these techniques. The algorithm dissects the distinctive patterns underlying genomic data efficiently requiring no a priori knowledge, and thus is applicable in a variety of biological research applications. This research describes how parallel processing and object-oriented programming techniques were used to process larger files in less time and achieve a more accurate result from the algorithm. Through object oriented techniques, the maximum allowable input file size was significantly increased from 200 …

Trusted Computing capability has become ubiquitous these days, and it is being widely deployed into consumer devices as well as enterprise platforms. As the number of threats is increasing at an exponential rate, it is becoming a daunting task to secure the systems against them. In this context, the software integrity measurement at runtime with the support of trusted platforms can be a better security strategy. Trusted Computing devices like TPM secure the evidence of a breach or an attack. These devices remain tamper proof if the hardware platform is physically secured. This type of trusted security is crucial for forensic analysis in the aftermath of a breach. The advantages of trusted platforms can be further leveraged if they can be used wisely. RADIUM (Race-free on-demand Integrity Measurement Architecture) is one such architecture, which is built on the strength of TPM. RADIUM provides an asynchronous root of trust to overcome the TOC condition of DRTM. Even though the underlying architecture is trusted, attacks can still compromise applications during runtime by exploiting their vulnerabilities. I propose an application-level integrity measurement solution that fits into RADIUM, to expand the trusted computing capability to the application layer. This is based on the concept …

The basis of today’s security systems is the trust and confidence that the system will behave as expected and are in a known good trusted state. The trust is built from hardware and software elements that generates a chain of trust that originates from a trusted known entity. Leveraging hardware, software and a mandatory access control policy technology is needed to create a trusted measurement environment. Employing a control layer (hypervisor or microkernel) with the ability to enforce a fine grained access control policy with hyper call granularity across multiple guest virtual domains can ensure that any malicious environment to be contained. In my research, I propose the use of radium's Asynchronous Root of Trust Measurement (ARTM) capability incorporated with a secure mandatory access control policy engine that would mitigate the limitations of the current hardware TPM solutions. By employing ARTM we can leverage asynchronous use of boot, launch, and use with the hypervisor proving its state and the integrity of the secure policy. My solution is using Radium (Race free on demand integrity architecture) architecture that will allow a more detailed measurement of applications at run time with greater semantic knowledge of the measured environments. Radium incorporation of a …

Email connects 85% of the world. This paper explores the pattern of information overload encountered by majority of email users and examine what steps key email providers are taking to combat the problem. Besides fighting spam, popular email providers offer very limited tools to reduce the amount of unwanted incoming email. Rather, there has been a trend to expand storage space and aid the organization of email. Storing email is very costly and harmful to the environment. Additionally, information overload can be detrimental to productivity. We propose a simple solution that results in drastic reduction of unwanted mail, also known as graymail.

One of the challenges fairly common in motivational interviewing is patient resistance to health behavior change. Hence, automated dialog systems aimed at counseling patients need to be capable of detecting resistance and appropriately altering dialog. This thesis focusses primarily on the development of such a system for automatic identification of patient resistance to behavioral change. This enables the dialogue system to direct the discourse towards a more agreeable ground and helping the patient overcome the obstacles in his or her way to change. This thesis also proposes a dialogue system framework for health behavior change via natural language analysis and generation. The proposed framework facilitates automated motivational interviewing from clinical psychology and involves three broad stages: rapport building and health topic identification, assessment of the patient’s opinion about making a change, and developing a plan. Using this framework patients can be encouraged to reflect on the options available and choose the best for a healthier life.