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Exceptional groups, symmetric spaces and applications (open access)

Exceptional groups, symmetric spaces and applications

In this article we provide a detailed description of a technique to obtain a simple parameterization for different exceptional Lie groups, such as G{sub 2}, F{sub 4} and E{sub 6}, based on their fibration structure. For the compact case, we construct a realization which is a generalization of the Euler angles for SU(2), while for the non compact version of G{sub 2(2)}/SO(4) we compute the Iwasawa decomposition. This allows us to obtain not only an explicit expression for the Haar measure on the group manifold, but also for the cosets G{sub 2}/SO(4), G{sub 2}/SU(3), F{sub 4}/Spin(9), E{sub 6}/F{sub 4} and G{sub 2(2)}/SO(4) that we used to find the concrete realization of the general element of the group. Moreover, as a by-product, in the simplest case of G{sub 2}/SO(4), we have been able to compute an Einstein metric and the vielbein. The relevance of these results in physics is discussed.
Date: March 31, 2009
Creator: Cerchiai, Bianca L. & Cacciatori, Sergio L.
Object Type: Book
System: The UNT Digital Library
The Express-Star (Chickasha, Okla.), Ed. 1 Tuesday, March 31, 2009 (open access)

The Express-Star (Chickasha, Okla.), Ed. 1 Tuesday, March 31, 2009

Daily newspaper from Chickasha, Oklahoma that includes local, state, and national news along with advertising.
Date: March 31, 2009
Creator: unknown
Object Type: Newspaper
System: The Gateway to Oklahoma History
Family Violence Prevention and Services Act: Programs and Funding (open access)

Family Violence Prevention and Services Act: Programs and Funding

This report describes programs authorized under the Family Violence Prevention and Services Act (FVPSA) and related initiatives, and provides authorization and appropriation levels. The FVPSA was originally enacted in 1984, as Title III of the Child Abuse Prevention and Treatment Act, to assist states in preventing incidents of family violence and to provide shelter and related assistance to victims of family violence and their dependents, with the expectation of preventing future acts of violence in families.
Date: March 31, 2009
Creator: Laney, Garrine P.
Object Type: Report
System: The UNT Digital Library
Federal Register, Volume 74, Number 60, March 31, 2009, Pages 14457-14702 (open access)

Federal Register, Volume 74, Number 60, March 31, 2009, Pages 14457-14702

Daily publication of the U.S. Office of the Federal Register contains rules and regulations, proposed legislation and rule changes, and other notices, including "Presidential proclamations and Executive Orders, Federal agency documents having general applicability and legal effect, documents required to be published by act of Congress, and other Federal agency documents of public interest" (p. ii). Table of Contents starts on page iii.
Date: March 31, 2009
Creator: United States. Office of the Federal Register.
Object Type: Journal/Magazine/Newsletter
System: The UNT Digital Library
Final Report for CRADA Agreement , AL-C-2006-01 with Microsens Biotechnologies: Detection of the Abnormal Prion Protein in Blood by Improving the Extraction of this Protein (open access)

Final Report for CRADA Agreement , AL-C-2006-01 with Microsens Biotechnologies: Detection of the Abnormal Prion Protein in Blood by Improving the Extraction of this Protein

Several conditions were examined to optimize the extraction protocol using Seprion beads for the abnormal prion protein. Different combinations of water, hexafluro-2-propanol and formic acid were used. The results of these extraction protocols showed that the magnetic beads coated with Seprion reagents were subject to degradation, themselves, when the extraction conditions that would solubilize the abnormal prion protein were used. These compounds caused interference in the immunoassay for the abnormal prion protein and rendered these protocols incompatible with the assay systems. In an attempt to overcome this problem, another approach was then used. The coated beads were used as an integral part of the assay platform. After washing away denaturing agents, the beads with the 'captured' abnormal prion were incubated directly in the immunoassay, followed by analysis by the capillary electrophoresis. When a capillary electrophoresis electro-kinetic separation was attempted, the beads disturbed the analysis making it impossible to interpret. A pressure separation method was then developed for capillary electrophoresis analysis. When 20 samples, 5 of which were positive were analyzed, the assay identified 4 of the 5 positives and had no false positives. When a larger number of samples were analyzed the results were not as good - there were …
Date: March 31, 2009
Creator: Schmerr, Mary Jo
Object Type: Report
System: The UNT Digital Library
Final Report for the NERI Project (open access)

Final Report for the NERI Project

This final report summarizes the research activities during the entire performance period of the NERI grant, including the extra 9 months granted under a no-cost time extension. Building up on the 14 quarterly reports submitted through October 2008, we present here an overview of the research accomplishments under the five tasks originally proposed in July 2004, together with citations for publications resulting from the project. The AFCI-NERI project provided excellent support for two undergraduate and 10 graduates students at the University of Michigan during a period of three years and nine months. Significant developments were achieved in three areas: (1) Efficient deterministic fuel cycle optimization algorithms both for PWR and SFR configurations, (2) Efficient search algorithm for PWR equilibrium cycles, and (3) Simplified Excel-based script for dynamic fuel cycle analysis of diverse cycles. The project resulted in a total of 8 conference papers and three journal papers, including two that will be submitted shortly. Three pending publications are attached to the report.
Date: March 31, 2009
Creator: Lee, John C.
Object Type: Report
System: The UNT Digital Library
Final Technical Report (open access)

Final Technical Report

As proposed, the main effort in this project is the development of software capable of performing real-time monitoring of micro-seismic activity recorded by an array of sensors deployed around an EGS. The main milestones are defined by the development of software to perform the following tasks: • Real-time micro-earthquake detection and location • Real-time detection of shear-wave splitting • Delayed-time inversion of shear-wave splitting These algorithms, which are discussed in detail in this report, make possible the automatic and real-time monitoring of subsurface fracture systems in geothermal fields from data collected by an array of seismic sensors. Shear wave splitting (SWS) is parameterized in terms of the polarization of the fast shear wave and the time delay between the fast and slow shear waves, which are automatically measured and stored. The measured parameters are then combined with previously measured SWS parameters at the same station and used to invert for the orientation (strike and dip) and intensity of cracks under that station. In addition, this grant allowed the collection of seismic data from several geothermal regions in the US (Coso) and Iceland (Hengill) to use in the development and testing of the software.
Date: March 31, 2009
Creator: Rial, J.A. & Lees, J.
Object Type: Report
System: The UNT Digital Library
FLASH Beam-Off RF Measurements and Analyses (open access)

FLASH Beam-Off RF Measurements and Analyses

The FLASH L-band (1.3 GHz) superconducting accelerator facility at DESY has a Low Level RF (LLRF) system that is similar to that envisioned for ILC. This system has extensive monitoring capability and was used to gather performance data relevant to ILC. In particular, waveform data were recorded with beam off for three, 8-cavity cryomodules to evaluate the input rf stability, perturbations to the SC cavity frequencies and the rf overhead required to achieve constant gradient during the 800-s pulses. In this paper, we discuss the measurements and data analysis procedures and present key findings on the pulse-to-pulse input rf and cavity field stability.
Date: March 31, 2009
Creator: Pei, Shilun; Adolphsen, Chris & Carwardine, John
Object Type: Article
System: The UNT Digital Library
Fort Yukon, Chalkyitsik, & Venetie Biomass Boiler Feasibility Study (open access)

Fort Yukon, Chalkyitsik, & Venetie Biomass Boiler Feasibility Study

The Council of Athabascan Tribal Governments (CATG) is a consortium of ten Gwich'in and Koyukon Athabascan tribes settled in 10 remote villages and are linked by the Yukon River System. The CATG mission is to maintain the Yukon Flats region as Indian Country by asserting traditional rights and taking responsibility for developing tribal technical capacity to manage the land and resources. It is the intent of CATG to explore and develop all opportunities for a renewable and self-sufficient energy program for each of the villages. CATG envisions utilization of forest resources both for construction and energy as one of the best long-term strategies for integrating the economic goals for the region as well as supporting the cultural and social issues. The intent for this feasibility project is to focus specifically on biomass utilization for heat, first, and for future electrical generation within the region, second. An initial determination has already been made regarding the importance of wood energy as a primary source of renewable energy to displace diesel fuel in the Yukon Flats region. A desktop study of other potential renewable resources was conducted in 2006.
Date: March 31, 2009
Creator: Greg Koontz, ME William A. Wall, PhD
Object Type: Report
System: The UNT Digital Library
Functional Analysis of Arabidopsis Sucrose Transporters (open access)

Functional Analysis of Arabidopsis Sucrose Transporters

Sucrose is the main photosynthetic product that is transported in the vasculature of plants. The long-distance transport of carbohydrates is required to support the growth and development of net-importing (sink) tissues such as fruit, seeds and roots. This project is focused on understanding the transport mechanism sucrose transporters (SUTs). These are proton-coupled sucrose uptake transporters (membrane proteins) that are required for transport of sucrose in the vasculature and uptake into sink tissues. The accomplishments of this project included: 1) the first analysis of substrate specificity for any SUT. This was accomplished using electrophysiology to analyze AtSUC2, a sucrose transporter from companion cells in Arabidopsis. 2) the first analysis of the transport activity for a monocot SUT. The transport kinetics and substrate specificity of HvSUT1 from barley were studied. 3) the first analysis of a sucrose transporter from sugarcane. and 4) the first analysis of transport activity of a sugar alcohol transporter homolog from plants, AtPLT5. During this period four primary research papers, funded directly by the project, were published in refereed journals. The characterization of several sucrose transporters was essential for the current effort in the analysis of structure/function for this gene family. In particular, the demonstration of strong differences …
Date: March 31, 2009
Creator: Ward, John M.
Object Type: Report
System: The UNT Digital Library
[Funeral Program for Cloyd Carlus Winters, March 31, 2009] (open access)

[Funeral Program for Cloyd Carlus Winters, March 31, 2009]

Funeral program for Cloyd Carlus Winters, born December 29, 1938 and died March 21, 2009. The funeral was held March 31, 2009 at Bright & Morning Star Baptist Church, officiated by Pastor Sammie J. Shuler. Funeral arrangements were made by Sutton & Sutton Mortuary, Inc., and he was buried in the Fort Sam Houston National Cemetery near San Antonio, Texas.
Date: March 31, 2009
Creator: unknown
Object Type: Pamphlet
System: The Portal to Texas History
[Funeral Program for John Oscar Patin, March 31, 2009] (open access)

[Funeral Program for John Oscar Patin, March 31, 2009]

Funeral program for John Oscar Patin, born November 25, 1956. The funeral was held March 31, 2009 at F.E. Lewis Memorial Chapel, officiated by Father. Funeral arrangements were made through Lewis Funeral Home.
Date: March 31, 2009
Creator: unknown
Object Type: Pamphlet
System: The Portal to Texas History
Grande Ronde Basin Spring Chinook Salmon Captive Broodstock Program, 2008 Annual Report. (open access)

Grande Ronde Basin Spring Chinook Salmon Captive Broodstock Program, 2008 Annual Report.

The Grande Ronde Basin Spring Chinook Salmon Captive Broodstock Program is designed to rapidly increase numbers of Chinook salmon in stocks that are in imminent danger of extirpation in Catherine Creek (CC), Lostine River (LR) and upper Grande Ronde River (GR). Natural parr are captured and reared to adulthood in captivity, spawned (within stocks) and their progeny reared to smoltification before being released into the natal stream of their parents. This program is co-managed by ODFW, National Marine Fisheries Service, Nez Perce Tribe and Confederated Tribes of the Umatilla Indian Reservation. Presmolt rearing was initially conducted at Lookingglass Fish Hatchery (LFH) but parr collected in 2003 and later were reared at Wallowa Fish Hatchery (WFH). Post-smolt rearing is conducted at Bonneville Fish Hatchery (BOH - freshwater) and at Manchester Research Station (MRS - saltwater). The CC and LR programs are being terminated, as these populations have achieved the goal of a consistent return of 150 naturally spawning adults, so the 2005 brood year was the last brood year collected for theses populations. The Grande Ronde River program continued with 300 fish collected each year. Currently, we are attempting to collect 150 natural parr and incorporate 150 parr collected as eggs …
Date: March 31, 2009
Creator: Hoffnagle, Timothy L.; Hair, Donald & Gee, Sally
Object Type: Report
System: The UNT Digital Library
Grande Ronde Endemic Spring Chinook Salmon Supplementation Project; Lostine River Operations and Maintenance 2003 Smolt Acclimation and Adult Return Report. (open access)

Grande Ronde Endemic Spring Chinook Salmon Supplementation Project; Lostine River Operations and Maintenance 2003 Smolt Acclimation and Adult Return Report.

The Nez Perce Tribe (NPT), through funding provided by the Bonneville Power Administration (BPA), has implemented a Chinook salmon supplementation program (250,000 smolts) on the Lostine River, a tributary to the Grande Ronde River of Oregon. The Grande Ronde Endemic Spring Chinook Salmon Supplementation project, which involves supplementation of the Upper Grande Ronde River and Catherine Creek in addition to the Lostine River, was established to prevent extirpation and increase the number of threatened Snake River spring/summer Chinook salmon (Oncorhynchus tshawytscha) returning to the Grande Ronde River. This report covers the seventh season (1997-2003) of adult Chinook salmon broodstock collection in the Lostine River and the fifth season (1999-2003) of acclimating the resultant progeny. Production of Lostine River spring Chinook salmon smolts currently occurs at Lookingglass Fish Hatchery (LGH). The Lostine River supplementation program utilizes two strategies to obtain egg source for production of smolts for supplementation: captive broodstock and conventional broodstock. The captive broodstock strategy involves (1) capture of natural juvenile spring Chinook salmon smolts from the Lostine River, (2) rearing those to adult and spawning them, and (3) rearing the resultant progeny for eventual acclimation and release back into the Lostine River. The conventional broodstock strategy involves (1) …
Date: March 31, 2009
Creator: Zollman, Richard L.; Eschler, Russell & Sealey, Shawn
Object Type: Report
System: The UNT Digital Library
Grande Ronde Endemic Spring Chinook Salmon Supplementation Project; Lostine River Operations and Maintenance 2004 Smolt Acclimation and Adult Return Report. (open access)

Grande Ronde Endemic Spring Chinook Salmon Supplementation Project; Lostine River Operations and Maintenance 2004 Smolt Acclimation and Adult Return Report.

The Nez Perce Tribe (NPT), through funding provided by the Bonneville Power Administration (BPA), has implemented a Chinook salmon supplementation program (250,000 smolts) on the Lostine River, a tributary to the Grande Ronde River of Oregon. The Grande Ronde Endemic Spring Chinook Salmon Supplementation project, which involves supplementation of the Upper Grande Ronde River and Catherine Creek in addition to the Lostine River, was established to prevent extirpation and increase the number of threatened Snake River spring/summer Chinook salmon (Oncorhynchus tshawytscha) returning to the Grande Ronde River. This report covers the eighth season (1997-2004) of adult Chinook salmon broodstock collection in the Lostine River and the sixth season (1999-2004) of acclimation of resulting Lostine River progeny. Production of Lostine River spring Chinook salmon smolts currently occurs at Lookingglass Fish Hatchery (LGH). The Lostine River supplementation program utilizes two strategies to obtain egg source for production of smolts for supplementation: captive broodstock and conventional broodstock. The captive broodstock strategy involves (1) capture of natural juvenile spring Chinook salmon smolts from the Lostine River, (2) rearing those to adult and spawning them, and (3) rearing the resultant progeny for eventual acclimation and release back into the Lostine River. The conventional broodstock strategy …
Date: March 31, 2009
Creator: Zollman, Richard L.; Eschler, Russell & Sealey, Shawn
Object Type: Report
System: The UNT Digital Library
Grande Ronde Endemic Spring Chinook Salmon Supplementation Project; Lostine River Operations and Maintenance 2006 Smolt Acclimation and Adult Return Report. (open access)

Grande Ronde Endemic Spring Chinook Salmon Supplementation Project; Lostine River Operations and Maintenance 2006 Smolt Acclimation and Adult Return Report.

The Nez Perce Tribe (NPT), through funding provided by the Bonneville Power Administration (BPA), has implemented a Chinook salmon supplementation program (250,000 smolts) on the Lostine River, a tributary to the Grande Ronde River of Oregon. The Grande Ronde Endemic Spring Chinook Salmon Supplementation project, which involves supplementation of the Upper Grande Ronde River and Catherine Creek in addition to the Lostine River, was established to prevent extirpation and increase the number of threatened Snake River spring/summer Chinook salmon (Oncorhynchus tshawytscha) returning to the Grande Ronde River. This report covers the tenth season (1997-2006) of adult Chinook salmon broodstock collection in the Lostine River and the eighth season (1999-2006) of acclimation of resulting Lostine River progeny. Production of Lostine River spring Chinook salmon smolts currently occurs at Lookingglass Fish Hatchery (LGH). The Lostine River supplementation program utilizes two strategies to obtain egg source for production of smolts for supplementation: captive broodstock and conventional broodstock. The captive broodstock strategy involves (1) capture of natural juvenile spring Chinook salmon smolts from the Lostine River, (2) rearing those to adult and spawning them, and (3) rearing the resultant progeny for eventual acclimation and release back into the Lostine River. The conventional broodstock strategy …
Date: March 31, 2009
Creator: Zollman, Richard L.; Eschler, Russell & Sealey, Shawn
Object Type: Report
System: The UNT Digital Library
Grande Ronde Endemic Spring Chinook Salmon Supplementation Project; Lostine River Operations and Maintenance 2007 Smolt Acclimation and Adult Return Report. (open access)

Grande Ronde Endemic Spring Chinook Salmon Supplementation Project; Lostine River Operations and Maintenance 2007 Smolt Acclimation and Adult Return Report.

The Nez Perce Tribe (NPT), through funding provided by the Bonneville Power Administration (BPA), has implemented a Chinook salmon supplementation program (250,000 smolts) on the Lostine River, a tributary to the Grande Ronde River of Oregon. The Grande Ronde Endemic Spring Chinook Salmon Supplementation project, which involves supplementation of the Upper Grande Ronde River and Catherine Creek in addition to the Lostine River, was established to prevent extirpation and increase the number of threatened Snake River spring/summer Chinook salmon (Oncorhynchus tshawytscha) returning to the Grande Ronde River. This report covers the eleventh season (1997-2007) of adult Chinook salmon broodstock collection in the Lostine River and the ninth season (1999-2007) of acclimation of resulting Lostine River progeny. Production of Lostine River spring Chinook salmon smolts currently occurs at Lookingglass Fish Hatchery (LGH). The Lostine River supplementation program utilizes two strategies to obtain egg source for production of smolts for supplementation: captive broodstock and conventional broodstock. The captive broodstock strategy involves (1) capture of natural juvenile spring Chinook salmon smolts from the Lostine River, (2) rearing those to adult and spawning them, and (3) rearing the resultant progeny for eventual acclimation and release back into the Lostine River. The conventional broodstock strategy …
Date: March 31, 2009
Creator: Zollman, Richard L.; Eschler, Russell & Sealey, Shawn
Object Type: Report
System: The UNT Digital Library
Greensheet (Houston, Tex.), Vol. 40, No. 97, Ed. 1 Tuesday, March 31, 2009 (open access)

Greensheet (Houston, Tex.), Vol. 40, No. 97, Ed. 1 Tuesday, March 31, 2009

Free weekly newspaper that includes business and classified advertising.
Date: March 31, 2009
Creator: unknown
Object Type: Newspaper
System: The Portal to Texas History
Greensheet (Houston, Tex.), Vol. 40, No. 98, Ed. 1 Tuesday, March 31, 2009 (open access)

Greensheet (Houston, Tex.), Vol. 40, No. 98, Ed. 1 Tuesday, March 31, 2009

Free weekly newspaper that includes business and classified advertising.
Date: March 31, 2009
Creator: unknown
Object Type: Newspaper
System: The Portal to Texas History
HEAVY ION FUSION SCIENCE VIRTUALNATIONAL LABORATORY 2nd QUARTER 2009 MILESTONE REPORT: Perform beam and target experiments with a new induction bunching module, extended FEPS plasma, and improved target diagnostic and positioning equipment on NDCX (open access)

HEAVY ION FUSION SCIENCE VIRTUALNATIONAL LABORATORY 2nd QUARTER 2009 MILESTONE REPORT: Perform beam and target experiments with a new induction bunching module, extended FEPS plasma, and improved target diagnostic and positioning equipment on NDCX

This effort contains two main components: The new induction-bunching module is expected to deliver higher fluence in the bunched beam, and the new target positioner will enable a significantly enhanced target physics repetition rate. The velocity ramp that bunches the K{sup +} beam in the neutralized drift compression section is established with a bipolar voltage ramp applied to an acceleration gap. An induction acceleration module creates this voltage waveform. The new bunching module (IBM) specially built for NDCX has approximately twice the capability (volt-seconds) as our original IBM. We reported on the beam line design for the best use of the bunching module in our FY08 Q2 report. Based on simulations and theoretical work, we chose to extend the drift compression section and use the additional volt-seconds to extend the pulse duration and keep the peak voltage swing (and velocity excursions) similar to the present module. Simulations showed that this approach, which extends the drift section, to be advantageous because it limits the chromatic aberrations in the beam spot on target. To this end, colleagues at PPPL have fabricated the meter-long extension to the ferroelectric plasma source and it was installed on the beam line with the new IBM in …
Date: March 31, 2009
Creator: Bieniosek, F. M.; Anders, A.; Barnard, J. J.; Dickinson, M. R.; Gilson, E.; Greenway, W. et al.
Object Type: Report
System: The UNT Digital Library
Heterogeneous Reburning By Mixed Fuels (open access)

Heterogeneous Reburning By Mixed Fuels

Recent studies of heterogeneous reburning, i.e., reburning involving a coal-derived char, have elucidated its variables, kinetics and mechanisms that are valuable to the development of a highly efficient reburning process. Young lignite chars contain catalysts that not only reduce NO, but they also reduce HCN that is an important intermediate that recycles to NO in the burnout zone. Gaseous CO scavenges the surface oxides that are formed during NO reduction, regenerating the active sites on the char surface. Based on this mechanistic information, cost-effective mixed fuels containing these multiple features has been designed and tested in a simulated reburning apparatus. Remarkably high reduction of NO and HCN has been observed and it is anticipated that mixed fuel will remove 85% of NO in a three-stage reburning process.
Date: March 31, 2009
Creator: Hall, Anderson
Object Type: Report
System: The UNT Digital Library
Improving Geologic and Engineering Models of Midcontinent Fracture and Karst-Modified Reservoirs Using New 3-D Seismic Attributes (open access)

Improving Geologic and Engineering Models of Midcontinent Fracture and Karst-Modified Reservoirs Using New 3-D Seismic Attributes

Our project goal was to develop innovative seismic-based workflows for the incremental recovery of oil from karst-modified reservoirs within the onshore continental United States. Specific project objectives were: (1) to calibrate new multi-trace seismic attributes (volumetric curvature, in particular) for improved imaging of karst-modified reservoirs, (2) to develop attribute-based, cost-effective workflows to better characterize karst-modified carbonate reservoirs and fracture systems, and (3) to improve accuracy and predictiveness of resulting geomodels and reservoir simulations. In order to develop our workflows and validate our techniques, we conducted integrated studies of five karst-modified reservoirs in west Texas, Colorado, and Kansas. Our studies show that 3-D seismic volumetric curvature attributes have the ability to re-veal previously unknown features or provide enhanced visibility of karst and fracture features compared with other seismic analysis methods. Using these attributes, we recognize collapse features, solution-enlarged fractures, and geomorphologies that appear to be related to mature, cockpit landscapes. In four of our reservoir studies, volumetric curvature attributes appear to delineate reservoir compartment boundaries that impact production. The presence of these compartment boundaries was corroborated by reservoir simulations in two of the study areas. Based on our study results, we conclude that volumetric curvature attributes are valuable tools for mapping …
Date: March 31, 2009
Creator: Nissen, Susan; Bhattacharya, Saibal; Watney, W. Lynn & Doveton, John
Object Type: Report
System: The UNT Digital Library
Integrated analysis of breast cancer cell lines reveals unique signaling pathways (open access)

Integrated analysis of breast cancer cell lines reveals unique signaling pathways

Cancer is a heterogeneous disease resulting from the accumulation of genetic defects that negatively impact control of cell division, motility, adhesion and apoptosis. Deregulation in signaling along the EGFR-MAPK pathway is common in breast cancer, though the manner in which deregulation occurs varies between both individuals and cancer subtypes. We were interested in identifying subnetworks within the EGFR-MAPK pathway that are similarly deregulated across subsets of breast cancers. To that end, we mapped genomic, transcriptional and proteomic profiles for 30 breast cancer cell lines onto a curated Pathway Logic symbolic systems model of EGFR-MEK signaling. This model was comprised of 539 molecular states and 396 rules governing signaling between active states. We analyzed these models and identified several subtype specific subnetworks, including one that suggested PAK1 is particularly important in regulating the MAPK cascade when it is over-expressed. We hypothesized that PAK1 overexpressing cell lines would have increased sensitivity to MEK inhibitors. We tested this experimentally by measuring quantitative responses of 20 breast cancer cell lines to three MEK inhibitors. We found that PAK1 over-expressing luminal breast cancer cell lines are significantly more sensitive to MEK inhibition as compared to those that express PAK1 at low levels. This indicates that …
Date: March 31, 2009
Creator: Heiser, Laura M.; Wang, Nicholas J.; Talcott, Carolyn L.; Laderoute, Keith R.; Knapp, Merrill; Guan, Yinghui et al.
Object Type: Article
System: The UNT Digital Library
An Integrated Solid-State LED Luminaire for General Lighting (open access)

An Integrated Solid-State LED Luminaire for General Lighting

A strong systems approach to designing and building practical LED-based replacement lamps is lacking. The general method of taking high-performance LEDs and marrying them to standard printed circuit boards, drivers and a heat sink has fallen short of the promise of LED lighting. In this program, a top-down assessment of requirements and a bottom-up reinvention of LED sources, electronics, optics and mechanics have resulted in the highest performance lamp possible. The team, comprised of Color Kinetics, the leaders in LED lighting and Cree, the leaders in LED devices took an approach to reinvent the package, the driver and the overall form and aesthetic of a replacement source. The challenge was to create a new benchmark in LED lighting - the resultant lamp, a PAR38 equivalent, met the light output, color, color quality and efficacy marks set out in the program as well as being dimmable, which is important for market acceptance. The approach combined the use of multiple source die, a chip-on-board approach, a very efficient driver topology, the use of both direct emission and phosphor conversion, and a unique faceted optic to avoid the losses, artifacts and hotspots of lensed approaches. The integral heat sink provided a mechanical base …
Date: March 31, 2009
Creator: Dowling, Kevin; Lys, Fritz Morgan Ihor; Datta, Mike; Keller, Bernd & Yuan, Thomas
Object Type: Report
System: The UNT Digital Library