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Development of Genetic Sensors and Circuits for Creating Novel Cellular Behaviors (open access)

Development of Genetic Sensors and Circuits for Creating Novel Cellular Behaviors

Data management plan for the grant "Development of Genetic Sensors and Circuits for Creating Novel Cellular Behaviors." This research is expected to advance the capability to engineer organisms for biomedical uses. Specifically, the outcomes of this project include design principles for engineering regulators from different protein families, an extensive set of genetic sensors for detecting a broad range of signals, and novel genetic circuits that address uprising problems in biomedical fields. It uses a novel multidisciplinary approach to enhance the health of the nation by creating tools that facilitate both medical-related discoveries and the implementation of new strategies for biomedical applications.
Date: 2021-09-15/2026-08-31
Creator: Chan, Clement T. Y.
System: The UNT Digital Library
New approach for identification pHFO networks to predict epilleptogenesis (open access)

New approach for identification pHFO networks to predict epilleptogenesis

Data management plan for the grant, "New approach for identification pHFO networks to predict epilleptogenesis." About 40% of epilepsy patients fail to control seizures after treatment, and currently there is no treatment that can prevent epilepsy. The goal of this study is to perform multi-scale electrophysiological investigations combine with advanced computational algorithm development to understand the characteristics of the pathological brain networks during the latent period of epilepsy. The findings of this project will lead to a better understanding of the network mechanisms of epileptogenesis and suggest novel approaches to prevent the process of epileptogenesis.
Date: 2022-07-15/2026-06-30
Creator: Li, Lin
System: The UNT Digital Library