Computational modeling is of fundamental significance in mapping possible disease spread, and designing strategies for its mitigation. Conventional contact networks implement the simulation of interactions as random occurrences, presenting public health bodies with a difficult trade off between a realistic model granularity and robust design of intervention strategies. Recently, researchers have been investigating the use of agent-based models (ABMs) to embrace the complexity of real world interactions. At the same time, theoretical approaches provide epidemiologists with general optimization models in which demographics are intrinsically simplified. The emerging study of affiliation networks and co-affiliation networks provide an alternative to such trade off. Co-affiliation networks maintain the realism innate to ABMs while reducing the complexity of contact networks into distinctively smaller k-partite graphs, were each partition represent a dimension of the social model. This dissertation studies the optimization of intervention strategies for infectious diseases, mainly distributed in school systems. First, concepts of synthetic populations and affiliation networks are extended to propose a modified algorithm for the synthetic reconstruction of populations. Second, the definition of multi-coaffiliation networks is presented as the main social model in which risk is quantified and evaluated, thereby obtaining vulnerability indications for each school in the system. Finally, maximization …

One in seven people in the world use online social networking for a variety of purposes -- to keep in touch with friends and family, to share special occasions, to broadcast announcements, and more. The majority of society has been bought into this new era of communication technology, which allows everyone on the internet to share information with friends. Since social networking has rapidly become a main form of communication, holes in privacy have become apparent. It has come to the point that the whole concept of sharing information requires restructuring. No longer are online social networks simply technology available for a niche market; they are in use by all of society. Thus it is important to not forget that a sense of privacy is inherent as an evolutionary by-product of social intelligence. In any context of society, privacy needs to be a part of the system in order to help users protect themselves from others. This dissertation attempts to address the lack of privacy management in online social networks by designing models which understand the social science behind how we form social groups and share information with each other. Social relationship strength was modeled using activity patterns, vocabulary usage, …

The spread of infectious diseases has been a public concern throughout human history. Historic recorded data has reported the severity of infectious disease epidemics in different ages. Ancient Greek physician Hippocrates was the first to analyze the correlation between diseases and their environment. Nowadays, health authorities are in charge of planning strategies that guarantee the welfare of citizens. The simulation of contagion scenarios contributes to the understanding of the epidemic behavior of diseases. Computational models facilitate the study of epidemics by integrating disease and population data to the simulation. The use of detailed demographic and geographic characteristics allows researchers to construct complex models that better resemble reality and the integration of these attributes permits us to understand the rules of interaction. The interaction of individuals with similar characteristics forms synthetic structures that depict clusters of interaction. The synthetic environments facilitate the study of the spread of infectious diseases in diverse scenarios. The characteristics of the population and the disease concurrently affect the local and global epidemic progression. Every cluster’ epidemic behavior constitutes the global epidemic for a clustered population. By understanding the correlation between structured populations and the spread of a disease, current dissertation research makes possible to identify risk …

In many real-world applications, it is common to have uneven number of examples among multiple classes. The data imbalance, however, usually complicates the learning process, especially for the minority classes, and results in deteriorated performance. Boosting methods were proposed to handle the imbalance problem. These methods need elongated training time and require diversity among the classifiers of the ensemble to achieve improved performance. Additionally, extending the boosting method to handle multi-class data sets is not straightforward. Examples of applications that suffer from imbalanced multi-class data can be found in face recognition, where tens of classes exist, and in capsule endoscopy, which suffers massive imbalance between the classes. This dissertation introduces RegBoost, a new boosting framework to address the imbalanced, multi-class problems. This method applies a weighted stratified sampling technique and incorporates a regularization term that accommodates multi-class data sets and automatically determines the error bound of each base classifier. The regularization parameter penalizes the classifier when it misclassifies instances that were correctly classified in the previous iteration. The parameter additionally reduces the bias towards majority classes. Experiments are conducted using 12 diverse data sets with moderate to high imbalance ratios. The results demonstrate superior performance of the proposed method compared …

Software applications’ performance is hindered by a variety of factors, but most notably by the well-known CPU-memory speed gap (often known as the memory wall). This results in the CPU sitting idle waiting for data to be brought from memory to processor caches. The addressing used by caches cause non-uniform accesses to various cache sets. The non-uniformity is due to several reasons, including how different objects are accessed by the code and how the data objects are located in memory. Memory allocators determine where dynamically created objects are placed, thus defining addresses and their mapping to cache locations. It is important to evaluate how different allocators behave with respect to the localities of the created objects. Most allocators use a single attribute, the size, of an object in making allocation decisions. Additional attributes such as the placement with respect to other objects, or specific cache area may lead to better use of cache memories. In this dissertation, we proposed and implemented a framework that allows for the development and evaluation of new memory allocation techniques. At the root of the framework is a memory tracing tool called Gleipnir, which provides very detailed information about every memory access, and relates it …

In recent years there has been growing interest in limitless realism in computer graphics applications. Among those, my foremost concentration falls into the complex physical simulations and modeling with diverse applications for the gaming industry. Different simulations have been virtually successful by replicating the details of physical process. As a result, some were strong enough to lure the user into believable virtual worlds that could destroy any sense of attendance. In this research, I focus on fire simulations and its deformation process towards various virtual objects. In most game engines model loading takes place at the beginning of the game or when the game is transitioning between levels. Game models are stored in large data structures. Since changing or adjusting a large data structure while the game is proceeding may adversely affect the performance of the game. Therefore, developers may choose to avoid procedural simulations to save resources and avoid interruptions on performance. I introduce a process to implement a real-time model deformation while maintaining performance. It is a challenging task to achieve high quality simulation while utilizing minimum resources to represent multiple events in timely manner. Especially in video games, this overwhelming criterion would be robust enough to sustain …

The increasingly popular cloud-computing paradigm provides on-demand access to computing and storage with the appearance of unlimited resources. Users are given access to a variety of data and software utilities to manage their work. Users rent virtual resources and pay for only what they use. In spite of the many benefits that cloud computing promises, the lack of dependability in shared virtualized infrastructures is a major obstacle for its wider adoption, especially for mission-critical applications. Virtualization and multi-tenancy increase system complexity and dynamicity. They introduce new sources of failure degrading the dependability of cloud computing systems. To assure cloud dependability, in my dissertation research, I develop autonomic failure identification and diagnosis techniques that are crucial for understanding emergent, cloud-wide phenomena and self-managing resource burdens for cloud availability and productivity enhancement. We study the runtime cloud performance data collected from a cloud test-bed and by using traces from production cloud systems. We define cloud signatures including those metrics that are most relevant to failure instances. We exploit profiled cloud performance data in both time and frequency domain to identify anomalous cloud behaviors and leverage cloud metric subspace analysis to automate the diagnosis of observed failures. We implement a prototype of the …

The promise of service oriented computing, and the availability of Web services promote the delivery and creation of new services based on existing services, in order to meet new demands and new markets. As Web and internet based services move into Clouds, inter-dependency of services and their complexity will increase substantially. There are standards and frameworks for specifying and composing Web Services based on functional properties. However, mechanisms to individually address non-functional properties of services and their compositions have not been well established. Furthermore, the Cloud ontology depicts service layers from a high-level, such as Application and Software, to a low-level, such as Infrastructure and Platform. Each component that resides in one layer can be useful to another layer as a service. It hints at the amount of complexity resulting from not only horizontal but also vertical integrations in building and deploying a composite service. To meet the requirements and facilitate using Web services, we first propose a WSDL extension to permit specification of non-functional or Quality of Service (QoS) properties. On top of the foundation, the QoS-aware framework is established to adapt publicly available tools for Web services, augmented by ontology management tools, along with tools for performance modeling …

Ambiguity is inherent to human language. In particular, word sense ambiguity is prevalent in all natural languages, with a large number of the words in any given language carrying more than one meaning. Word sense disambiguation is the task of automatically assigning the most appropriate meaning to a polysemous word within a given context. Generally the problem of resolving ambiguity in literature has revolved around the famous quote “you shall know the meaning of the word by the company it keeps.” In this thesis, we investigate the role of context for resolving ambiguity through three different approaches. Instead of using a predefined monolingual sense inventory such as WordNet, we use a language-independent framework where the word senses and sense-tagged data are derived automatically from Wikipedia. Using Wikipedia as a source of sense-annotations provides the much needed solution for knowledge acquisition bottleneck. In order to evaluate the viability of Wikipedia based sense-annotations, we cast the task of disambiguating polysemous nouns as a monolingual classification task and experimented on lexical samples from four different languages (viz. English, German, Italian and Spanish). The experiments confirm that the Wikipedia based sense annotations are reliable and can be used to construct accurate monolingual sense classifiers. …

Emergency Medical Dispatch Protocols are guidelines that a 9-1-1 dispatcher uses to evaluate the nature of emergency, resources to send and the nature of help provided to the 9-1-1 caller. The current Dispatch Protocols are based on voice only call. But the Next Generation 9-1-1 (NG9-1-1) architecture will allow multimedia emergency calls. In this thesis I analyze and model the Emergency Medical Dispatch Protocols for NG9-1-1 architecture. I have identified various technical aspects to improve the NG9-1-1 Dispatch Protocols. The devices (smartphone) at the caller end have advanced to a point where they can be used to send and receive video, pictures and text. There are sensors embedded in them that can be used for initial diagnosis of the injured person. There is a need to improve the human computer (smartphone) interface to take advantage of technology so that callers can easily make use of various features available to them. The dispatchers at the 9-1-1 call center can make use of these new protocols to improve the quality and the response time. They will have capability of multiple media streams to interact with the caller and the first responders.The specific contributions in this thesis include developing applications that use smartphone …

As video capturing devices become more ubiquitous from surveillance cameras to smart phones, the demand of automated video analysis is increasing as never before. One obstacle in this process is to efficiently locate where a human operator’s attention should be, and another is to determine the specific types of activities or actions without ambiguity. It is the special interest of this dissertation to locate spatial and temporal regions of interest in videos and to develop a better action representation for video-based activity analysis. This dissertation follows the scheme of “locating then recognizing” activities of interest in videos, i.e., locations of potentially interesting activities are estimated before performing in-depth analysis. Theoretical properties of regions of interest in videos are first exploited, based on which a unifying framework is proposed to locate both spatial and temporal regions of interest with the same settings of parameters. The approach estimates the distribution of motion based on 3D structure tensors, and locates regions of interest according to persistent occurrences of low probability. Two contributions are further made to better represent the actions. The first is to construct a unifying model of spatio-temporal relationships between reusable mid-level actions which bridge low-level pixels and high-level activities. Dense …

Segmentation, recognition and 3D reconstruction of objects have been cutting-edge research topics, which have many applications ranging from environmental and medical to geographical applications as well as intelligent transportation. In this dissertation, I focus on the study of segmentation, recognition and 3D reconstruction of objects using LiDAR data/MRI. Three main works are that (I). Feature extraction algorithm based on sparse LiDAR data. A novel method has been proposed for feature extraction from sparse LiDAR data. The algorithm and the related principles have been described. Also, I have tested and discussed the choices and roles of parameters. By using correlation of neighboring points directly, statistic distribution of normal vectors at each point has been effectively used to determine the category of the selected point. (II). Segmentation and 3D reconstruction of objects based on LiDAR/MRI. The proposed method includes that the 3D LiDAR data are layered, that different categories are segmented, and that 3D canopy surfaces of individual tree crowns and clusters of trees are reconstructed from LiDAR point data based on a region active contour model. The proposed method allows for delineations of 3D forest canopy naturally from the contours of raw LiDAR point clouds. The proposed model is suitable not …

POD (Point of Dispensing)-based emergency response plans involving mass prophylaxis may seem feasible when considering the choice of dispensing points within a region, overall population density, and estimated traffic demands. However, the plan may fail to serve particular vulnerable sub-populations, resulting in access disparities during emergency response. Federal authorities emphasize on the need to identify sub-populations that cannot avail regular services during an emergency due to their special needs to ensure effective response. Vulnerable individuals require the targeted allocation of appropriate resources to serve their special needs. Devising schemes to address the needs of vulnerable sub-populations is essential for the effectiveness of response plans. This research focuses on data-driven computational methods to quantify and address vulnerabilities in response plans that require the allocation of targeted resources. Data-driven methods to identify and quantify vulnerabilities in response plans are developed as part of this research. Addressing vulnerabilities requires the targeted allocation of appropriate resources to PODs. The problem of resource allocation to PODs during public health emergencies is introduced and the variants of the resource allocation problem such as the spatial allocation, spatio-temporal allocation and optimal resource subset variants are formulated. Generating optimal resource allocation and scheduling solutions can be computationally hard …

Publicly available datasets in health science are often large and observational, in contrast to experimental datasets where a small number of data are collected in controlled experiments. Variables' causal relationships in the observational dataset are yet to be determined. However, there is a significant interest in health science to discover and analyze causal relationships from health data since identified causal relationships will greatly facilitate medical professionals to prevent diseases or to mitigate the negative effects of the disease. Recent advances in Computer Science, particularly in Bayesian networks, has initiated a renewed interest for causality research. Causal relationships can be possibly discovered through learning the network structures from data. However, the number of candidate graphs grows in a more than exponential rate with the increase of variables. Exact learning for obtaining the optimal structure is thus computationally infeasible in practice. As a result, heuristic approaches are imperative to alleviate the difficulty of computations. This research provides effective and efficient learning tools for local causal discoveries and novel methods of learning causal structures with a combination of background knowledge. Specifically in the direction of constraint based structural learning, polynomial-time algorithms for constructing causal structures are designed with first-order conditional independence. Algorithms of …

There are several types of disorders that affect our colon’s ability to function properly such as colorectal cancer, ulcerative colitis, diverticulitis, irritable bowel syndrome and colonic polyps. Automatic detection of these diseases would inform the endoscopist of possible sub-optimal inspection during the colonoscopy procedure as well as save time during post-procedure evaluation. But existing systems only detects few of those disorders like colonic polyps. In this dissertation, we address the automatic detection of another important disorder called ulcerative colitis. We propose a novel texture feature extraction technique to detect the severity of ulcerative colitis in block, image, and video levels. We also enhance the current informative frame filtering methods by detecting water and bubble frames using our proposed technique. Our feature extraction algorithm based on accumulation of pixel value difference provides better accuracy at faster speed than the existing methods making it highly suitable for real-time systems. We also propose a hybrid approach in which our feature method is combined with existing feature method(s) to provide even better accuracy. We extend the block and image level detection method to video level severity score calculation and shot segmentation. Also, the proposed novel feature extraction method can detect water and bubble frames …

The history of mitigation programs to contain vector-borne diseases is a story of successes and failures. Due to the complex interplay among multiple factors that determine disease dynamics, the general principles for timely and specific intervention for incidence reduction or eradication of life-threatening diseases has yet to be determined. This research discusses computational methods developed to assist in the understanding of complex relationships affecting vector-borne disease dynamics. A computational framework to assist public health practitioners with exploring the dynamics of vector-borne diseases, such as malaria and dengue in homogenous and heterogeneous populations, has been conceived, designed, and implemented. The framework integrates a stochastic computational model of interactions to simulate horizontal disease transmission. The intent of the computational modeling has been the integration of stochasticity during simulation of the disease progression while reducing the number of necessary interactions to simulate a disease outbreak. While there are improvements in the computational time reducing the number of interactions needed for simulating disease dynamics, the realization of interactions can remain computationally expensive. Using multi-threading technology to improve performance upon the original computational model, multi-threading experimental results have been tested and reported. In addition, to the contact model, the modeling of biological processes specific to …

Managing large-scale dynamical systems (e.g., transportation systems, complex information systems, and power networks, etc.) in real-time is very challenging considering their complicated system dynamics, intricate network interactions, large scale, and especially the existence of various uncertainties. To address this issue, intelligent techniques which can quickly design decision-making strategies that are robust to uncertainties are needed. This dissertation aims to conquer these challenges by exploring a data-driven decision-making framework, which leverages big-data techniques and scalable uncertainty evaluation approaches to quickly solve optimal control problems. In particular, following techniques have been developed along this direction: 1) system modeling approaches to simplify the system analysis and design procedures for multiple applications; 2) effective simulation and analytical based approaches to efficiently evaluate system performance and design control strategies under uncertainty; and 3) big-data techniques that allow some computations of control strategies to be completed offline. These techniques and tools for analysis, design and control contribute to a wide range of applications including air traffic flow management, complex information systems, and airborne networks.

Epidemiologists rely on human interaction networks for determining states and dynamics of disease propagations in populations. However, such networks are empirical snapshots of the past. It will greatly benefit if human interaction networks are statistically predicted and dynamically created while an epidemic is in progress. We develop an application framework for the generation of human interaction networks and running epidemiological processes utilizing research on human mobility patterns and agent-based modeling. The interaction networks are dynamically constructed by incorporating different types of Random Walks and human rules of engagements. We explore the characteristics of the created network and compare them with the known theoretical and empirical graphs. The dependencies of epidemic dynamics and their outcomes on patterns and parameters of human motion and motives are encountered and presented through this research. This work specifically describes how the types and parameters of random walks define properties of generated graphs. We show that some configurations of the system of agents in random walk can produce network topologies with properties similar to small-world networks. Our goal is to find sets of mobility patterns that lead to empirical-like networks. The possibility of phase transitions in the graphs due to changes in the parameterization of agent …

In recent years, social media platforms such as Twitter and Facebook have emerged as effective tools for broadcasting messages worldwide during disaster events. With millions of messages posted through these services during such events, it has become imperative to identify valuable information that can help the emergency responders to develop effective relief efforts and aid victims. Many studies implied that the role of social media during disasters is invaluable and can be incorporated into emergency decision-making process. However, due to the "big data" nature of social media, it is very labor-intensive to employ human resources to sift through social media posts and categorize/classify them as useful information. Hence, there is a growing need for machine intelligence to automate the process of extracting useful information from the social media data during disaster events. This dissertation addresses the following questions: In a social media stream of messages, what is the useful information to be extracted that can help emergency response organizations to become more situationally aware during and following a disaster? What are the features (or patterns) that can contribute to automatically identifying messages that are useful during disasters? We explored a wide variety of features in conjunction with supervised learning algorithms …