This report reviews aspects of experimental and clinical research performed in the investigation on the pathogenesis and recovery of bone marrow injury caused by total body irradiation.

The biological evaluation of the thermal neutron capture reaction of boron-10, B10 (n,α)Li7 + 2.786 MeV, has previously been studied, using different particles from the boron-10 thermal neutron capture reaction compared with 250 kvp x-rays has been reported as 1.05 for spleen-thymic weight reduction (1), as 1.5 to 2.0 for skin lesions in pigs (2), and 1.87 for skin lesions of the rabbit's ear (3). The significance of such a calculation is felt to be unreliable for the boron-10 reaction in animals because of the vagaries of dose determination resulting from irregular boron distribution, and by the presence of an adventitious irradiation from fast neutrons and capture gammas that is inadequately determined at present. Our present experiment attempts to circumvent the difficulties attendent to studies of the boron-10 reaction in animals by comparing the effect of this reaction on the proliferative capacity of HeLa cells with those produced with 250 kvp x-ray.

In these lectures we will discuss some examples of information about magnetic properties of solids which can be obtained by neutron scattering. We consider a scattering process in which a neutron with wave vector k and spin σ is incident upon a solid in state q>. (Here q stands for all of the quantum numbers which describe the state of the solid, such as spin and orbital electronic states, phonon numbers, etc.) After interacting with the solid, the neutron goes off with wave-vector k' and spin σ', leaving the solid in state q'>. In performing an experiment of this sort one does not usually observe the initial and final spin states of the neutron or the initial and final states of the solid. We must then sum over all possible final states and average over all initial states.

The driving force for liquid metal corrosion is the equilization of chemical potential for dissolution of all solid surfaces in contact with the liquid. In any practical system, this is an impossible goal; therefore, one observes several mass transfer processes.

We consider the kinetic isotope effect in three center reactions of the type of A+BC→AB+C. Such model calculations are a good approximation to primary hydrogen isotope effects. For abstraction or transfer reactions, B becomes H, D, or T. The dynamics of the three storm system are calculated for a general quadratic potential, with the assumption that the potential energy is constant along the reaction coordinate (flat top barrier). This model system can be calculated in detail and serves to illustrate the relationship between kinetic isotope effect and chemical bonding in the transition state. The statistical mechanical part of the calculation can be carried out exactly within the framework transition state theory or in any one of a number of approximations. The γ bar method gives particularly good insight into the chemistry of the problem with a minimum of arithmetic.

Optical absorption and photoconductivity measurements have been made on single crystals of pure synthetic rutile (TiO2). Reactor irradiations at 70°C totaling 4.8 x 10 18 nvt fast and 1.69 x10 19 nvt slow did not produce any discernible optical absorption bands; however, the transmission decreased 5 percent at all wavelengths. Reactor irradiation induced a [illegible] five photoconduction peaks in the wavelength range 4200 to 14,000 A. In addition the photopeak at 4065 A (3.05 eV) was enhanced and there were drastic changes in the dependence of photocurrent with light intensity. Gamma-ray irradiations as large as 10 9 r do not change the conduction properties. The photocurrent is proportional to a power of the light intensity; the power range from 0.65 to 1.24, for the crystals described in this work. The photocurrent vs. voltage dependence is more complex.

The present core of the Brookhaven Graphite Reactor consists of some 4900 highly enriched uranium fuel loaded in 615 horizontal fuel channels passing through a 25 foot cube of graphite moderator and reflector. The core is divided into two halves (north and south) by an 8 cm. wide vertical gap in the center of the graphite. The cooling air enters the reactor through inlet filters, at the rate of 270,000 CFM, passes into the central gap and flows bi-directionally through the north and south halves of the core. It then enters the collecting plenums and flows into the north and south ducts. The air is first monitored by the north and south exit air monitors located within the pile building. These are moving filter tape monitors with beta scintillation detectors. They are essentially operational monitors and are maintained by reactor operations. They are essentially operational monitors and are maintained by a reactor operations. The air then passes through the exit air filters, heat exchanger, venturi and on to the fan house where the north and south ducts join. After the fan house the air is monitored by Argon-41 by a Kanne ion chamber syste.

Boron-10 has a high thermal neutron capture cross section (3880 barns). Following neutron capture, the subsequent nuclear disintegration produces an alpha particle and a lithium-7 nucleus with the release of an average of 2.34 MeV for the particle irradiation, and in 93% of the reactions there is also the emission of an 0.48 MeV gamma ray: [equation not transcribed]. The kinetic energy is divided between the lithium-7 nucleus and the alpha particle giving the equal and opposite momentums with a range in tissue of about 8-14μ or approximately 1 cell diameter (1). This fact and the reported favorable partition of boron between tumor and the normal brain suggested a possible therapeutic usefulness which has been investigated clinically. The object of our study is to document the biological effects of the B10 (n,α) Li7 reaction on the brain of dogs injected with boron-10 30 minutes prior to irradiation with thermal neutrons. For this, we felt it desirable to estimate a dose for the boron-10 reaction which if exceeded, produces destruction of normal tissue. This dose could then be a reference dose to be utilized as a maximal limit for the irradiation of normal tissue. We have assured that the largest fluence …

There is but little known about the thermal process involving the dynamics and thermodynamics of the cycling liquid H2 in the chamber and those of the H2 fluid flow in the cooling coil as well as the geometrical characteristics of the chamber body. This the physical equations governing this process are involving so many variables that this analysis becomes rather complex even if simplifying assumptions are made. To those difficulties is added the ignorance even of an approximative expression for some physical quantities such as film heat transfer coefficients entering as major parameters the process equation.

The purpose of this report is to determine the amount of refrigeration capacity required to cool down the 80" bubble chamber from ambient temperature to liquid hydrogen temperature.

The undercarriage system is required for translating, rotating, and lifting the 450 ton magnet and bubble chamber assemblies so that it can be accurately positioned in the experimental proton beam of the synchrotron. The system must make provision for the two magnet sections to be separated for the purpose of adjustment and maintenance of internal components.

The following general description of the theory and operation of a bubble chamber is presented so that firms who are interested in fabricating components for the Brookhaven 80" chamber will have a better understanding of the design parameters associated with it. This understanding, coupled with the fabricator's knowledge of manufacturing techniques, should enable the fabricators to suggest solutions to manufacturing problems consistent with requirements for chamber operation. In an effort to increase knowledge of fundamental nuclear particles and their interactions at high energies, various types of detecting equipment have been developed. One of these detectors recently developed is the bubble chamber. While there are variations as to liquids used, expansion techniques, means of illumination, etc. the basic concepts upon which all bubble chambers operate are similar. Therefore, it will be sufficient in this report to consider only one specific type, that is a chamber using liquid hydrogen

Six useful characteristics of radioisotopes and advantages which may be taken of them are cited briefly, with examples. A survey of unusual or less frequently used production techniques for radioisotope production are presented including (n,p) reactions and secondary reactions such as (t,n) and (t,p) induced by thermal neutron, various techniques for obtaining useful fluxes of fast neutrons with which to effect other reactions, recoil techniques including classic Szilard-Chalmers reactions, use of charged wires to collect short-lived daughters of gaseous parents, parent-daughter milking system, parasitic irradiations, the possible use of circulating "loops" in reactor withy which to utilize the radiation from ultra-short lived radioisotopes such as Ag-110, In-114, In-116, Dy-165m etc., and stable tracers. A summary of the current status of Brookhaven's Reactor-Produced "Special" Radioisotopes is also presented..

Human iron metabolism has been extensively studied in the past twenty-five years with the radioisotopes iron⁵⁵ and iron⁵⁹. Before the availability of the whole body counter, however, iron absorption studies were performed by the indirect methods of fecal assay of unabsorbed radioiron, and estimation of red cell incorporation of absorbed tracer. The few long-term excretion studies performed required numerous assumptions, since human iron excretion was less well understood. Whole body counting provides a simple and accurate method of measuring the total body retention of administrative tracer iron⁵⁹, thus making absorption and subsequent excretion determinations possible with a single radioiron study. The energetic gamma emissions of iron⁵⁹ permit ready external detection with small quantities of isotope, Normal radioiron distribution is uniform throughout the circulating red cell mass and thus minimize geometry influences on the counting efficiency, 0nly the 45.1 day half-life of iron⁵⁹ limits long term iron turnover studies. Measurements of iron⁵⁹ absorption and long-term body turnover have been under way at Brookhaven National Laboratory for over two years. The present paper outlines some of the results of these studies, and discusses some implications of the method.

A brief overview of a study on the effect of 5-fluoroucil (FU) on chloroplast formation in Euglena,

The G-values for the formation of H₂ and CH₄ in the Co60 gamma radiolysis of the xylene isomers and ethylbenzene were compared. The presence of iodine does not affect GH2, but reduces GCH4 a limiting value. For p-xylene, GH2 and the unscavengeable CH₄ yield are independent of temperature from 20 to 110 deg C, whereas the total CH₄ yield increases six-fold over this range. The H₂ and CH₄ yields are greatly reduced in the solid state, and in the liquids state benzene shows a protective effect on the yields of both gases. The formation of CH₄ and C₂ -hydrocarbons was compared with the C6 -and C7 - products for p- xylene and ethylbenzene, and isomerization is shown to occur to a negligible extent. The production of high-molecular-weight products was measured for the xylenes, and is independent of dose rate and temperature for liquid p-xylene, but is decreased in the solid state. The results are qualitatively consistent with the reactions of radicals and excited molecules.

A summary of the dynamic behavior of the proton bunches in the Brookhaven Alternating Gradient Synchrotron (AGS) has been given previously. In these reports, the usual linearization of the differential equations involved has been made and the theory was restricted to well bunched beams. The linearized approach is no longer valid at transition where the actual phase angle of the bunch can differ appreciably for a short time from the stable phase angle Φ₀. In this report the non-linearity of the differential equations for phase oscillations will no longer be neglected. At transition the beam is slow enough so that the electronics of the bootstrap system can be considered as being ideal and the radius servo loop can be characterized by one time constant. Under these assumptions the analysis can be carried out in a two-dimensional phase plane. The essential new result will be the short existence of a stable equilibrium point for the bunch motion not coinciding with Φ₀. The results here derived have been tested experimentally and at least a qualitative agreement was found. However, the conclusions are no more valid if debunching takes place since we have still neglected the finite bunch width.

Technique used in deriving values of the linac ball tuner settings to produce various fields is discussed briefly, and tables showing ball tuner change numbers and values used in making up the ball tuner change numbers are given.

Use of the Smith chart in studying stub tuners is demonstrated. Several properties of the tuners are shown, and charts for various wave length spacings, tuning trajectories, and admittances are included.

Description of a computer program which optimizes the locations and strengths of magnets for experimental beams at the Brookhaven AGS written for the IBM 7090 computer. Layout, method, and routines are given particular attention, and representative data cards are shown.

The efficiency of multiple traversal targets is defined as the probability that a proton dies by making a nuclear collision in the target rather than by hitting the limit of the synchrotron aperture. The efficiencies of Be, Al, Cu, and Pb targets are shown for 15 and 30-Bev protons in the Brooknaven AGS. Beryllium was found to be the most efficient. (M.C.G.)

This is a preliminary report on the magnetic measurements taken to date on the AGS experimental magnets. It mainly summarizes the results which were necessary for the setting up of the proton separated beam in August 1961. A few curves on information obtained since then are included. When the study is finished, a complete report on all phases of the work, including the methods used, will be forthcoming.

A tranistorized d.c. coupled amplifier having very good gain stability, as well as very low drift of the output d.c. level, has been designed. Low frequency input signals with an amplitude of .04 to 2 volts peak-to-peak, approximately, coming from a low impedance source (voice soil of a speaker system) are amplified to an approximate peak-to-peak amplitude of 4 volts. The output is intended to drive a load of the order of 100 kohm.

The analyzer can be operated either internally or externally. The 10 ma germanium discriminator is quiescently biased to 8.5 ma in its low-voltage state. An input signal current of 3.5 ma or more triggers it to its high voltage state. This triggers the oscillator. The oscillator signal is buffered and mixed in the bridge modulator with the reference radiofrequency signal from the cyclotron. The low-frequency beat note from the bridge modulator is squared up and passed to the beat zero univibrator which generates 0.7 mu sec signals each time the beat note passes through zero from positive to negative. The trailing edge of the beat zero univibrator is employed to terminate the time-of-flight measurement and to control the servo measurement. Drawings are included. (M.C.G.)