Article on the role of hypoxia in the evolution and development of the cardiovascular system.

Article discussing the linear free energy relationship correlations for enthalpies of solvation of organic solutes into room-temperature ionic liquids based on the Abraham model with ion-specific equation coefficients.

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Computers transfer data in a number of different ways. Whether through a serial port, a parallel port, over a modem, over an ethernet cable, or internally from a hard disk to memory, some data will be lost. To compensate for that loss, numerous error detection and correction algorithms have been developed. One of the most common error correction codes is the Reed-Solomon code, which is a special subset of BCH (Bose-Chaudhuri-Hocquenghem) linear cyclic block codes. In the AURA project, an unmanned aircraft sends the data it collects back to earth so it can be analyzed during flight and possible flight modifications made. To counter possible data corruption during transmission, the data is encoded using a multi-block Reed-Solomon implementation with a possibly shortened final block. In order to maximize the amount of data transmitted, it was necessary to reduce the computation time of a Reed-Solomon encoding to three percent of the processor's time. To achieve such a reduction, many code optimization techniques were employed. This paper outlines the steps taken to reduce the processing time of a Reed-Solomon encoding and the insight into modern optimization techniques gained from the experience.

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Fast Z-pinch technology developed on the Z machine at Sandia National Laboratories can produce up to 230 TW of thermal x-ray power for applications in inertial confinement fusion (ICF) and weapons physics experiments. During implosion, these Z-pinches develop Rayleigh-Taylor (R-T) instabilities which are very difficult to diagnose and which functionally diminish the overall pinch quality. The Power-Space-Time (PST) instrument is a newly configured diagnostic for measuring the pinch power as a function of both space and time in a Z-pinch. Placing the diagnostic at 90 degrees from the Z-pinch axis, the PST provides a new capability in collecting experimental data on R-T characteristics for making meaningful comparisons to magneto-hydrodynamic computer models. This paper is a summary of the PST diagnostic design. By slit-imaging the Z-pinch x-ray emissions onto a linear scintillator/fiber-optic array coupled to a streak camera system, the PST can achieve {approximately}100 {micro}m spatial resolution and {approximately}1.3 ns time resolution. Calculations indicate that a 20 {micro}m thick scintillating detection element filtered by 1,000 {angstrom} of Al is theoretically linear in response to Plankian x-ray distributions corresponding to plasma temperatures from 40 eV to 150 eV, By calibrating this detection element to x-ray energies up to 5,000 eV, the PST …

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Thermal and its resulting mechanical stress due to quenches inside the Epoxy impregnated Nb{sub 3}Sn high field magnets are studied with a combination of a quench simulation program, and ANSYS program. We use the geometry of the high field cosine theta type dipole magnets with one meter and 10 meter length. The turns, where quenches started, are excessively heated up, up to 100 K to 300 K, depending on the coil length and time delay. The non quenching turns and surrounding material are not heated substantially. This elevated temperature and its gradient cause the excessive local stress in the quenching conductors and their insulation material. The stress and strain in the conductor as well as in the insulation become excessive, and they are studied using the ANSYS stress analysis.

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Oak Ridge National Laboratory (ORNL) has recently installed both a Compaq AlphaServer SC and an IBM SP, each with 4-way SMP nodes, allowing a direct comparison of the two architectures. In this paper, we describe our initial evaluation. The evaluation looks at both kernel and application performance for a spectral atmospheric general circulation model, an important application for the ORNL systems.

In recent years exciting experimental discoveries have shown that neutrino flavors oscillate, and hence that neutrinos have nonzero masses and mixings. The Standard Model needs to be modified to accommodate neutrino mass terms, which require either the existence of right-handed neutrinos to create Dirac mass terms, and/or a violation of lepton number conservation to create Majorana mass terms. The observation that neutrino masses and mass-splittings are tiny compared to the masses of any of the other fundamental fermions suggests radically new physics, which perhaps originates at the GUT or Planck Scale, or perhaps indicates the existence of new spatial dimensions. Whatever the origin of the observed neutrino masses and mixings is, it will certainly require a profound extension to our picture of the physical world. The first step towards understanding this new physics is to pin down the measurable parameters, and address the first round of basic questions: (1) Are there only three neutrino flavors, or do light sterile neutrinos exist? Are there any other deviations to three-flavor mixing? (2) There is one angle {theta}{sub 13} in the mixing matrix which is unmeasured. Is it non-zero? (3) We don't know the mass-ordering of the neutrino mass eigenstates. There are two …

A description is given of the analytic and numerical work, performed from July 1955 through August 1956, so as to develop, and then study, the process of making intense proton beams, suitable for colliding beams. It is shown how this investigation led, in a most natural way, to the realization that stochasticity can arise in a simple Hamiltonian system. Furthermore, the criterion for the onset of stochasticity was understood, and carefully studied, in two different situations. The first situation was the proposed (and subsequently used) ''stacking process'' for developing an intense beam, where stochasticity occurs as additional particles are added to the intense circulating beam. The second situation occurs when one seeks to develop ''stochastic accelerators'' in which particles are accelerated (continuously) by a collection of radio frequency systems. It was in the last connection that the well-known criterion for stochasticity, resonance overlap, was obtained.

The determination of regional attenuation Q{sup -1} can depend upon the analysis method employed. The discrepancies between methods are due to differing parameterizations (e.g., geometrical spreading rates), employed datasets (e.g., choice of path lengths and sources), and the methodologies themselves (e.g., measurement in the frequency or time domain). Here we apply five different attenuation methodologies to a Northern California dataset. The methods are: (1) coda normalization (CN), (2) two-station (TS), (3) reverse two-station (RTS), (4) source-pair/receiver-pair (SPRP), and (5) coda-source normalization (CS). The methods are used to measure Q of the regional phase, Lg (Q{sub Lg}), and its power-law dependence on frequency of the form Q{sub 0}f{sup {eta}} with controlled parameterization in the well-studied region of Northern California using a high-quality dataset from the Berkeley Digital Seismic Network. We investigate the difference in power-law Q calculated among the methods by focusing on the San Francisco Bay Area, where knowledge of attenuation is an important part of seismic hazard mitigation. This approximately homogeneous subset of our data lies in a small region along the Franciscan block. All methods return similar power-law parameters, though the range of the joint 95% confidence regions is large (Q{sub 0} = 85 {+-} 40; {eta} = …

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Hyperpolarized 129Xe NMR can detect the presence of specific low-concentration biomolecular analytes by means of the xenon biosensor, which consists of a water-soluble, targeted cryptophane-A cage that encapsulates xenon. In this work we use the prototypical biotinylated xenon biosensor to determine the relationship between the molecular composition of the xenon biosensor and the characteristics of protein-bound resonances. The effects of diastereomer overlap, dipole-dipole coupling, chemical shift anisotropy, xenon exchange, and biosensor conformational exchange on protein-bound biosensor signal were assessed. It was found that optimal protein-bound biosensor signal can be obtained by minimizing the number of biosensor diastereomers and using a flexible linker of appropriate length. Both the linewidth and sensitivity of chemical shift to protein binding of the xenon biosensor were found to be inversely proportional to linker length.

We study the problem of instanton generated superpotentials in Calabi-Yau orientifold compactifications directly in type IIB string theory. To this end, we derive the Dirac equation on a Euclidean D3 brane in the presence of background fluxes. We propose an index which governs whether the generation of a superpotential in the effective 4d theory by D3 brane instantons is possible. Applying the formalism to various classes of examples, including the K3 x T{sup 2}/Z{sub 2} orientifold, in the absence and presence of fluxes, we show that our results are consistent with conclusions attainable via duality from an M-theory analysis.

Characterizing percolation patterns in unsaturated fractured rock has posed a greater challenge to modeling investigations than comparable saturated zone studies, because of the heterogeneous nature of unsaturated media and the great number of variables impacting unsaturated flow. This paper presents an integrated modeling methodology for quantitatively characterizing percolation patterns in the unsaturated zone of Yucca Mountain, Nevada, a proposed underground repository site for storing high-level radioactive waste. The modeling approach integrates a wide variety of moisture, pneumatic, thermal, and isotopic geochemical field data into a comprehensive three-dimensional numerical model for modeling analyses. It takes into account the coupled processes of fluid and heat flow and chemical isotopic transport in Yucca Mountain's highly heterogeneous, unsaturated fractured tuffs. Modeling results are examined against different types of field-measured data and then used to evaluate different hydrogeological conceptualizations and their results of flow patterns in the unsaturated zone. In particular, this model provides a much clearer understanding of percolation patterns and flow behavior through the unsaturated zone, both crucial issues in assessing repository performance. The integrated approach for quantifying Yucca Mountain's flow system is demonstrated to provide a practical modeling tool for characterizing flow and transport processes in complex subsurface systems.