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Wnt signaling in triple-negative breast cancer
This review summarizes the involvement of dysregulated Wnt signaling in the progression of triple-negative breast cancer (TNBC) and TNBC stem cells, as well as the emerging therapies that are currently under investigation.
Date:
January 24, 2017
Creator:
Pohl, Sebastian Öther-Gee; Brook, N; Agostino, M.; Arfuso, Frank & Kumar, Alan Prem
Object Type:
Review
System:
The UNT Digital Library
Metabolic reprogramming underlies cavefish muscular endurance despite loss of muscle mass and contractility
Article discusses the Mexican cavefish Astyanax mexicanus, has lost moderate-to-vigorous activity following cave colonization, reaching basal swim speeds ~3.7-fold slower than their river-dwelling counterpart. Collectively, the authors reveal broad skeletal muscle changes following cave colonization, displaying an adaptive skeletal muscle phenotype reminiscent to mammalian disuse and high-fat models while simultaneously maintaining a unique capacity for sustained muscle contraction via enhanced glycogen metabolism.
Date:
January 24, 2023
Creator:
Olsen, Luke; Levy, Michaella; Medley, J. Kyle; Hassan, Huzaifa; Miller, Brandon; Alexander, Richard et al.
Object Type:
Article
System:
The UNT Digital Library
A Small Compound Targeting Prohibitin with Potential Interest for Cognitive Deficit Rescue in Aging mice and Tau Pathology Treatment
Article describes study analyzing the effects of a new purine derivative drug, PDD005, in attenuating mechanisms involved in the pathogenesis of neurodegenerative diseases, using both in vivo and in vitro models.
Date:
January 24, 2020
Creator:
Guyot, Anne-Cécile; Leuxe, Charlotte; Disdier, Clémence; Oumata, Nassima; Costa, Narciso; Le Roux, Gwenaëlle et al.
Object Type:
Article
System:
The UNT Digital Library