Many previous studies have demonstrated that gold compounds possess successful results in catalysis and in medicinal chemistry. The central aim of this dissertation is the design and synthesis of novel gold (I) acyclic diamino carbene complexes as a chemotherapeutic agent for triple-negative breast cancer (TNBC) and for catalysis. In this study, a series of chiral neutral and cationic gold (I) acyclic diamino carbene (ADC) complexes and neutral gold (I) bis- ADC complexes have been synthesized. As the chiral neutral gold (I) ADCs, four diastereomers of S binaphthyl L proline tertiary butyl ester gold (I) chloride, S binaphthyl D proline tertiary butyl ester gold (I) chloride, R binaphthyl L proline tertiary butyl ester gold (I) chloride, and R binaphthyl D proline tertiary butyl ester gold (I) chloride have been synthesized and characterized. Different chiral gold (I) ADC complexes with bulky chiral binaphthyl group and with different amine groups of morpholine, chiral proline methyl ester, and benzyl ester have been synthesized and characterized. After that four diastereomers of the nitrile adduct of cationic binaphthyl proline tertiary butyl ester nitrile and four diastereomers of the isonitrile versions of it have been synthesized and characterized. A series of gold (I) cationic bis ADC complexes …

Here, we show that training with multiple noncommunicable diseases (NCDs) is both feasible and beneficial to modeling this class of diseases. We first use data from the Cancer Genome Atlas (TCGA) to train a pan cancer model, and then characterize the information the model has learned about the cancers. In doing this we show that the model has learned concepts that are relevant to the task of cancer classification. We also test the model on datasets derived independently of the TCGA cohort and show that the model is robust to data outside of its training distribution such as precancerous legions and metastatic samples. We then utilize the cancer model as the basis of a transfer learning study where we retrain it on other, non-cancer NCDs. In doing so we show that NCDs with very differing underlying biology contain extractible information relevant to each other allowing for a broader model of NCDs to be developed with existing datasets. We then test the importance of the samples source tissue in the model and find that the NCD class and tissue source may not be independent in our model. To address this, we use the tissue encodings to create augmented samples. We test …

PCBs are synthetic organic compounds known for their toxicity to many organisms and are notorious for having large discrepancies between measured and nominal concentrations. Historically thought to be less toxic, non-dioxin-like (NDL) PCBs represent the majority of congeners and are capable of eliciting neurotoxic effects. NDL-PCBs remain understudied, including their effects on aquatic organisms. In the first study, I collected extensive chemistry data and data on neurobehavioral and cardiac endpoints to test the acute effects of exposure to an NDL-PCB mixture on early life stage zebrafish. Neurobehavioral effects observed in the first study indicated a potential for longer term behavioral effects in these fish. In the second study, I collected data on feeding, social, and memory behavior of zebrafish at time points beyond the acute exposure from the first study. Acute and longer-term behavioral endpoints in the first and second studies demonstrated effects from PCB exposure but did not indicate mechanisms. In the third study, I collected untargeted and targeted metabolomic data on amino acid, sugar, anionic compound, and neurotransmitter profiles to determine the specific pathways affected by exposure to an NDL-PCB mixture. These combined data from these studies provide a unique insight into the chemical profile of an NDL-PCB …

The relationship between Erasmus of Rotterdam and the religious movement called the Devotio Moderna, especially the latter's relevance to Erasmian piety, has been a somewhat contentious historiographical issue. This thesis examines that relationship, and asserts that the Devotio Moderna was a crucial formative aspect of Erasmus' religiosity. However, its relevance ought not be overstated, due to the humanist's significant developments away from his spiritual forerunners.

As rates of autism diagnosis continue to rise, more autistic students are graduating high school, and seeking to pursue postsecondary education options. Dual credit coursework has proven to be advantageous for college enrollment, success, and completion rates. Autistic students, however, are not equally represented in these college-level courses. The purpose of this qualitative study was to review dual credit recruitment practices and experiences, as told from the perspective of autistic students who completed one or more dual credit courses. Relying on student voice and a disability studies perspective, the intent of this study was to inform school leaders on how to facilitate the recruitment and participation of autistic students in dual credit courses, reducing the impact of institutional ableism. Traditional informational sessions proved ineffective as a recruitment tool. While parents influenced students' decisions to enroll in dual credit classes, parents' previous college experience factored into how much support students received. Teachers had the most meaningful influence due to their personal relationships with the students. Students with early-identified advanced academic ability received more encouragement to enroll, suggesting staff training and recruitment intentionality are key components for increasing autistic students' enrollment in dual credit programs. The intense bullying that students experienced in …

This study explored how well specific socio-cognitive processes (i.e., interpersonal problems, empathy, hostile attributional biases, envy/jealousy) predicted the manifestations of both grandiose and vulnerable narcissism. Additionally, we explored the impact of both forms of narcissism on the presence of maladaptive social behaviors (i.e., the perpetration of psychological abuse). We found that domineering interpersonal behaviors and a propensity to fantasize predicted significant unique variance in grandiose narcissism; envy of others, hostile attributional biases, and a propensity to fantasize predicted significant unique variance in vulnerable narcissism. Additionally, while domineering interpersonal behaviors and hostile attributional biases predicted significant variance in psychological abuse perpetration, only vulnerable narcissism added significant unique variance to its regression model. Lastly, only domineering interpersonal behaviors, envy of others, and hostile attributional biases predicted significant unique variance in psychological abuse victimization; narcissism was nonsignificant. The results of our study will contribute to an increased understanding of the nature of both grandiose and vulnerable narcissism and the impacts these personality styles have on an individual's ability to function effectively in interpersonal relationships.

Tabletop role-playing games (TRPGs) present a unique opportunity to study political behavior. In educational settings, role-playing games (RPGs) of all kinds have proven to be valuable educational tools, and even when played for fun, participating in role playing games has been shown to increase one's level of confidence. Knowing this, I designed an experiment to attempt to increase internal political efficacy through the use of a politically-themed TRPG. I took inspiration from the original TRPGs of the 1970s and 1980s which were used purely for entertainment purposes to create my own game in a traditional TRPG setting with current issues woven into the story of the game (also called a campaign), and utilized quantitative and qualitative methods to analyze participants' reactions to the campaign and levels of efficacy. In doing so, I seek to determine whether players will recognize real-world issues when presented in a science fiction or fantasy-themed campaign. Furthermore, given that TRPGs have the potential to shape players' understanding of how the world works and their place in it, will players be more motivated to act on said issues presented in-game, even if they do not consciously make the connection between the real-life issues presented in the science …

Considering that both cardiovascular disease (CVD) and congenital heart diseases (CHD) are still the leading cause of morbidity and mortality worldwide, there is a need for a robust and reliable cardiac model. Cardiac organoids are complex, three-dimensional cellular constructs that recapitulate the processes of the human embryonic heart. However, certain vital morphological features within the fetus are not yet replicable with cardiac organoids. Here we report our investigation to generate cardiac organoids with chamber formations. Our method involves modulating the Wnt pathway at two different instances while also implementing two cell seeding densities, all to determine the most optimized that to produce chamber formations within cardiac organoids.

It is generally accepted among scholars that increases in descriptive representation result in increases in substantive representation. Although women's descriptive representation has increased in recent years, women are still underrepresented in politics. One reason for women's underrepresentation is that female candidates must overcome additional barriers in order to get elected, including on the low number of women in the pipeline to elected office, party gatekeeping, women's lower levels of political ambition, and voters' negative gender stereotypes about female candidates. Changes in women's descriptive representation and recent salience of women-friendly policies, such as abortion and paid maternity leave, has caused me to investigate whether implementation of these women-friendly policies result in an increase in women's descriptive representation. I assert that women-friendly policies reduce the barriers women must overcome to get elected to office. Specifically, the presence of more women-friendly abortion and paid maternity leave policies will result in an increase in women's descriptive representation at the state level. I find partial support for a relationship between these women-friendly policies and higher levels of women's descriptive representation. State-level abortion protections are associated with higher levels of women's descriptive representation in the state legislature.

Audit inquiry can be a valuable source of information for auditors, particularly when the client provides useful information about important issues that could affect the audit. Recent studies indicate that the way an audit inquiry is conducted can affect the level of cooperation in the client's response. In this study, I investigate the use of social norms as an intervention auditors could include in their inquiries to increase the likelihood of client cooperation. To test my hypotheses, I conducted a 2x2 between-subjects experiment with 138 MBA and senior accounting students who proxied for non-accounting and accounting managers, respectively. I manipulated the auditor's use of a positive descriptive norm, which informed participants that the desired behavior is typical among similar others. I also manipulated the auditor's use of a negative injunctive norm, which informed participants of social disapproval for not engaging in the desired behavior. The dependent variable was a scaled measure of the likelihood the participant would disclose useful information in their response to the auditor. I find evidence of a main effect for both social norms I test. I do not find evidence of an interaction between the two social norms. My findings contribute to the audit literature as …

The purpose of this dissertation was to understand and compare the effect of training non-native English Speaking (NNES) learners (N = 480) in two distinct learning environments, (i) traditional face-to-face and (ii) online synchronous hybrid learning (SHL). In the traditional training mode, NNES learners (n = 360) were trained by NNES voice and accent (VANC) trainers in a physical, face-to-face setting. In the second, CAPT+SHL training mode, the NNES learners were trained by NNES VANC trainers with the help of a native-English computer-assisted pronunciation training (CAPT) tool in an online SHL environment. Factor analysis, higher-order factor analysis, hierarchical cluster analysis, and multidimensional scaling yielded a reliable scale, Eddie's Voice Test (EVT). Multiple regression yielded a predictive model between NNES pronunciation and their performance. In addition, the CAPT+SHL training mode produced higher scores on pronunciation and performance than the traditional training mode, suggesting a combination of NES and NNES VANC instructors are more effective in training NNES learners than NNES instructors by themselves. The case study (n = 3) on VANC trainers' perception of CAPT and SHL yielded three themes: (1) challenges with synchronous hybrid learning (sub-themes include physical challenges, social challenges, and cognitive challenges); (2) computer-assisted pronunciation training (CAPT) impact …

The concept of "creativity" has been studied under the perspective of variability in behavior analysis. Creativity and variable responding contributes to problem solving in novel situations, learning new responses in different environments, and promote interactions that would otherwise be prohibited by repetitive behaviors and routines. During childhood, play contributes to the emergence of creativity and variability. Children develop many skills that are important to their lives while engaging in play behaviors. Some of those skills include self-advocacy, communication, and problem solving. Researchers have investigated different methods to promote variable play skills in children with autism spectrum disorder (ASD). There is limited research on prompting as an isolated variable in increasing variability in play responses. The purpose of this study was to investigate the effects of prompting on variable play skills. Results indicated that verbal instructions and modeling were effective in increasing variable play responses. Both participants displayed a sustained increase in novel item engagement when exposed to prompting.

Despite the evidence that supports the benefits of a holistic, collaborative approach to autism intervention, but there is little training to teach those skills to professionals. Behavior analysts working in applied settings will often partner with different individuals from very different backgrounds and disciplines. Skilled Dialogue has been recommended as an approach to conversations that values everyone's contributions in fostering compassionate, collaborative, and culturally responsive care to benefit the children served. The purpose of this study was to evaluate the effects of a training workshop to teach the concept and strategies of skilled dialogue to behavior analysts in training. The participants were taught and practiced using the six strategies of Skilled Dialogue: welcoming, allowing, sense-making, appreciating, joining, and harmonizing through use of instructions, rationales, activities, simulations, and feedback. The success of the training was evaluated using a multiple baseline design across training components. Audio and video responses to role-play scenarios were recorded, transcribed, and scored to measure the results of the training workshop on communication skills. The results suggested that the training workshop was an effective method to teaching future behavior analysts how to engage in the strategies and components of skilled dialogue, increasingly the likelihood of collaborative, and children …

Metallic Glasses are multi-component alloys with disordered atomic structures and unique and attractive properties such as ultra-high strength, soft magnetism, and excellent corrosion/wear resistance. In addition, they may be thermoplastically processed in the supercooled liquid region to desired shapes across multiple length-scales. Recently developed metallic glasses based on noble metals (such as Pt and Pd) are highly active in catalytic reactions such as hydrogen oxidation, oxygen reduction, and degradation of organic chemicals for environmental remediation. However, there is a limited understanding of the underlying electrochemical mechanisms and surface characteristics of catalytically active metallic glasses. Here, we demonstrate the influence of alloy chemistry and the associated electronic structure on the activity of a systematic series of Pt42.5−xPdxCu27Ni9.5P21 bulk metallic glasses (BMGs) with x = 0 to 42.5 at%. The activity and electrochemically active surface area as a function of composition are in the form of volcano plots, with a peak around an equal proportion of Pt and Pd. These amorphous alloys showed more than two times the hydrogen oxidation reactivity compared to pure Pt. This high activity was attributed to their lower electron work function and higher binding energy of Pt core level that reduced charge-transfer resistance and improved electrocatalytic activity …

This MFA graduate thesis explores the intersection of therapeutic photography, generational trauma, and Christian spirituality in promoting spiritual healing in disabled veterans diagnosed with post-traumatic stress disorder (PTSD). Drawing from personal experience, rigorous biblical training, and extensive research, I argue that incorporating faith-based practices and beliefs can complement existing PTSD support and enhance spiritual and mental well-being. Through the lens of generational trauma, the thesis analyzes the complex interplay between individual and collective trauma. It posits that the healing process is intrinsically linked to the restoration of the individual and community. I present a framework for therapeutic photography that incorporates Christian spiritual principles and offers practical guidelines for implementation in conjunction with therapeutic photography. The thesis concludes with a call to action for faith-based communities, mental health practitioners, and policymakers to recognize and address the spiritual and artistic therapeutic needs of disabled veterans with PTSD.

The blood-brain barrier (BBB) is composed of brain microvascular endothelial cells (BMECs), pericytes, and astrocytic endfeet, which regulate the transport of molecules into and out of the brain. BMECs possess intrinsic barrier properties that limit the passage of approximately 98% of small molecules into the brain in healthy individuals. However, in some brain diseases, the BBB undergoes structural and functional alterations, which can contribute to disease progression. In this study, we aimed to investigate the BBB by exploring the effects of endothelial cell stretching and the optimal dimensionality of stretching to enhance endothelium barrier tightness in Chapter 2. Subsequently, we developed an endothelium gradient stretching device to further examine the stretching effect in Chapter 3. Additionally, we investigated the promotion of endothelium tightness through the use of electrospun fibers, wherein we controlled the pore size. Based on these findings, we designed and fabricated an organ chip model that incorporates mechanical stretching, microfluidic techniques, electrospun fibers, and hydrogel extracellular matrix (ECM). The results of permeability testing demonstrated that this chip significantly improved the tightness of microvascular selective transport ability and has the potential to be used in drug sorting for central nervous system (CNS) diseases.

Corporate environmental social and governance (ESG) reporting is becoming subject to increased scrutiny by regulators, investors and public. This dissertation will contribute to several research streams in the extant literature. This dissertation is the first to show the impact of employee environmental values and attitudes on reporting and whistleblowing decisions, making contributions to accounting, management, whistleblowing and environmental psychology literatures. Next, it is among the first to examine the role of the identity of ESG assurance provider in ESG reporting context. Further, it is among the first to examine the impact of SEC assurance mandate and the value of assurance over ESG information, thus contributing to audit literature. Using experimental methodology, I examine how ESG report assurance, ESG report assurance provider, ESG issue type, and environmentalism as a personality factor influence employee decisions to accede to a supervisory request to misrepresent ESG information, to report management's actions to a corporate hotline, to post information about management wrongdoing on social media, to switch jobs, and to judge ESG misreporting actions as unethical. The results indicate that (1) employee personality factor environmentalism impacts their ESG reporting decisions; (2) pro-environmental employees are more likely to whistleblow when assurance is not mandated, and they …

The Examination for Professional Practice in Psychology (EPPP) is a requirement for licensure as a psychologist across the entire United States as well as in numerous territories and provinces. Despite many longstanding criticisms and findings of bias, the EPPP is being expanded (adding a second, putatively competency-based, portion to the overall exam) and rebranded as the Enhanced EPPP. A review of literature reveals strong skepticism surrounding these developments, particularly with respect to the issue of criterion validity. The current study sought to examine the criterion validity of the EPPP by (1) drawing archival competency assessment data from existing measures (convergent validity) and (2) gathering new neurocognitive and emotional intelligence data, along with demographic data (discriminant validity), with copies of EPPP score reports from individuals who have recently taken the EPPP. Competency ratings did not significantly positively correlate with EPPP scores and, instead, indicated the opposite trend. Analyses also revealed a significant relationship between ethnicity and exam scores, with White individuals scoring higher than other ethnicities. Finally, performance on neurocognitive tests significantly positively correlated with exam scores, indicating that general test taking abilities play a larger role than abilities and competencies unique to the psychology field. Given the gatekeeping role the …

Extant research suggests communication styles (CS) such as constructive communication (CC) to be associated positively with relationship satisfaction (RS) and negatively with mental health (MH) whereas self-demand / partner withdraw (SD/PW) communication is associated negatively with RS and positively with MH. Research also suggests child abuse (CA) to be associated with poorer CS, lower RS, and poorer MH. Further, RS has been differentially associated with MH and CS in adult intimate relationships. However, no study has examined these associations simultaneously. The current study aimed to (1) assess these associations in IPV-exposed women and (2) assess differences between those with and without a history of CA. Data (n = 412; Mage = 36.77, SD = 12.54) come from a larger data collection project (N = 676). I hypothesized that: (1) higher CC and RS would be associated with lower severity of MH symptoms; (2) higher SD/PW and lower RS would be associated with higher severity of MH symptoms; (3) women with a history of CA will report less CC, lower RS, and higher severity of MH symptoms; and (4) women with a history of CA will report more SD/PW, lower RS, and higher severity of MH symptoms. Results did not support …

The traditional definition of tourism has been transformed by significant advancements in communication and information technology. The concept of Metaverse, derived from the words "meta" (meaning beyond) and "verse" (meaning universe), has redefined how people experience travel. This innovative concept combines virtual reality, augmented reality, and artificial intelligence to create virtually augmented spaces. However, the tourism industry should clarify and narrow down the definition of Metaverse and its intriguing concept for its successful adoption in the future. Thus, it is crucial to define Metaverse tourism and understand how users will accept it in the near future. This study aims to comprehend the technology behind Metaverse tourism, review current research on the topic, and identify the critical factors related to experiential Metaverse tourism. The paper also examines how computer self-efficacy, novelty seeking, subjective norm, job relevance, perceived usefulness, perceived ease of use, and perceived enjoyment can influence expected user satisfaction and behavioral intention, given the context of situational motivation. The findings have significant implications for theory and management, addressing various questions related to users' perceptions, expectations, design considerations, stakeholder preparations, and performance assessment of metaverse technology in tourism applications.

This research aims to examine current practices in gifted and talented educator professional learning, as well as teacher attitudes, beliefs, and experiences towards gifted education in order to explore opportunities to further develop and improve professional learning structures. Through a qualitative methodology following the constructivist-interpretivist paradigm, this research utilizes a phenomenological interview design in which data from educator interviews are examined through thematic analysis. To support and further extrapolate on the feedback from the interviews, this research also includes a document analysis of the published descriptions of 30-hour educator training required for those providing GT services in the state of Texas. The thematic analysis of interviews identified three major themes and two minor themes after engaging in a deep analysis of the interview transcriptions. These major themes are the (1) utility of professional learning, (2) shared control of learning, and (3) understanding the whole student. Minor themes are (i) long-term career growth and (ii) role of professional support networks and connections. Results of the document analysis illustrate that the most frequent descriptions are associated with the abilities participants will take from the learning. Within this descriptive code, most of the language focused on learner competence, while few of the descriptions …

Demand for the skill of critical thinking is extensive in both higher education and in the workforce. The purpose of the current research is to examine the relationship between critical thinking educational efforts (e.g., programs incorporating high impact practices) and higher education student outcomes. For this study, student outcomes were defined as cumulative grade point average and student program retention. The study used existing data which were obtained from a large public research university in the southwest United States. The study found that higher critical thinking was significantly associated with higher overall GPA, and this relationship was stronger in males as compared to females. However, students' critical thinking was not significantly related to program retention. Findings from this study appear to confirm previous studies indicating a positive relationship between students' ability to think critically and GPA. The study also suggests that elements promoting critical thinking can be successfully embedded into undergraduate curricula through various means, including the use of high impact practices.

This study aimed to broaden the understanding of young South Asian women's experiences/relationships and participation in leisure physical activities at universities in the United States. Using a phenomenological design, semi-structured interviews of 20-30 minutes duration were conducted with 5 South Asian women about their relationships and experiences when participating or attempting to participate in physical activity while attending university in the US. The following criteria were set for participants to be included in this study: they should be between the ages of 18 and 24, non-US citizens from a South Asian country, attend a university in the US, and engage in other physical activities. The interviews were audio recorded via Zoom and then the audio data were transcribed verbatim and then coded to identify the major barriers commonly experienced by participants. Results indicated that many girls and women perceived the US as a "safer" place with excellent infrastructure, ample opportunities to engage in physical activities, and convenient access to gyms, which encourage them (women) to remain active. Most participants were hesitant to participate in physical activities because of the culturally non-responsiveness of the system. This research study was done in a shorter time span with a small sample size. Further …

Principal workloads and demands are steadily increasing while principal health and well-being are declining, resulting in increased rates of principal turnover. Currently, principals are experiencing numerous work-related stressors that are increasing burnout. In many cases, school leaders are sacrificing their families and health to lead their schools. As school success is linked with principal leadership, principal burnout and wellness demands further discussion and investigation. Yet, there is a limited body of research that examines the lived experiences of principals who experience burnout. Consequently, this researcher conducted a phenomenological qualitative study of 12 Texas K-12 elementary and secondary public school principals in central Texas. Findings pointed out that principals experience burnout in waves. While the COVID-19 pandemic greatly impacted the burnout principal experienced, political divisiveness and social media attacks intensified their burnout. Additional findings revealed that burnout can cause principals to question staying in their role and negatively affect the quality of their family relationships as well as their health. Principals coped with their burnout by being aware of their emotions, spending time doing things that brought happiness, exercising, and reverting back to their faith in God. Additionally, principals believed that having knowledgeable district leaders who are visible, trust their leadership, …