Correspondence issued by the Government Accountability Office with an abstract that begins "In connection with fulfilling our requirement to audit the financial statements of the U.S. government, we audited and reported on the Schedules of Federal Debt Managed by the Bureau of the Public Debt (BPD) for the fiscal years ended September 30, 2005 and 2004. As part of these audits, we performed a review of the general and application information security controls over key BPD financial systems. This report presents the issues identified during our fiscal year 2005 testing of the general and application information security controls that support key BPD automated financial systems relevant to BPD's Schedule of Federal Debt. This report also includes the results of our follow-up on the status of BPD's corrective actions to address recommendations that were contained in our prior years' audits and open as of September 30, 2004. We also assessed the general and application information security controls over key BPD financial systems that the Federal Reserve Banks (FRB) maintain and operate on behalf of BPD. We will issue a separate report to the Board of Governors of the Federal Reserve System on the results of such testing."

Testimony issued by the Government Accountability Office with an abstract that begins "About a dozen people are killed or injured in natural gas transmission pipeline incidents each year. In an effort to improve upon this safety record, the Pipeline Safety Improvement Act of 2002 requires that operators assess pipeline segments in about 20,000 miles of highly populated or frequented areas for safety risks, such as corrosion, welding defects, or incorrect operation. Half of these baseline assessments must be done by December 2007, and the remainder by December 2012. Operators must then repair or replace any defective pipelines, and reassess these pipeline segments for corrosion damage at least every 7 years. The Pipeline and Hazardous Materials Safety Administration (PHMSA) administers this program, called gas integrity management. This testimony is based on ongoing work for Congress, as required by the 2002 act. The testimony provides preliminary results on the safety effects of (1) PHMSA's gas integrity management program and (2) the requirement that operators reassess their natural gas pipelines at least every 7 years. It also discusses how PHMSA has acted to strengthen its enforcement program in response to recommendations GAO made in 2004. GAO expects to issue two reports this fall …

Testimony issued by the Government Accountability Office with an abstract that begins "The Department of Defense's (DOD) F-22A and Joint Strike Fighter (JSF) programs aim to replace many of the Department's aging tactical fighter aircraft--many of which have been in DOD's inventory for more than 20 years. Together, the F-22A and JSF programs represent a significant investment for DOD--currently estimated at almost $320 billion. GAO has reported on the poor outcomes in DOD's acquisitions of tactical aircraft and other major weapon systems. Cost and schedule overruns have diminished DOD's buying power and delayed the delivery of needed capabilities to the warfighter. Last year, GAO testified that weaknesses in the F-22A and JSF programs raised questions as to whether DOD's overarching tactical aircraft recapitalization goals were achievable. At the request of this Subcommittee, GAO is providing updated testimony on (1) the extent to which the current F-22A and JSF business cases are executable, (2) the current status of DOD's tactical aircraft recapitalization efforts, and (3) potential options for recapitalizing the air forces as DOD moves forward with its tactical aircraft recapitalization efforts."

Testimony issued by the Government Accountability Office with an abstract that begins "For many years, GAO has reported that ineffective information security is a widespread problem that has potentially devastating consequences. In its reports to Congress since 1997, GAO has identified information security as a governmentwide high-risk issue--most recently in January 2005. Concerned with accounts of attacks on commercial systems via the Internet and reports of significant weaknesses in federal computer systems that make them vulnerable to attack, Congress passed the Federal Information Security Management Act of 2002 (FISMA), which permanently authorized and strengthened the federal information security program, evaluation, and reporting requirements established for federal agencies. This testimony discusses the federal government's progress and challenges in implementing FISMA, as reported by the Office of Management and Budget (OMB), the agencies, and the Inspectors General (IGs), and actions needed to improve FISMA reporting and address underlying information security weaknesses."

Finite-difference weighted essentially non-oscillatory (WENO) simulations of the reshocked two-dimensional single-mode Richtmyer-Meshkov instability using third-, fifth- and ninth-order spatial flux reconstruction and uniform spatial grid resolutions corresponding to 128, 256 and 512 points per initial perturbation wavelength are presented. The dependence of the density, vorticity, simulated density Schlieren and baroclinic production fields, mixing layer width, circulation deposition, mixing profiles, chemical products and mixing fractions, energy spectra, statistics, probability distribution functions, effective turbulent kinetic energy and enstrophy production/dissipation rates, numerical Reynolds numbers, and effective numerical viscosity on the order and resolution is comprehensively investigated to long evolution times. The results are interpreted using the computed implicit numerical diffusion arising from the truncation errors in the characteristic projection-based WENO method. It is quantitatively shown that simulations with higher order and higher resolution have lower numerical dissipation. The sensitivity of the quantities considered to the order and resolution is further amplified following reshock, when the energy deposition on the evolving interface by the second shock-interface interaction induces the formation of small-scale structures. Simulations using lower orders of reconstruction and on coarser grids preserve large-scale structures and flow symmetry to late times, while simulations using higher orders of reconstruction and on finer grids exhibit …

We study electron clouds in high perveance beams (K = 8E-4) with a large tune depression of 0.2 (defined as the ratio of a single particle oscillation response to the applied focusing fields, with and without space charge). These 1 MeV, 180 mA, K+ beams have a beam potential of +2 kV when electron clouds are minimized. Simulation results are discussed in a companion paper [J-L. Vay, this Conference]. We have developed the first diagnostics that quantitatively measure the accumulation of electrons in a beam [1]. This, together with measurements of electron sources, will enable the electron particle balance to be measured, and electron-trapping efficiencies determined. We, along with colleagues from GSI and CERN, have also measured the scaling of gas desorption with beam energy and dE/dx [2]. Experiments where the heavy-ion beam is transported with solenoid magnetic fields, rather than with quadrupole magnetic or electrostatic fields, are being initiated. We will discuss initial results from experiments using electrode sets (in the middle and at the ends of magnets) to either expel or to trap electrons within the magnets. We observe electron oscillations in the last quadrupole magnet when we flood the beam with electrons from an end wall. These …

The growth and Cr(VI) reduction by Shewanella oneidensisMR-1 was examined using a mini-bioreactor system that independentlymonitors and controls pH, dissolved oxygen, and temperature for each ofits 24, 10-mL reactors. Independent monitoring and control of eachreactor in the cassette allows the exploration of a matrix ofenvironmental conditions known to influence S. oneidensis chromiumreduction. S. oneidensis MR-1 grew in minimal medium without amino acidor vitamin supplementation under aerobic conditions but required serineand glycine supplementation under anaerobic conditions. Growth wasinhibited by dissolved oxygen concentrations>80 percent. Lactatetransformation to acetate was enhanced by low concentration of dissolvedoxygen during the logarithmic growth phase. Between 11 and 35oC, thegrowth rate obeyed the Arrhenius reaction rate-temperature relationship,with a maximum growth rate occurring at 35oC. S. oneidensis MR-1 was ableto grow over a wide range of pH (6-9). At neutral pH and temperaturesranging from 30-35oC, S. oneidensis MR-1 reduced 100 mu M Cr(VI) toCr(III) within 20 minutes in the exponential growth phase, and the growthrate was not affected by the addition of chromate; it reduced chromateeven faster at temperatures between 35 and 39oC. At low temperatures(<25oC), acidic (pH<6.5), or alkaline (pH>8.5) conditions, 100mu M Cr(VI) strongly inhibited growth and chromate reduction. Themini-bioreactor system enabled the rapid determination of theseparameters …

In research as well as in clinical applications, fluorescence in situ hybridization (FISH) has gained increasing popularity as a highly sensitive technique to study cytogenetic changes. Today, hundreds of commercially available DNA probes serve the basic needs of the biomedical research community. Widespread applications, however, are often limited by the lack of appropriately labeled, specific nucleic acid probes. We describe two approaches for an expeditious preparation of chromosome-specific DNAs and the subsequent probe labeling with reporter molecules of choice. The described techniques allow the preparation of highly specific DNA repeat probes suitable for enumeration of chromosomes in interphase cell nuclei or tissue sections. In addition, there is no need for chromosome enrichment by flow cytometry and sorting or molecular cloning. Our PCR-based method uses either bacterial artificial chromosomes or human genomic DNA as templates with {alpha}-satellite-specific primers. Here we demonstrate the production of fluorochrome-labeled DNA repeat probes specific for human chromosomes 17 and 18 in just a few days without the need for highly specialized equipment and without the limitation to only a few fluorochrome labels.

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Document issued by the Office of the Attorney General of Texas in Austin, Texas, providing an interpretation of Texas law. It provides the opinion of the Texas Attorney General, Greg Abbott, regarding a legal question submitted for clarification; Whether section 533.035(e) of the Health and Safety Code, which provides that "a local mental health and mental retardation authority may serve as a provider of services only as a provider of last resort," applies to both mental health services and mental retardation services or only to mental retardation services (RQ-0392-GA)

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Fish and marine mammals are important resources in open ocean and nearshore coastal areas. Many laws and regulations guide the management of these resources by federal agencies. This report contains information on commercial and sport fisheries, aquaculture, and marine mammals and issues related to the 109th Congress.

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The temperature-dependent mass diffusion coefficient is computed using transition state theory. Ab initio supercell phonon calculations of the entire system provide the attempt frequency, the activation enthalpy, and the activation entropy as a function of temperature. Effects due to thermal lattice expansion are included and found to be significant. Numerical results for the case of hydrogen in nickel demonstrate a strong temperature dependence of the migration enthalpy and entropy. Trapping in local minima along the diffusion path has a pronounced effect especially at low temperatures. The computed diffusion coefficients with and without trapping bracket the available experimental values over the entire temperature range between 0 and 1400 K.

This report describes evaluation of collapse evolution for selected LLNL underground nuclear tests at the Nevada Test Site (NTS). The work is being done at the request of Bechtel Nevada and supports the Department of Energy National Nuclear Security Association Nevada Site Office Borehole Management Program (BMP). The primary objective of this program is to close (plug) weapons program legacy boreholes that are deemed no longer useful. Safety decisions must be made before a crater area, or potential crater area, can be reentered for any work. Our statements on cavity collapse and crater formation are input into their safety decisions. The BMP is an on-going program to address hundreds of boreholes at the NTS. Each year Bechtel Nevada establishes a list of holes to be addressed. They request the assistance of the Lawrence Livermore National Laboratory and Los Alamos National Laboratory Containment Programs to provide information related to the evolution of collapse history and make statements on completeness of collapse as relates to surface crater stability. These statements do not include the effects of erosion that may modify the collapse craters over time. They also do not address possible radiation dangers that may be present. Subject matter experts from the …

In 1930, Ernest Orlando Lawrence at the University of California at Berkeley invented the cyclotron. One of his students, M. Stanley Livingston, constructed a 13-cm diameter model that had all the features of early cyclotrons, accelerating protons to 80 keV using less than 1 kV on a semi-circular accelerating electrode, now called the ''dee''. Soon after, Lawrence constructed the first two-dee 27-Inch (69-cm) Cyclotron, which produced protons and deuterons of 4.8 MeV. In 1939, Lawrence constructed the 60-Inch (150-cm) Cyclotron, which accelerated deuterons to 19 MeV. Just before WWII, Lawrence designed a 184-inch cyclotron, but the war prevented the building of this machine. Immediately after the war ended, the Veksler-McMillan principle of phase stability was put forward, which enabled the transformation of conventional cyclotrons to successful synchrocyclotrons. When completed, the 184-Inch Synchrocyclotron produced 340-MeV protons. Following it, more modern synchrocyclotrons were built around the globe, and the synchrocyclotrons in Berkeley and Uppsala, together with the Harvard cyclotron, would perform pioneering work in treatment of human cancer using accelerated hadrons (protons and light ions). When the 184-Inch Synchrocyclotron was built, Lawrence asked Robert Wilson, one of his former graduate students, to look into the shielding requirements for of the new accelerator. …

Uranium and neptunium were used as reactive tracers in long-term laboratory desorption studies using saturated alluvium collected from south of Yucca Mountain, Nevada. The objective of these long-term experiments is to make detailed observations of the desorption behavior of uranium and neptunium to provide Yucca Mountain with technical bases for a more realistic and potentially less conservative approach to predicting the transport of adsorbing radionuclides in the saturated alluvium. This paper describes several long-term desorption experiments using a flow-through experimental method and groundwater and alluvium obtained from boreholes along a potential groundwater flow path from the proposed repository site. In the long term desorption experiments, the percentages of uranium and neptunium sorbed as a function of time after different durations of sorption was determined. In addition, the desorbed activity as a function of time was fit using a multi-site, multi-rate model to demonstrate that different desorption rate constants ranging over several orders of magnitude exist for the desorption of uranium from Yucca Mountain saturated alluvium. This information will be used to support the development of a conceptual model that ultimately results in effective K{sub d} values much larger than those currently in use for predicting radionuclide transport at Yucca Mountain.

Formation of cobalt sulfide hollow nanocrystals through amechanism similar to the Kirkendall Effect has been investigated indetail. It was found that performing the reaction at>120oC leads tofast formation of a single void ins ide each shell, whereas at roomtemperature multiple voids are formed within each shell, which can beattributed to strongly temperature-dependent diffusivities for vacancies.The void formation process is dominated by outward diffusion of cobaltcations; still, significant inward transport of sulfur anions can beinferred to occur as the final voids are smaller in diameter than theoriginal cobalt nanocrystals. Comparison of volume distributions forinitial and final nanostructures indicates excess apparent volume inshells implying significant porosity and/or a defective structure.Indirect evidence for shells to fracture during growth at lowertemperatures was observed in shell size statisticsand TEM of as-grownshells. An idealized model of the diffusional process imposes two minimalrequirements on material parameters for shell growth to be obtainablewithin a specific synthetic system.

Layered double hydroxides (LDHs) have shown great promise as anion getters. In this paper, we demonstrate that the sorption capability of a LDH for a specific oxyanion can be greatly increased by appropriately manipulating material composition and structure. A large set of LDH materials have been synthesized with various combinations of metal cations, interlayer anions, and the molar ratios of divalent cation M(II) to trivalent cation M(III). The synthesized materials have then been tested systematically for their sorption capabilities for pertechnetate (TcO{sub 4}{sup -}). It is discovered that for a given interlayer anion (either CO{sub 3}{sup 2-} or NO{sub 3}{sup -}) the Ni-Al LDH with a Ni/Al ratio of 3:1 exhibits the highest sorption capability among all the materials tested. The distribution coefficient (K{sub d}) is determined to be as high as 307 mL/g for Ni{sub 6}Al{sub 2}(0H){sub 16}CO{sub 3}nH{sub 2}O and 1390 mL/g for Ni{sub 6}Al{sub 2}(OH){sub 16}NO{sub 3}nH{sub 2}O at a pH of 8. The sorption of TcO{sub 4}{sup -} on M(II)-M(III)-CO{sub 3} LDHs is dominated by the edge sites of LDH layers and strongly correlated with the basal spacing d{sub 003} of the materials, which increases with the decreasing radii of both divalent and trivalent cations. The …

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