Degree Department
1 Matching Results
Results open in a new window/tab.
Results:
1 - 1 of
1
A gene based approach to test genetic association based on an optimally weighted combination of multiple traits
In this article, the authors propose a statistical method by Testing an Optimally Weighted Combination of Multiple traits (TOW-CM) to test the association between multiple traits and multiple variants in a genomic region (a gene or pathway). They investigate the performance of the proposed method through extensive simulation studies. Their simulation studies show that the proposed method has correct type I error rates and is either the most powerful test or comparable with the most powerful tests. Additionally, they illustrate the usefulness of TOW-CM based on a COPDGene study.
Date:
August 9, 2019
Creator:
Zhang, Jianjun; Sha, Qiuying; Liu, Guanfu & Wang, Xuexia
System:
The UNT Digital Library