Weekly newspaper from Timpson, Texas that includes local, state, and national news along with advertising.

A proof-of-principle electron electric dipole moment (e-EDM)experiment using slow cesium atoms, nulled magnetic fields, and electricfield quantization has been performed. With the ambient magnetic fieldsseen by the atoms reduced to less than 200 pT, an electric field of 6MV/m lifts the degeneracy between states of unequal lbar mF rbar and,along with the low (approximately 3 m/s) velocity, suppresses thesystematic effect from the motional magnetic field. The low velocity andsmall residual magnetic field have made it possible to induce transitionsbetween states and to perform state preparation, analysis, and detectionin regions free of applied static magnetic and electric fields. Thisexperiment demonstrates techniques that may be used to improve the e-EDMlimit by two orders of magnitude, but it is not in itself a sensitivee-EDM search, mostly due to limitations of the laser system.

Daily newspaper from Perry, Oklahoma that includes local, state, and national news along with advertising.

Weekly newspaper from Canadian, Texas that includes local, state and national news along with some advertising.

Daily newspaper from Chickasha, Oklahoma that includes local, state, and national news along with advertising.

Daily newspaper from Altus, Oklahoma that includes local, state, and national news along with advertising.

Many experimental approaches in biology and biophysics, as well as applications in diagnosis and drug discovery, require proteins to be immobilized on solid supports. Protein microarrays, for example, provide a high-throughput format to study biomolecular interactions. The technique employed for protein immobilization is a key to the success of these applications. Recent biochemical developments are allowing, for the first time, the selective and traceless immobilization of proteins generated by cell-free systems without the need for purification and/or reconcentration prior to the immobilization step.

The cyclotide MCoTI-II is a powerful trypsin inhibitor recently isolated from the seeds of Momordica cochinchinensis, a plant member of cucurbitaceae family. We report for the first time the in vivo biosynthesis of natively-folded MCoTI-II inside live E. coli cells. Our biomimetic approach involves the intracellular backbone cyclization of a linear cyclotide-intein fusion precursor mediated by a modified protein splicing domain. The cyclized peptide then spontaneously folds into its native conformation. The use of genetically engineered E. coli cells containing mutations in the glutathione and thioredoxin reductase genes considerably improves the production of folded MCoTI-II in vivo. Biochemical and structural characterization of the recombinant MCoTI-II confirmed its identity. Biosynthetic access to correctly-folded cyclotides allows the possibility of generating cell-based combinatorial libraries that can be screened inside living cells for their ability to modulate or inhibit cellular processes.

Daily newspaper from Baytown, Texas that includes local, state, and national news along with advertising.

This report analyzes Division C of the Department of Defense Emergency Supplemental Appropriations, P.L. 109-148, which was signed into law on December 30, 2005, and which limits liability with respect to pandemic flu and other public health countermeasures.

Biodetection instrumentation that is capable of functioning effectively outside the controlled laboratory environment is critical for the detection of health threats, and is a crucial technology for Health Security. Experience in bringing technologies from the basic research laboratory to integrated fieldable instruments suggests lessons for the engineering of these systems. This overview will cover several classes of such devices, with examples from systems developed for homeland security missions by Lawrence Livermore National Laboratory (LLNL). Recent trends suggest that front-end sample processing is becoming a critical performance-determining factor for many classes of fieldable biodetection devices. This paper introduces some results of a recent study that was undertaken to assess the requirements and potential technologies for next-generation integrated sample processing.

We report the ongoing work of our group in hydrodynamics and radiation hydrodynamics with astrophysical applications. During the period of the existing grant, we have carried out two types of experiments at the Omega laser. One set of experiments has studied radiatively collapsing shocks, obtaining data using a backlit pinhole with a 100 ps backlighter and beginning to develop the ability to look into the shock tube with optical or x-ray diagnostics. Other experiments have studied the deeply nonlinear development of the Rayleigh-Taylor (RT) instability from complex initial conditions, using dual-axis radiographic data with backlit pinholes and ungated detectors to complete the data set for a Ph.D. student. We lead a team that is developing a proposal for experiments at the National Ignition Facility and are involved in experiments at NIKE and LIL. All these experiments have applications to astrophysics, discussed in the corresponding papers. We assemble the targets for the experiments at Michigan, where we also prepare many of the simple components. We also have several projects underway in our laboratory involving our x-ray source. The above activities, in addition to a variety of data analysis and design projects, provide good experience for graduate and undergraduates students. In the …

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Weekly newspaper from Lexington, Oklahoma that includes local, state, and national news along with advertising.

Weekly newspaper from Sachse, Texas that includes local, state and national news along with advertising.

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Weekly newspaper from Garber, Oklahoma that includes local, state, and national news along with advertising.

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Weekly newspaper from Port Aransas, Texas on Mustang Island that includes local, state and national news along with extensive advertising.

Since the last report, there have been no material changes in the detector element inventories in buildings 151 and 332 at LLNL. Stable element inventories in building 151 have remained stable since the inventory in September 2005. For the first time in many years, Stockpile Radiochemistry personnel viewed radioactive tracer materials that reside in building 332. A list of LLNL tracers and locations are available under separate cover. Despite the recent NNSA agreement to retain 2.8 kg of {sup 233}U for programmatic purposes, we have yet to identify a location that is appropriate and will accept the material. A recent visit to the Oak Ridge National Laboratory (ORNL) in September 2006 revealed nearly 190 kg of material with very high {sup 233}U content scheduled for down-blending in various chemical and isotopic forms. The chemical form, isotopic and chemical purities of this material were such that roughly 150 kg of the material was of comparable composition to the desired tracer package material and would be acceptable for use in an underground test, should the US even conduct such a test. Efforts continue to remove 2.8 kg of material from the down-blend cue and reserve it for the Test Readiness mission.

Weekly newspaper from De Leon, Texas that includes local, state, and national news along with advertising.

The Global Nuclear Energy Partnership (GNEP), recently announced by DOE Secretary Bodman, poses significant new challenges with regard to securing, safeguarding, monitoring and tracking nuclear materials. In order to reduce the risk of nuclear proliferation, new technologies must be developed to reduce the risk that nuclear material can be diverted from its intended use. Regardless of the specific nature of the fuel cycle, nuclear forensics and attribution will play key roles to ensure the effectiveness of nonproliferation controls and to deter the likelihood of illicit activities. As the leader of the DHS nuclear and radiological pre-detonation attribution program, LLNL is uniquely positioned to play a national leadership role in this effort. Ensuring that individuals or organizations engaged in illicit trafficking are rapidly identified and apprehended following theft or diversion of nuclear material provides a strong deterrent against unlawful activities. Key to establishing this deterrent is developing the ability to rapidly and accurately determine the identity, source and prior use history of any interdicted nuclear material. Taggants offer one potentially effective means for positively identifying lost or stolen nuclear fuels. Taggants are materials that can be encoded with a unique signature and introduced into nuclear fuel during fuel fabrication. During a …

Weekly newspaper from Archer City, Texas that includes local, state, and national news along with advertising.

Weekly newspaper from Albany, Texas that includes local, county, and state news along with extensive advertising.