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GAW20: methods and strategies for the new frontiers of epigenetics and pharmacogenomics (open access)

GAW20: methods and strategies for the new frontiers of epigenetics and pharmacogenomics

Article presents an overview of the data sets and the contributions analyzing data related to human lipid-related phenotypes, DNA methylation, and single-nucleotide markers in a study involving a pharmaceutical intervention.
Date: September 17, 2018
Creator: Tintle, Nathan L.; Fardo, David W.; de Andrade, Mariza; Aslibekyan, Stella; Bailey, Julia N.; Bermejo, Justo Lorenzo et al.
Object Type: Article
System: The UNT Digital Library
Methods and results from the genome-wide association group at GAW20 (open access)

Methods and results from the genome-wide association group at GAW20

This article reports on promising statistical approaches and findings of the members of the Genome-wide Association Study group applied on real and simulated data which encompass the current topics of epigenetic and pharmacogenomics.
Date: September 17, 2018
Creator: Wang, Xuexia; Boekstegers, Felix & Brinster, Regina
Object Type: Article
System: The UNT Digital Library
Methods and Results From the Genome-Wide Association Group at Genetic Analysis Workshop 20 (open access)

Methods and Results From the Genome-Wide Association Group at Genetic Analysis Workshop 20

This article summarizes the contributions from the Genome-wide Association Study group (GWAS group) of the GAW20. The GWAS group contributions focused on topics such as association tests, phenotype imputation, and application of empirical kinships. This summary article reports on promising statistical approaches and findings of the members of the GWAS group applied on real and simulated data which encompass the current topics of epigenetic and pharmacogenomics.
Date: September 17, 2018
Creator: Wang, Xuexia; Boekstegers, Felix & Brinster, Regina
Object Type: Article
System: The UNT Digital Library
Methods to evaluate rare variants gene-age interaction for triglycerides (open access)

Methods to evaluate rare variants gene-age interaction for triglycerides

This article discusses the development of two statistical methods to test the gene environment interaction effect of rare variants.
Date: September 17, 2018
Creator: Huayang Gao, Tony; Zhang, Jianjun; Medina Miguelangel, Diaz & Wang, Xuexia
Object Type: Article
System: The UNT Digital Library
Parametric nondifferentiable multiobjective fractional programming under (b;Ψ; Φ; ρ)-univexity (open access)

Parametric nondifferentiable multiobjective fractional programming under (b;Ψ; Φ; ρ)-univexity

This article is concerned with optimality conditions and duality results for nondifferentiable multi-objective fractional programming problems.
Date: September 27, 2018
Creator: Antczak, Tadeusz & Verma, Ram U.
Object Type: Article
System: The UNT Digital Library
A random walk version of Robbins' problem: small horizon (open access)

A random walk version of Robbins' problem: small horizon

This article considers an analogous problem in which the observed random variables are the steps of a symmetric random walk. Assuming continuously distributed step sizes, it describes the optimal stopping rules for the cases n = 2 and n = 3 in two versions of the problem: a "full information" version in which the actual steps of the random walk are disclosed to the decision maker; and a "partial information" version in which only the relative ranks of the positions taken by the random walk are observed. When n = 3, the optimal rule and expected rank depend on the distribution of the step sizes. The authors give sharp bounds for the optimal expected rank in the partial information version, and fairly sharp bounds in the full information version.
Date: November 17, 2018
Creator: Allaart, Pieter C. & Allen, Andrew
Object Type: Article
System: The UNT Digital Library
Local and Systemic Metabolic Responses during Light-Induced Rapid Systemic Signaling (open access)

Local and Systemic Metabolic Responses during Light-Induced Rapid Systemic Signaling

This article reports that local application of light stress to one rosette leaf of bolting Arabidopsis (Arabidopsis thaliana) plants resulted in a metabolic response that encompassed local, systemic and transport tissues, demonstrating a high degree of physical and metabolic continuity between different tissues throughout the plant.
Date: December 2018
Creator: Choudhury, Feroza K.; Devireddy, Amith R.; Azad, Rajeev K.; Shulaev, Vladimir & Mittler, Ron
Object Type: Article
System: The UNT Digital Library
Identification and characterization of a core set of ROS wave‐associated transcripts involved in the systemic acquired acclimation response of Arabidopsis to excess light (open access)

Identification and characterization of a core set of ROS wave‐associated transcripts involved in the systemic acquired acclimation response of Arabidopsis to excess light

Article reveal that the systemic transcriptomic response of plants to excess light stress is extensive in the context of systemic acquired acclimation and involves an early (2 min) and transient stage of transcript expression that includes thousands of genes.
Date: December 6, 2018
Creator: Zandalinas, Sara I.; Sengupta, Soham; Burks, David; Azad, Rajeev K. & Mittler, Ron
Object Type: Article
System: The UNT Digital Library
Foias Numbers (open access)

Foias Numbers

This article identifies the principal features in Foias’ original proof and streamlines them into a general result. The result gives further evidence to the observation that the connection between the sequence with initial seed the Foias constant and the Prime Number Theorem must be fortuitous.
Date: December 30, 2018
Creator: Anghel, Nicolae
Object Type: Article
System: The UNT Digital Library
Topological mixing properties of rank‐one subshifts (open access)

Topological mixing properties of rank‐one subshifts

Article describes study examining the topological mixing properties and the maximal equicontinuous factor of rank‐one subshifts as topological dynamical systems
Date: February 7, 2019
Creator: Gao, Su & Ziegler, Caleb
Object Type: Article
System: The UNT Digital Library
Universality in a one-dimensional three-body system (open access)

Universality in a one-dimensional three-body system

Article studying a heavy-heavy-light three-body system confined to one space dimension.
Date: July 24, 2019
Creator: Happ, Lucas; Zimmermann, Matthias; Betelu, Santiago I.; Schleich, Wolfgang P. & Efremov, Maxim A.
Object Type: Article
System: The UNT Digital Library
A gene based approach to test genetic association based on an optimally weighted combination of multiple traits (open access)

A gene based approach to test genetic association based on an optimally weighted combination of multiple traits

In this article, the authors propose a statistical method by Testing an Optimally Weighted Combination of Multiple traits (TOW-CM) to test the association between multiple traits and multiple variants in a genomic region (a gene or pathway). They investigate the performance of the proposed method through extensive simulation studies. Their simulation studies show that the proposed method has correct type I error rates and is either the most powerful test or comparable with the most powerful tests. Additionally, they illustrate the usefulness of TOW-CM based on a COPDGene study.
Date: August 9, 2019
Creator: Zhang, Jianjun; Sha, Qiuying; Liu, Guanfu & Wang, Xuexia
Object Type: Article
System: The UNT Digital Library
Existence of Infinitely Many Solutions for Singular Semilinear Problems on Exterior Domains (open access)

Existence of Infinitely Many Solutions for Singular Semilinear Problems on Exterior Domains

Article proving the existence of infinitely many radial solutions of ∆𝓊+𝐾(𝓇) ƒ (𝓊) = 0 on the exterior of the ball of radius R > 0, BR, centered at the origin in ℝᴺ with u = 0 on ∂BR and lim/r→∞ 𝓊(𝓇) = 0 where N > 2, f is odd with f < 0 on (0, β), f > 0 on (β, ∞), f is superlinear for large u, ƒ(𝓊) ∼ −1/(|𝓊|𝘲⁻¹𝓊) with 0 < q < 1 for small u, and 0 < 𝐾(𝓇) ≤ 𝐾₁/r∝ with 𝑁 + q(𝑁 − 2) < ∝ < 2(𝑁− 1) for large r.
Date: March 9, 2018
Creator: Iaia, Joseph A.
Object Type: Article
System: The UNT Digital Library
IslandCafe: Compositional Anomaly and Feature Enrichment Assessment for Delineation of Genomic Islands (open access)

IslandCafe: Compositional Anomaly and Feature Enrichment Assessment for Delineation of Genomic Islands

Article discusses IslandCafe, a proposed method for genomic island detection.
Date: October 1, 2019
Creator: Jani, Mehul & Azad, Rajeev K.
Object Type: Article
System: The UNT Digital Library
The spectrum of two interesting stochastic matrices (open access)

The spectrum of two interesting stochastic matrices

Article discusses the determination of the spectrum of two interesting stochastic matrices appearing in an engineering paper.
Date: January 21, 2020
Creator: Anghel, Nicolae
Object Type: Article
System: The UNT Digital Library
Testing gene-environment interactions for rare and/or common variants in sequencing association studies (open access)

Testing gene-environment interactions for rare and/or common variants in sequencing association studies

Article describes study in which novel approaches to test the effects of gene-environment (GE) interactions of rare and/or common risk, and/or protective variants in sequencing association studies were developed.
Date: March 10, 2020
Creator: Zhao, Zihan; Zhang, Jianjun; Sha, Qiuying & Hao, Han
Object Type: Article
System: The UNT Digital Library
The genome of jojoba (Simmondsia chinensis): A taxonomically isolated species that directs wax ester accumulation in its seeds (open access)

The genome of jojoba (Simmondsia chinensis): A taxonomically isolated species that directs wax ester accumulation in its seeds

Article describes the high-quality, 887-Mb genome of jojoba assembled into 26 chromosomes with 23,490 protein-coding genes.
Date: March 11, 2020
Creator: Sturtevant, Drew; Lu, Shaoping; Zhou, Zhi-Wei; Shen, Yin; Wang, Shuo; Song, Jia-Ming et al.
Object Type: Article
System: The UNT Digital Library
Existence of solutions for semilinear problems on exterior domains (open access)

Existence of solutions for semilinear problems on exterior domains

Article proves the existence of an infinite number of radial solutions to ∆u+K(r)f(u) = 0 on ℝᶰ such that limᵣ →∞ u(r) = 0 with prescribed number of zeros on the exterior of the ball of radius R > 0 where f is odd with f < 0 on (0, β), f > 0 on (β, ∞) with f superlinear for large u, and K(r) ∼ r ⁻ᵅ with α > 2(N − 1).
Date: April 15, 2020
Creator: Iaia, Joseph A.
Object Type: Article
System: The UNT Digital Library
TS: A powerful truncated test to detect novel disease associated genes using publicly available gWAS summary data (open access)

TS: A powerful truncated test to detect novel disease associated genes using publicly available gWAS summary data

This article proposes a new truncated statistic method (TS) by utilizing a truncated method to find the genes that have a true contribution to the genetic association. The proposed truncated statistic outperforms existing methods. It can be employed to detect novel traits associated genes using GWAS summary data.
Date: May 4, 2020
Creator: Zhang, Jianjun; Guo, Xuan; Gonzales, Samantha; Yang, Jingjing & Wang, Xuexia
Object Type: Article
System: The UNT Digital Library
On the standard L-function for GSp2n × GL1 and algebraicity of symmetric fourth L-values for GL2 (open access)

On the standard L-function for GSp2n × GL1 and algebraicity of symmetric fourth L-values for GL2

This article proves an explicit integral representation—involving the pullback of a suitable Siegel Eisenstein series—for the twisted standard L-function associated to a holomorphic vector-valued Siegel cusp form of degree n and arbitrary level.
Date: May 6, 2020
Creator: Pitale, Ameya; Saha, Abhishek & Schmidt, Ralf
Object Type: Article
System: The UNT Digital Library
Systemic signaling during abiotic stress combination in plants (open access)

Systemic signaling during abiotic stress combination in plants

Article reveals that plants can integrate different local and systemic signals generated during conditions of stress combination. Furthermore, results show that the specific part at which plants sense the two co-occurring stresses makes a significant difference in how fast and efficient they acclimate.
Date: May 29, 2020
Creator: Sengupta, Soham; Azad, Rajeev K.; Zandalinas, Sara I.; Fichman, Yosef; Devireddy, Amith R. & Mittler, Ron
Object Type: Article
System: The UNT Digital Library
Nematic order on a deformable vesicle with anchoring effects (open access)

Nematic order on a deformable vesicle with anchoring effects

This article proposes a new model to represent a vesicle membrane with internal nematic order whose equilibrium states depend on the competition between the bending, elastic and anchoring energies.
Date: July 7, 2020
Creator: Tierra Chica, Giordano; Guillén-González, Francisco & Rodríguez-Bellido, María Ángeles
Object Type: Article
System: The UNT Digital Library
Lipophilic signals lead to organ-specific gene expression changes in Arabidopsis seedlings (open access)

Lipophilic signals lead to organ-specific gene expression changes in Arabidopsis seedlings

Article presents a study where whole transcriptome sequencing (RNA-seq) and differential expression analysis were used to identify early (1–3 hr) transcriptional changes induced by the exogenous treatment of NAE 18:2 and NAE 18:3 in cotyledons, roots, and seedlings.
Date: July 15, 2020
Creator: Cannon, Ashley E.; Yan, Chengshi; Burks, David J.; Rao, Xiaolan; Azad, Rajeev K. & Chapman, Kent Dean
Object Type: Article
System: The UNT Digital Library
MYB30 Orchestrates Systemic Reactive Oxygen Signaling and Plant Acclimation (open access)

MYB30 Orchestrates Systemic Reactive Oxygen Signaling and Plant Acclimation

This article explores the relationship among MYB30, the ROS wave, and systemic acclimation in Arabidopsis by determining the SAA response to HL stress of MYB30 mutants and wild-type plants.
Date: July 22, 2020
Creator: Fichman, Yosef; Zandalinas, Sara I.; Sengupta, Soham; Burks, David J.; Meyers, Ronald J., Jr.; Azad, Rajeev K. et al.
Object Type: Article
System: The UNT Digital Library