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8-oxoguainine enhances bending of DNA that favors binding of glycosylases
Molecular dynamics (MD) simulations were carried out on the DNA oligonucleotide GGGAACAACTAG:CTAGTTGTTCCC in its native form and with guanine in the central G19:C6 base pair replaced by 8-oxoguanine (8oxoG). A box of explicit water molecules was used for solvation and Na+ counterions were added to neutralize the system. The direction and magnitude of global bending were assessed by a technique used previously to analyze simulations of DNA containing a thymine dimer. The presence of 8oxoG did not greatly affect the magnitude of DNA bending; however, bending into the major groove was significantly more probable when 8oxoG replaced G19. Crystal structures of glycosylases bound to damaged-DNA substrates consistently show a sharp bend into the major groove at the damage site. We conclude that changes in bending dynamics that assist the formation of this kink are a part of the mechanism by which glycosylases of the base excision repair pathway recognize the presence of 8oxoG in DNA.
Date:
April 23, 2003
Creator:
Miller, John H.
Object Type:
Article
System:
The UNT Digital Library
15th Street News (Midwest City, Okla.), Vol. 33, No. [25], Ed. 1 Friday, April 23, 2004
Newspaper from Rose State College in Midwest City, Oklahoma that includes national, local, and campus news along with advertising.
Date:
April 23, 2004
Creator:
Rollman, Jon
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
3D Magnetotelluic characterization of the Coso GeothermalField
Electrical resistivity may contribute to progress inunderstanding geothermal systems by imaging the geometry, bounds andcontrolling structures in existing production, and thereby perhapssuggesting new areas for field expansion. To these ends, a dense grid ofmagnetotelluric (MT) stations plus a single line of contiguous bipolearray profiling has been acquired over the east flank of the Cosogeothermal system. Acquiring good quality MT data in producing geothermalsystems is a challenge due to production related electromagnetic (EM)noise and, in the case of Coso, due to proximity of a regional DCintertie power transmission line. To achieve good results, a remotereference completely outside the influence of the dominant source of EMnoise must be established. Experimental results so far indicate thatemplacing a reference site in Amargosa Valley, NV, 65 miles from the DCintertie, isstill insufficient for noise cancellation much of the time.Even though the DC line EM fields are planar at this distance, theyremain coherent with the nonplanar fields in the Coso area hence remotereferencing produces incorrect responses. We have successfully unwrappedand applied MT times series from the permanent observatory at Parkfield,CA, and these appear adequate to suppress the interference of thecultural EM noise. The efficacy of this observatory is confirmed bycomparison to stations taken using an ultra-distant …
Date:
April 23, 2007
Creator:
Newman, Gregory A.; Hoversten, G. Michael; Wannamaker, Philip E. & Gasperikova, Erika
Object Type:
Article
System:
The UNT Digital Library
80th Texas Legislature, Regular Session, House Bill 674, Chapter 8
Bill introduced by the Texas House of Representatives relating to the authority of the Department of Information Resources to accept gifts and grants.
Date:
April 23, 2007
Creator:
Texas. Legislature. House of Representatives.
Object Type:
Legislative Document
System:
The Portal to Texas History
80th Texas Legislature, Regular Session, House Bill 675, Chapter 9
Bill introduced by the Texas House of Representatives relating to the membership of the governing board of the Department of Information Resources.
Date:
April 23, 2007
Creator:
Texas. Legislature. House of Representatives.
Object Type:
Legislative Document
System:
The Portal to Texas History
80th Texas Legislature, Regular Session, Senate Bill 135, Chapter 10
Bill introduced by the Texas Senate relating to the ability of public school employees to communicate with members of a school district board of trustees.
Date:
April 23, 2007
Creator:
Texas. Legislature. Senate.
Object Type:
Legislative Document
System:
The Portal to Texas History
80th Texas Legislature, Regular Session, Senate Bill 300, Chapter 11
Bill introduced by the Texas Senate relating to the duration of judgment liens in favor of the state.
Date:
April 23, 2007
Creator:
Texas. Legislature. Senate.
Object Type:
Legislative Document
System:
The Portal to Texas History
80th Texas Legislature, Regular Session, Senate Bill 330, Chapter 12
Bill introduced by the Texas Senate relating to enforcement of certain vehicle weight and safety requirements by a noncommissioned employee of the Department of Public Safety of the State of Texas.
Date:
April 23, 2007
Creator:
Texas. Legislature. Senate.
Object Type:
Legislative Document
System:
The Portal to Texas History
80th Texas Legislature, Regular Session, Senate Bill 332, Chapter 13
Bill introduced by the Texas Senate relating to the responsibility of an employer in relation to a person who drives a commercial motor vehicle; providing a criminal penalty.
Date:
April 23, 2007
Creator:
Texas. Legislature. Senate.
Object Type:
Legislative Document
System:
The Portal to Texas History
80th Texas Legislature, Regular Session, Senate Concurrent Resolution 53
Concurrent resolution introduced by the Texas Senate and House of Representatives proclaiming April 15 through 22, 2007, Days of Remembrance in memory of the victims of the Holocaust.
Date:
April 23, 2007
Creator:
Texas. Legislature. Senate.
Object Type:
Legislative Document
System:
The Portal to Texas History
81st Texas Legislature, Regular Session, House Bill 873, Chapter 2
Bill introduced by the Texas House of Representatives relating to incentives for the film, television, video, and digital interactive media production industries.
Date:
April 23, 2009
Creator:
Texas. Legislature. House of Representatives.
Object Type:
Legislative Document
System:
The Portal to Texas History
Abstinence Education: Assessing the Accuracy and Effectiveness of Federally Funded Programs
Testimony issued by the Government Accountability Office with an abstract that begins "Among the efforts of the Department of Health and Human Services (HHS) to reduce the incidence of sexually transmitted diseases and unintended pregnancies, the agency provides funding to states and organizations that offer abstinence-until-marriage education. GAO was asked to testify on the oversight of federally funded abstinence-until-marriage education programs. This testimony is primarily based on Abstinence Education: Efforts to Assess the Accuracy and Effectiveness of Federally Funded Programs, GAO-07-87 (Oct. 3, 2006). In this testimony, GAO discusses efforts by (1) HHS and states to assess the scientific accuracy of materials used in abstinence-until-marriage education programs and (2) HHS, states, and researchers to assess the effectiveness of abstinence-until-marriage education programs. GAO also discusses a Public Health Service Act requirement regarding medically accurate information about condom effectiveness. GAO focused on the three main federally funded abstinence-until-marriage programs and reviewed documents and interviewed HHS officials in the Administration for Children and Families (ACF) and the Office of Population Affairs (OPA). To update certain information, GAO contacted officials from ACF and OPA."
Date:
April 23, 2008
Creator:
United States. Government Accountability Office.
Object Type:
Text
System:
The UNT Digital Library
Access to Government Information In the United States
The Constitution of the United States makes no specific allowance for any one of the co-equal branches to have access to information held by the others and contains no provision expressly establishing a procedure for, or a right of, public access to government information. Nonetheless, Congress has legislated various public access laws. These include two records access statutes — the Freedom of Information Act and the Privacy Act — and two meetings access statutes — the Federal Advisory Committee Act and the Government in the Sunshine Act. This report provides background on the issue of government transparency and examines relevant litigation.
Date:
April 23, 2007
Creator:
Relyea, Harold C. & Kolakowski, Michael W.
Object Type:
Report
System:
The UNT Digital Library
AIDS Funding for Federal Government Programs: FY1981-FY2009
This report provides an overview of Department of Health and Human Services (HHS) spending on HIV/AIDS (human immunodeficiency virus/acquired immune deficiency syndrome) as well as budget numbers for other federal government programs targeting HIV/AIDS.
Date:
April 23, 2008
Creator:
Johnson, Judith A.
Object Type:
Report
System:
The UNT Digital Library
Air to Blood Distribution of Volatile Organic Compounds: A Linear Free Energy Analysis
Article on air to blood distribution of volatile organic compounds and a linear free energy analysis.
Date:
April 23, 2005
Creator:
Abraham, M. H. (Michael H.); Ibrahim, Adam & Acree, William E. (William Eugene)
Object Type:
Article
System:
The UNT Digital Library
Airport Passenger Screening: Background and Issues for Congress
This report discusses challenges the Transportation Security Administration (TSA) will likely face to address projected growth in passenger airline travel while maintaining and improving upon the efficiency and effectiveness of passenger screening operations.
Date:
April 23, 2009
Creator:
Elias, Bart
Object Type:
Report
System:
The UNT Digital Library
The Albany News (Albany, Tex.), Vol. 133, No. 48, Ed. 1 Thursday, April 23, 2009
Weekly newspaper from Albany, Texas that includes local, county, and state news along with extensive advertising.
Date:
April 23, 2009
Creator:
Lucas, Melinda L.
Object Type:
Newspaper
System:
The Portal to Texas History
ALS control system IP I/O module upgrade
The Control System for the Advanced Light Source uses in-house designed IndustryPack (IP) I/O Modules in compact PCI (cPCI) chassis to control instrumentation. Each module consists of digital I/O ports and 16-bit analog I/O interfaced to instrumentation via a cPCI rear I/O card. During the past few years of installed operation, several factors have prompted investigation into the design of a new IP I/O Module. The ADC channels have significant offset drift over periods of days of initial installed operation. An in-situ calibration procedure was developed to address this problem, but it lacks speed and is inconvenient to perform. Digital I/O port limitations have led to increasing amounts of wasted I/O. Fast orbit feedback requires faster ADC sampling and better filtering than the current IP module offers. This paper discusses the issues related to the current IP I/O Module and the design of a new Double-size IP I/O Module.
Date:
April 23, 2004
Creator:
Weber, Jonah M. & Chin, Michael
Object Type:
Article
System:
The UNT Digital Library
Altus Times (Altus, Okla.), Vol. 101, No. 34, Ed. 1 Sunday, April 23, 2000
Daily newspaper from Altus, Oklahoma that includes local, state, and national news along with advertising.
Date:
April 23, 2000
Creator:
Bush, Michael
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
Altus Times (Altus, Okla.), Vol. 102, No. 34, Ed. 1 Monday, April 23, 2001
Daily newspaper from Altus, Oklahoma that includes local, state, and national news along with advertising.
Date:
April 23, 2001
Creator:
Bush, Michael
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
Altus Times (Altus, Okla.), Vol. 104, No. 33, Ed. 1 Tuesday, April 23, 2002
Daily newspaper from Altus, Oklahoma that includes local, state, and national news along with advertising.
Date:
April 23, 2002
Creator:
Bush, Michael
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
Altus Times (Altus, Okla.), Vol. 106, No. 20, Ed. 1 Friday, April 23, 2004
Daily newspaper from Altus, Oklahoma that includes local, state, and national news along with advertising.
Date:
April 23, 2004
Creator:
Andrews, Mike
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
Altus Times (Altus, Okla.), Vol. 107, No. 325, Ed. 1 Sunday, April 23, 2006
Daily newspaper from Altus, Oklahoma that includes local, state, and national news along with advertising.
Date:
April 23, 2006
Creator:
Bush, Michael
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
The Altus Times (Altus, Okla.), Vol. 108, No. 333, Ed. 1 Monday, April 23, 2007
Daily newspaper from Altus, Oklahoma that includes local, state, and national news along with advertising.
Date:
April 23, 2007
Creator:
Bush, Michael
Object Type:
Newspaper
System:
The Gateway to Oklahoma History