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A crucial step in human breast cancer progression is the acquisition of invasiveness. There is a distinct lack of human cell culture models to study the transition from pre-invasive to invasive phenotype as it may occur 'spontaneously' in vivo. To delineate molecular alterations important for this transition, we isolated human breast epithelial cell lines that showed partial loss of tissue polarity in three-dimensional reconstituted-basement membrane cultures. These cells remained non-invasive; however, unlike their non-malignant counterparts, they exhibited a high propensity to acquire invasiveness through basement membrane in culture. The genomic aberrations and gene expression profiles of the cells in this model showed a high degree of similarity to primary breast tumor profiles. The xenograft tumors formed by the cell lines in three different microenvironments in nude mice displayed metaplastic phenotypes, including squamous and basal characteristics, with invasive cells exhibiting features of higher grade tumors. To find functionally significant changes in transition from pre-invasive to invasive phenotype, we performed attribute profile clustering analysis on the list of genes differentially expressed between pre-invasive and invasive cells. We found integral membrane proteins, transcription factors, kinases, transport molecules, and chemokines to be highly represented. In addition, expression of matrix metalloproteinases MMP-9,-13,-15,-17 was up regulated …

Recital presented at the UNt College of Music Recital Hall in partial fulfillment of the Bachelor of Music (BM) degree.

Daily newspaper from Altus, Oklahoma that includes local, state, and national news along with advertising.

Daily newspaper from Baytown, Texas that includes local, state, and national news along with advertising.

The Integrated Status and Effectiveness Monitoring Program (ISEMP-BPA project No.2003-0017) has been created as a cost effective means of developing protocols and new technologies, novel indicators, sample designs, analytical, data management and communication tools and skills, and restoration experiments that support the development of a region-wide Research, Monitoring and Evaluation (RME) program to assess the status of anadromous salmonid populations, their tributary habitat and restoration and management actions. The most straightforward approach to developing a regional-scale monitoring and evaluation program would be to increase standardization among status and trend monitoring programs. However, the diversity of species and their habitat, as well as the overwhelming uncertainty surrounding indicators, metrics, and data interpretation methods, requires the testing of multiple approaches. Thus, the approach ISEMP has adopted is to develop a broad template that may differ in the details among subbasins, but one that will ultimately lead to the formation of a unified RME process for the management of anadromous salmonid populations and habitat across the Columbia River Basin. ISEMP has been initiated in three pilot subbasins, the Wenatchee/Entiat, John Day, and Salmon. To balance replicating experimental approaches with the goal of developing monitoring and evaluation tools that apply as broadly as possible …

The physical and electrochemical properties of LixMnO2 and LixTi0.11Mn0.89O2 synthesized from precursors made by glycine-nitrate combustion (GNC) and solid-state synthesis methods (SS) are examined in this paper. The highest specific capacities in lithium cells are obtained for SS-LixMnO2 electrodes at low current densities, but GNC-LixTi0.11Mn0.89O2 electrodes show the best high rate performance. These results can be explained by changes in the voltage characteristics and differences in the particle morphologies induced by the Ti-substitution and synthesis method. Ti-substitution also results in a decrease in the electronic conductivity, but greatly improves the thermal properties and imparts dissolution resistance to the electrode. For these reasons, it is preferable to use LixTi0.11MnO0.89O2 in lithium battery configurations rather than LixMnO2. Suggestions for improving the electrochemical performance of the Ti-substituted variant are given based on the results described herein.

This report gives an overview of what "wilderness" means in the United States based on the Wilderness Act enacted by Congress in 1964. It also includes information about wilderness usage and statistics.

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This report is about Averting a Financial crisis.

In April 2003, the sequence of the human genome was deposited into public databases. This milestone, which has been compared to the discoveries of Galileo, and other advances in genetics have created novel legal issues relating to genetic information. This report discusses current federal law, state statutes, and legislation related to these issues.

The authors measure the time-dependent CP asymmetry parameters in B{sup 0} {yields} K{sup +}K{sup -}K{sup 0} based on a data sample of approximately 277 million B-meson pairs recorded at the {Upsilon}(4S) resonance with the BABAR detector at the PEP-II B-meson Factory at SLAC. They reconstruct two-body B{sup 0} decays to {phi}(1020)K{sub s}{sup 0} and {phi}(1020)K{sub L}{sup 0}. Using a time-dependent maximum-likelihood fit, they measure sin2{beta}{sub eff}({phi}K{sup 0}) = 0.48 {+-} 0.28 {+-} 0.10, and C({phi}K{sup 0}) = 0.16 {+-} 0.25 {+-} 0.09, where the first error is statistical, and the second is systematic. They also present measurements of the CP-violating asymmetries in the decay B{sup 0} {yields} f{sub 0}({yields} {pi}{sup +}{pi}{sup -})K{sub s}{sup 0}. The results are obtained from a data sample of 209 x 10{sup 6} {Upsilon}(4S) {yields} B{bar B} decays, also collected with the BABAR detector at the PEP-II asymmetric-energy B Factory at SLAC. From a time-dependent maximum-likelihood fit they measure the mixing-induced CP violation parameter S(f{sub 0}(980)K{sub S}{sup 0}) = - sin 2{beta}{sub eff}f{sub 0}(980)K{sub S}{sup 0} = -0.95{sub -0.23}{sup +0.32} {+-} 0.10 and the direct CP violation parameter C(f{sub 0}(980)K{sub S}{sup 0}) = - 0.24 {+-} 0.31 {+-} 0.15, where the first errors are statistical and …

The traditional first aerosol indirect effect or the Twomey effect involves several fundamental assumptions. Some of the assumptions (e.g., constant liquid water content) are explicitly stated in studies of the Twomey effect whereas others are only implicitly embedded in the quantitative formulation. This work focuses on examining the implicit assumptions. In particular, we will show that anthropogenic pollution not only increases aerosol loading and droplet concentrations but also alters the relative dispersions of both the aerosol and subsequent droplet size distributions. The indirect effects resulting from the two altered relative dispersions (aerosol dispersion effect and droplet dispersion effect) are likely opposite in sign and proportional in magnitude to the conventional Twomey effect. This result suggests that the outstanding problems of the Twomey effect (i.e., large uncertainty and overestimation reported in literature) may lie with violation of the constant spectral shapes of aerosol and droplet size distributions implicitly assumed in evaluation of the Twomey effect, and therefore, further progress in understanding and quantification of the first aerosol indirect effect demands moving beyond the traditional paradigm originally conceived by Twomey.

Recital presented at the UNT College of Music Concert Hall in partial fulfillment of the Doctor of Musical Arts (DMA) degree.

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When a networked polymeric composite under high stress is subjected to irradiation, the resulting chemical changes like chain scissioning and cross-link formation can lead to permanent set and altered elastic modulus. Using a commercial silicone elastomer as a specific example we show that a simple 2-stage Tobolsky model in conjunction with Fricker's stress-transfer function can quantitatively reproduce all experimental data as a function of radiation dosage and the static strain at which radiation is turned on, including permanent set, stress-strain response, and net cross-linking density.

Daily newspaper from Sapulpa, Oklahoma that includes local, state, and national news along with advertising.

Photograph of Bill Hartman standing at a wooden podium and addressing the guests in attendance at the 2008 Texas Daily Newspaper Association annual conference awards dinner, held at The Westin Riverwalk Hotel in San Antonio, Texas.

Photograph of Charles Moser (right) standing and chatting with two women, one identified as Peggy (center), dressed in their finest attire, in attendance at the 2008 Texas Daily Newspaper Association annual conference awards dinner, held at The Westin Riverwalk Hotel in San Antonio, Texas.

Photograph of Charles Moser standing at a wooden podium and addressing the guests, giving a thank you speech as he has accepted an award, at the 2008 Texas Daily Newspaper Association annual conference awards dinner, held at The Westin Riverwalk Hotel in San Antonio, Texas.

Photograph of Cliff Clements (left) and Neice Bell (right) seen standing at a cocktail table and drinking refreshments, dressed in their finest attire, in attendance at the 2008 Texas Daily Newspaper Association annual conference awards dinner, held at The Westin Riverwalk Hotel in San Antonio, Texas.

Photograph of Cliff Clements (right) standing and chatting with another guest over drinks, dressed in their finest attire, in attendance at the 2008 Texas Daily Newspaper Association annual conference awards dinner, held at The Westin Riverwalk Hotel in San Antonio, Texas.

Photograph of Cliff Clements (right) standing and chatting with another guest over drinks, dressed in their finest attire, in attendance at the 2008 Texas Daily Newspaper Association annual conference awards dinner, held at The Westin Riverwalk Hotel in San Antonio, Texas.

Photograph of Dolph Tillotson and his wife Teri standing and chatting with another guests over drinks, dressed in their finest attire, in attendance at the 2008 Texas Daily Newspaper Association annual conference awards dinner, held at The Westin Riverwalk Hotel in San Antonio, Texas.