This article describes a system for pupil size estimation with a user interface to allow rapid adjustment of parameters and extraction of pupil parameters of interest in order to identify Parkinson's disease (PD) as early as possible.

Article suggests that common standards for recording, detection, and reporting for intracranial recordings in humans that suggest their role in episodic and semantic memory does not exist. Authors of the article outline the methodological challenges involved in detecting ripple events and offer practical recommendations to improve separation from other high-frequency oscillations, and argue that shared experimental, detection, and reporting standards will provide a solid foundation for future translational discovery.

This article explores the short-term effects of extracellular Zn²⁺ on human smooth muscle cells.

Article states that high-frequency oscillation (HFO), classified as ripples (80-240 Hz) and fast ripples (240-500 Hz), is regarded as a promising biomarker of epilepsy. The authors presented an integrated, multi-layered procedure capable of automatically rejecting HFOs from a variety of common false positives, such as motion, background signals, and sharp transients.

This review compares the advantages and disadvantages of decellularization methods in terms of their ability to retain desired extracellular matrix characteristics for particular tissues and organs.

Article presents research where friction stir additive manufacturing technique was employed to fabricate AZ31B magnesium-hydroxyapatite composite. The study aims to evaluate effect of hydroxyapatite (HA, Ca₁₀(PO₄)₆OH₂), a ceramic similar to natural bone, into AZ31B Mg alloy matrix on biomineralization and biocompatibility.

Article provides a brief summary of state-of-art of surface biofunctionalization on implantable metals by CaP coatings.

Data management plan for the grant, "Targeted Systemic Delivery of SDF-1 DNA for the Treatment of Chronic Heart Disease."

Data management plan for the grant "CAREER: A Prosthetic Elbow with Network of Soft and Modular Thermo-Active Actuators for Mobility Impaired Patients." This NSF Faculty Early Career Development (CAREER) project will develop novel networks of flexible Peltier-based soft actuators designed for rehabilitation.

Article is a review highlighting the various cell types found in cardiac tissues and how they correspond with current advanced fabrication methods for creating cardiac engineered constructs.

Article develops vertically-aligned nanocrown electrodes that are mechanically robust and achieve > 99% success rates in obtaining intracellular access through electroporation. This technology development provides an advancement towards establishing an iAP screening assay for preclinical evaluation of drug-induced arrhythmogenicity.

Article describes study which sought to evaluate methods for activity recognition for toddlers.

This article develops a molecular cell tracker with a strong fluorescence signal in the second near-infrared (NIR-II) window (1,000-1,700 nm) for real-time monitoring of in vivo cell behaviors in both healthy and diseased animal models to address the issue of precisely and quantitatively evaluating the in vivo cell distribution, migration, and engraftment in stem cell therapy.

Data management plan for the grant, "New approach for identification pHFO networks to predict epilleptogenesis." About 40% of epilepsy patients fail to control seizures after treatment, and currently there is no treatment that can prevent epilepsy. The goal of this study is to perform multi-scale electrophysiological investigations combine with advanced computational algorithm development to understand the characteristics of the pathological brain networks during the latent period of epilepsy. The findings of this project will lead to a better understanding of the network mechanisms of epileptogenesis and suggest novel approaches to prevent the process of epileptogenesis.

Data management plan for the grant, "CAREER: Shape Memory Polymers as Biomaterial." This CAREER projectaimsto elucidate the underlying mechanism of the plasticization-induced shape memory effect of thiol-enebased polymers. The model application for this material will be a heat shrink tubing that can shrink at bodily conditions (37° C and simulated body fluids) and can be used to seal colonic anastomosis. The specific three aims are to (1) Systematically investigate the effect of crosslink-density and chain extender length on theplasticization-induced shape memory effect of thiol-enebased polymers. Mechanical and thermomechanical measurements inside simulated body fluids will be used to assess shape memory properties and structure-property relationships. (2) Understand the relationship between material thickness, degree of shape-programming, and radial recovery forces of tube-shaped SMPs to determine optimal design parameters for sufficient shape recovery using the heat shrink tube model. (3) Demonstrate the functionality of a biomedical heat shrink tube that utilizes the plasticization-induced shape recovery through an ex vivo colon anastomosis model and quantify mechanical and sealing properties.

Data management plan for the grant, "Mechanoregulators of Nanoparticle-Cell Interactions at Tissue Interfaces."

Data management plan for the grant, "UNT Texas Fashion Collection: Assessment and Preservation Training."

Data management plan for the grant, "New approach based on enzyme stimulating of peptides for targeting drug resistance breast cancers." In this project, we propose the development of selective self-assembling peptides that form nanofibers via a self-assembling process upon the action of Eyes absent (EYA) enzyme, specific to drug resistance Triple Negative Breast cancer cells (TNBC). The objectives are: Aim 1: Design and synthesize self-assembling peptide substrates for EYA enzymes; Aim 2:Determining the efficacy of peptide substrates for inhibiting TNBC in spheroid 3D cell cultures. The correlation between the enzyme kinetic and the activity of nanostructures for targeting EYA will be evaluated. Aim 3: The apoptosis response of the TNBC cells will be determined. This study will lead to finding the potent peptide substrate and the effective dose for inhibiting TNBC cells with apoptosis cell death.

Data management plan for the grant, "Child Health and Human Development Extramural Research." This study will use the genome-edited human induced pluripotent stem cell (hiPSC) with NOTCH1 knockout to recapitulate the genetic variants of NOTCH1 mutation in the Hypoplastic left heart syndrome (HLHS). It will use advances in the vascularized cardiac organoid directly differentiated from hiPSCs to replay the development and function of cardiomyocytes, endothelial cells, smooth muscle cells, and other cardiac cells in a defined 3D cell culture model by stencil-based micropatterning. It will elucidate the pathogenesis of cardiovascular underdevelopment and dysfunction found in HLHS with NOTCH1 mutation via the NOTCHDELTA/JAG ligand-receptor binding and multicellular crosstalk by single-cell RNA-seq and proteomics analysis.

Data management plan for the grant, "Optic-nerve-head (ONH) Chips for Glaucomatous Neurodegeneration." The most prominent causative risk factor of glaucoma, the leading cause of irreversible blindness worldwide, is elevated intraocular pressure (IOP), which could deform the optic nerve head (ONH) and cause glaucomatous neurodegeneration. However, current glaucoma therapies that focus on lowering IOP do not stop vision loss effectively, and thus there is a pressing need to understand the mechanisms underlying glaucoma pathogenesis. In this project, we will develop a biomimetic 3-D ONH-on-a-chip system that closely mimics the key anatomical and pathophysiological characteristics of the native ONH to study astrocytic mechanisms of glaucoma pathogenesis, a missing link to develop efficacious therapies.

Article asserts that while techniques that allow one to control the arrangement of cells and direct contact between different cell types have been developed that expand upon simple co-culture methods, specific control over heterojunctions that form between cells is not easily accomplished with current methods, such as 3D cell-printing. In this article, DNA-mediated cell interactions are combined with cell-compatible photolithographic approaches to control cell assembly.

Article describes how cell-derived extracellular matrix has become increasingly popular in tissue engineering applications due to its ability to provide tailored signals for desirable cellular responses. The objective of this study was to assess the efficacy of two detergent-based decellularization methods: a combination of ethylenediaminetetraacetic acid and sodium dodecyl sulfate and a combination of sodium deoxycholate and deoxyribonuclease.

Article states that although KRASG12C inhibitors have shown promising activity in lung adenocarcinomas harboring KRASG12C, acquired resistance to these therapies eventually occurs in most patients. The authors report that the hedgehog signal is induced by KRASG12C inhibitors and mediates KRAS re-expression in cancer cells treated with a KRASG12C inhibitor.

Article describes how the presented research highlights a novel approach using fmoc-protected peptide hydrogels for the encapsulation and stretching of mesenchymal stem cells. This study utilized a custom mechanical stretching device with a PDMS chamber to stretch human mesenchymal stem cells encapsulated in Fmoc hydrogels.