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Methadone-Associated Overdose Deaths: Factors Contributing to Increased Deaths and Efforts to Prevent Them (open access)

Methadone-Associated Overdose Deaths: Factors Contributing to Increased Deaths and Efforts to Prevent Them

A letter report issued by the Government Accountability Office with an abstract that begins "Prescription drug abuse is a growing public health problem. In particular, methadone-associated overdose deaths--those in which methadone may have caused or contributed to the death--have risen sharply. Before the late 1990s, methadone was used mainly to treat opioid addiction but has since been increasingly prescribed to manage pain. Taken too often, in too high a dose, or with other drugs or alcohol, methadone can cause serious side effects and death. Methadone-associated overdose deaths can occur under several different scenarios, including improper dosing levels by practitioners, misuse by patients who may combine methadone with other drugs, or abuse--using the drug for nontherapeutic purposes. This report examines the regulation of methadone, factors that have contributed to the increase in methadone-associated overdose deaths, and steps taken to prevent methadone-associated overdose deaths. GAO reviewed documents, laws and regulations, data, and research from relevant state and federal agencies, including the Drug Enforcement Administration (DEA) and the Substance Abuse and Mental Health Services Administration (SAMHSA). GAO also interviewed federal officials, officials in five selected states, officials from professional associations and advocacy groups, and experts in pain management, addiction treatment, and forensic sciences."
Date: March 26, 2009
Creator: United States. Government Accountability Office.
Object Type: Report
System: The UNT Digital Library
Defense Management: Key Challenges Should be Addressed When Considering Changes to Missile Defense Agency's Roles and Missions (open access)

Defense Management: Key Challenges Should be Addressed When Considering Changes to Missile Defense Agency's Roles and Missions

Testimony issued by the Government Accountability Office with an abstract that begins "To more quickly field ballistic missile defenses, the Missile Defense Agency (MDA) has been exempted from traditional Department of Defense (DOD) requirements development, acquisition, and oversight processes since its creation in 2002. Instead, MDA has unique roles and missions to develop and field weapon systems that address a variety of ballistic missile threats. To date, MDA has spent about $56 billion and plans to spend about $50 billion more through 2013 to develop an integrated Ballistic Missile Defense System. The system consists of a layered network of capabilities that includes defensive components such as sensors, radars, interceptors, and command and control. In reviews of DOD's approach to acquire, operate, and maintain ballistic missile defense systems, GAO has previously reported on several challenges that have stemmed from the broad flexibilities provided to MDA. This testimony summarizes the challenges facing DOD in acquiring and operating its ballistic missile defense systems and describes DOD's efforts to improve transparency and accountability. This statement is based primarily on previously issued GAO reports and testimonies. GAO also reviewed documents and interviewed key officials to update past work and identify DOD and MDA efforts to …
Date: March 26, 2009
Creator: United States. Government Accountability Office.
Object Type: Text
System: The UNT Digital Library
Human Subjects Research: Undercover Tests Show the Institutional Review Board System Is Vulnerable to Unethical Manipulation (open access)

Human Subjects Research: Undercover Tests Show the Institutional Review Board System Is Vulnerable to Unethical Manipulation

Testimony issued by the Government Accountability Office with an abstract that begins "Millions of Americans enroll in clinical studies of experimental drugs and medical devices each year. Many of these studies are meant to demonstrate that products are safe and effective. The Department of Health and Human Services' (HHS) Office for Human Research Protections (OHRP) and the Food and Drug Administration (FDA) are responsible for overseeing aspects of a system of independent institutional review boards (IRB). IRBs review and monitor human subjects research, with the intended purpose of protecting the rights and welfare of the research subjects. GAO investigated three key aspects of the IRB system: (1) the process for establishing an IRB, (2) the process through which researchers wishing to apply for federal funding assure HHS their human subjects research activities follow ethical principles and federal regulations, and (3) the process that medical research companies follow to get approval for conducting research on human subjects. GAO investigated these three aspects of the IRB system by creating two fictitious companies (one IRB and one medical device company), phony company officials, counterfeit documents, and a fictitious medical device."
Date: March 26, 2009
Creator: United States. Government Accountability Office.
Object Type: Text
System: The UNT Digital Library
Port Aransas South Jetty (Port Aransas, Tex.), Vol. 39, No. 13, Ed. 1 Thursday, March 26, 2009 (open access)

Port Aransas South Jetty (Port Aransas, Tex.), Vol. 39, No. 13, Ed. 1 Thursday, March 26, 2009

Weekly newspaper from Port Aransas, Texas on Mustang Island that includes local, state and national news along with extensive advertising.
Date: March 26, 2009
Creator: Judson, Mary Henkel
Object Type: Newspaper
System: The Portal to Texas History
Greensheet (Houston, Tex.), Vol. 40, No. 93, Ed. 1 Thursday, March 26, 2009 (open access)

Greensheet (Houston, Tex.), Vol. 40, No. 93, Ed. 1 Thursday, March 26, 2009

Free weekly newspaper that includes business and classified advertising.
Date: March 26, 2009
Creator: unknown
Object Type: Newspaper
System: The Portal to Texas History
Greensheet (Houston, Tex.), Vol. 40, No. 92, Ed. 1 Thursday, March 26, 2009 (open access)

Greensheet (Houston, Tex.), Vol. 40, No. 92, Ed. 1 Thursday, March 26, 2009

Free weekly newspaper that includes business and classified advertising.
Date: March 26, 2009
Creator: unknown
Object Type: Newspaper
System: The Portal to Texas History
[Clipping: Female pilot supports Stewart's mission] (open access)

[Clipping: Female pilot supports Stewart's mission]

Newspaper clipping of an article about former WASP member Helen Wyatt Snapp's experiences serving as a pilot in WWII. The clipping includes other articles about local and world news, as well as advertisements.
Date: March 26, 2009
Creator: Van Pool, J. Elise
Object Type: Clipping
System: The Portal to Texas History
North Texas Daily (Denton, Tex.), Vol. 93, No. 34, Ed. 1 Thursday, March 26, 2009 (open access)

North Texas Daily (Denton, Tex.), Vol. 93, No. 34, Ed. 1 Thursday, March 26, 2009

Daily student newspaper from the University of North Texas in Denton, Texas that includes local, state and campus news along with advertising.
Date: March 26, 2009
Creator: unknown
Object Type: Newspaper
System: The Portal to Texas History
Texas Jewish Post (Fort Worth, Tex.), Vol. 63, No. 13, Ed. 1 Thursday, March 26, 2009 (open access)

Texas Jewish Post (Fort Worth, Tex.), Vol. 63, No. 13, Ed. 1 Thursday, March 26, 2009

Weekly Jewish newspaper from Fort Worth, Texas that includes local, state and national news along with extensive advertising.
Date: March 26, 2009
Creator: Wisch, Rene
Object Type: Newspaper
System: The Portal to Texas History
The Canadian Record (Canadian, Tex.), Vol. 119, No. 13, Ed. 1 Thursday, March 26, 2009 (open access)

The Canadian Record (Canadian, Tex.), Vol. 119, No. 13, Ed. 1 Thursday, March 26, 2009

Weekly newspaper from Canadian, Texas that includes local, state and national news along with some advertising.
Date: March 26, 2009
Creator: Brown, Laurie Ezzell
Object Type: Newspaper
System: The Portal to Texas History
The Bastrop Advertiser (Bastrop, Tex.), Vol. 156, No. 7, Ed. 1 Thursday, March 26, 2009 (open access)

The Bastrop Advertiser (Bastrop, Tex.), Vol. 156, No. 7, Ed. 1 Thursday, March 26, 2009

Semi-weekly newspaper from Bastrop, Texas that includes local, state and national news along with advertising.
Date: March 26, 2009
Creator: Wright, Cyndi
Object Type: Newspaper
System: The Portal to Texas History
[ActBlue Texas Stonewall Democratic Caucus reporting center] (open access)

[ActBlue Texas Stonewall Democratic Caucus reporting center]

A report for the Texas Stonewall Democratic Caucus from their account with ActBlue. The report lists contribution summary of committee's contributions and fundraisers.
Date: March 26, 2009
Creator: unknown
Object Type: Report
System: The UNT Digital Library
Greensheet (Fort Worth, Tex.), Vol. 32, No. 355, Ed. 1 Thursday, March 26, 2009 (open access)

Greensheet (Fort Worth, Tex.), Vol. 32, No. 355, Ed. 1 Thursday, March 26, 2009

Free weekly newspaper that includes business and classified advertising.
Date: March 26, 2009
Creator: unknown
Object Type: Newspaper
System: The Portal to Texas History
Today Newspapers (Duncanville, Tex.), Vol. 1, No. 2, Ed. 1 Thursday, March 26, 2009 (open access)

Today Newspapers (Duncanville, Tex.), Vol. 1, No. 2, Ed. 1 Thursday, March 26, 2009

Weekly newspaper from Duncanville, Texas that includes local, state, and national news along with advertising.
Date: March 26, 2009
Creator: unknown
Object Type: Newspaper
System: The Portal to Texas History
The Greensheet (Arlington-Grand Prairie, Tex.), Vol. 32, No. 353, Ed. 1 Thursday, March 26, 2009 (open access)

The Greensheet (Arlington-Grand Prairie, Tex.), Vol. 32, No. 353, Ed. 1 Thursday, March 26, 2009

Free weekly newspaper that includes business and classified advertising.
Date: March 26, 2009
Creator: unknown
Object Type: Newspaper
System: The Portal to Texas History
Greensheet (Fort Worth, Tex.), Vol. 32, No. 354, Ed. 1 Thursday, March 26, 2009 (open access)

Greensheet (Fort Worth, Tex.), Vol. 32, No. 354, Ed. 1 Thursday, March 26, 2009

Free weekly newspaper that includes business and classified advertising.
Date: March 26, 2009
Creator: unknown
Object Type: Newspaper
System: The Portal to Texas History
Annual Site Environmental Report for Calendar Year 2004 (open access)

Annual Site Environmental Report for Calendar Year 2004

This report provides the U.S. Department of Energy (DOE) and the public with information on the level of radioactive and non-radioactive pollutants (if any) that are added to the environment as a result of Princeton Plasma Physics Laboratory's (PPPL) operations. The results of the 2004 environmental surveillance and monitoring program for PPPL's are presented and discussed. The report also summarizes environmental initiatives, assessments, and programs that were undertaken in 2004.
Date: March 26, 2009
Creator: Finley, V.
Object Type: Report
System: The UNT Digital Library
Laser Ablation-Inductively Coupled Plasma-Atomic Emission Spectroscopy Study at the 222-S Laboratory Using Hot-Cell Glove Box Prototype System (open access)

Laser Ablation-Inductively Coupled Plasma-Atomic Emission Spectroscopy Study at the 222-S Laboratory Using Hot-Cell Glove Box Prototype System

This report describes the installation, testing and acceptance of the Waste Treatment and Immobilization Plant procured laser ablation-inductively coupled plasma-atomic emission spectroscopy (LA-ICP-AES) system for remotely analyzing high-level waste samples in a hot cell environment. The 2005-003; ATS MP 1027, Management Plan for Waste Treatment Plant Project Work Performed by Analytical Technical Services. The APD group at the 222-S laboratory demonstrated acceptable turnaround time (TAT) and provide sufficient data to assess sensitivity, accuracy, and precision of the LA-ICP-AES method.
Date: March 26, 2009
Creator: Lockrem, L. L.; Owens, J. W. & Seidel, C. M.
Object Type: Report
System: The UNT Digital Library
Silicon Carbide Ceramics for Compact Heat Exchangers (open access)

Silicon Carbide Ceramics for Compact Heat Exchangers

Silicon carbide (SiC) materials are prime candidates for high temperature heat exchangers for next generation nuclear reactors due to their refractory nature and high thermal conductivity at elevated temperatures. This research has focused on demonstrating the potential of liquid silicon infiltration (LSI) for making SiC to achieve this goal. The major advantage of this method over other ceramic processing techniques is the enhanced capability of making high dense, high purity SiC materials in complex net shapes. For successful formation of net shape SiC using LSI techniques, the carbon preform reactivity and pore structure must be controlled to allow the complete infiltration of the porous carbon structure which allows complete conversion of the carbon to SiC. We have established a procedure for achieving desirable carbon properties by using carbon precursors consisting of two readily available high purity organic materials, crystalline cellulose and phenolic resin. Phenolic resin yields a glassy carbon with low chemical reactivity and porosity while the cellulose carbon is highly reactive and porous. By adjusting the ratio of these two materials in the precursor mixtures, the properties of the carbons produced can be controlled. We have identified the most favorable carbon precursor composition to be a cellulose resin mass …
Date: March 26, 2009
Creator: Nagle, Dennis & Zhang, Dajie
Object Type: Report
System: The UNT Digital Library
Collins Fragmentation and the Single Transverse Spin Asymmetry (open access)

Collins Fragmentation and the Single Transverse Spin Asymmetry

We study the Collins mechanism for the single transverse spin asymmetry in the collinear factorization approach. The correspondent twist-three fragmentation function is identified. We show that the Collins function calculated in this approach is universal.We further examine its contribution to the single transverse spin asymmetry of semi-inclusive hadron production in deep inelastic scattering and demonstrate that the transverse momentum dependent and twist-three collinear approaches are consistent in the intermediate transverse momentum region where both apply.
Date: March 26, 2009
Creator: Yuan, Feng & Zhou, Jian
Object Type: Article
System: The UNT Digital Library
Study of Turbulent Fluctuations Driven by the Electron Temperature Gradient in the National Spherical Torus Experiment (open access)

Study of Turbulent Fluctuations Driven by the Electron Temperature Gradient in the National Spherical Torus Experiment

Various theories and numerical simulations support the conjecture that the ubiquitous problem of anomalous electron transport in tokamaks may arise from a short-scale turbulence driven by the electron temperature gradient. To check whether this turbulence is present in plasmas of the National Spherical Torus Experiment (NSTX), measurements of turbulent fluctuations were performed with coherent scattering of electromagnetic waves. Results from plasmas heated by high harmonic fast waves (HHFW) show the existence of density fluctuations in the range of wave numbers k⊥ρe=0.1-0.4, corresponding to a turbulence scale length of the order of the collisionless skin depth. Experimental observations and agreement with numerical results from the linear gyro-kinetic GS2 code indicate that the observed turbulence is driven by the electron temperature gradient. These turbulent fluctuations were not observed at the location of an internal transport barrier driven by a negative magnetic shear.
Date: March 26, 2009
Creator: Mazzucato, E.; Bell, R. E.; Ethier, S.; Hosea, J. C.; Kaye, S. M.; LeBlanc, B. P. et al.
Object Type: Report
System: The UNT Digital Library
Advanced Dark Energy Physics Telescope (ADEPT) (open access)

Advanced Dark Energy Physics Telescope (ADEPT)

In 2006, we proposed to NASA a detailed concept study of ADEPT (the Advanced Dark Energy Physics Telescope), a potential space mission to reliably measure the time-evolution of dark energy by conducting the largest effective volume survey of the universe ever done. A peer-review panel of scientific, management, and technical experts reported back the highest possible 'excellent' rating for ADEPT. We have since made substantial advances in the scientific and technical maturity of the mission design. With this Department of Energy (DOE) award we were granted supplemental funding to support specific extended research items that were not included in the NASA proposal, many of which were intended to broadly advance future dark energy research, as laid out by the Dark Energy Task Force (DETF). The proposed work had three targets: (1) the adaptation of large-format infrared arrays to a 2 micron cut-off; (2) analytical research to improve the understanding of the dark energy figure-of- merit; and (3) extended studies of baryon acoustic oscillation systematic uncertainties. Since the actual award was only for {approx}10% of the proposed amount item (1) was dropped and item (2) work was severely restricted, consistent with the referee reviews of the proposal, although there was considerable …
Date: March 26, 2009
Creator: Bennett, Charles L.
Object Type: Report
System: The UNT Digital Library
Timpson & Tenaha News (Timpson, Tex.), Vol. 27, No. 12, Ed. 1 Thursday, March 26, 2009 (open access)

Timpson & Tenaha News (Timpson, Tex.), Vol. 27, No. 12, Ed. 1 Thursday, March 26, 2009

Weekly newspaper from Timpson, Texas that includes local, state, and national news along with advertising.
Date: March 26, 2009
Creator: Alexander, Nancy
Object Type: Newspaper
System: The Portal to Texas History
Cooper Review (Cooper, Tex.), Vol. 129, No. 13, Ed. 1 Thursday, March 26, 2009 (open access)

Cooper Review (Cooper, Tex.), Vol. 129, No. 13, Ed. 1 Thursday, March 26, 2009

Weekly newspaper from Cooper, Texas that includes local, state, and national news along with advertising.
Date: March 26, 2009
Creator: Palmer, Roger
Object Type: Newspaper
System: The Portal to Texas History