Research progress in the following areas is reported. The phagocytosis activity and induction of cell transformation by a number of particulate metal compounds in tissue culture systems (crystalline or amorphous NiS, CoS, CuS, and CdS) have been examined. The induction of DNA strand breaks by various water soluble and insoluble metal compounds was demonstrated. It has been found that the surface charge of a particle has a direct influence on whether it will be phagocytosed and this property ultimately affects its carcinogenic ability. The ability of nickel compounds to interact and bind with DNA, RNA and protein was investigated. (ACR)

As part of the Milliwatt Generator (MWG) Program, a second series of pressure burst capsules welded offsite was tested; the resulting data indicate that the welds are very similar to those in the first series of capsules. Sufficient hardware was fabricated to meet all scheduled commitments. To provide a unit for feasibility testing, a heat source clad with Hastelloy C was reclad with Inconel 600. Forming development tests on Inconel 600 were conducted with favorable results. A QAS-3 survey was conducted and a satisfactory rating was received. Lot 11 qualification began on T-111 materials. The production period ended with an overall process yield of 99.6%, and a dollar percent defective rate of 0.60%.