This review compares the advantages and disadvantages of decellularization methods in terms of their ability to retain desired extracellular matrix characteristics for particular tissues and organs.

This review article will focus on known risks following iron oxide nanoparticles (IONPs) exposure supported by human, animal, and cell culture-based studies, the potential challenges intrinsic to IONPs toxicity assessment, and how these may contribute to the poorly characterized IONPs toxicity profile.

This article explores the short-term effects of extracellular Zn²⁺ on human smooth muscle cells.

Article evaluating whether advanced prostheses can provide better safety and performance capabilities to maintain and improve quality of life in individuals who are predominantly designated MFCL level K2. This study used a 13 month longitudinal clinical trial to determine the benefits of using a C-Leg and 1M10 foot in individuals at K2 level with transfemoral amputation due to vascular disease.

This article explores a proposed deep-learning-based algorithm called DeepFilter for improving peptide identifications from a collection of tandem mass spectra. The authors find that DeepFilter is believed to generalize properly to new, previously unseen peptide-spectrum-matches and can be readily applied in peptide identification from metaproteomics data.

Data management plan for the grant "Modulating 3D Cellular Connectivity Via Spatially-Controlled Programmable Bonding." This project seeks to demonstrate proof-of-concept for technology that allows one to systematically place cells on substrates to create complex 3D assemblies with precise control over individual cellular interactions. The technology generated within this proposal will open new avenues for studying multicellular communication pathways, stem cell differentiation, and understanding developmental processes. Spatially-defined cell-cell communication plays a critical role in numerous disease and developmental processes that include osteoarthritic degeneration, cancer metastasis, and organ regeneration.

Data management plan for the grant "Development of Genetic Sensors and Circuits for Creating Novel Cellular Behaviors." This research is expected to advance the capability to engineer organisms for biomedical uses. Specifically, the outcomes of this project include design principles for engineering regulators from different protein families, an extensive set of genetic sensors for detecting a broad range of signals, and novel genetic circuits that address uprising problems in biomedical fields. It uses a novel multidisciplinary approach to enhance the health of the nation by creating tools that facilitate both medical-related discoveries and the implementation of new strategies for biomedical applications.

Article provides a brief summary of state-of-art of surface biofunctionalization on implantable metals by CaP coatings.

Article describes study which indicates that nuclear type 2C protein phosphatase (PP2Cδ) impairs p53 acetylation and DNA damage response by compromising BRCA1 function in breast cancer development.

Article presents a 3D body imaging system built upon stereovision technology which utilizes paired, high-resolution single-lens reflex (SLR) cameras to image the front and back body surfaces of a person, and robust and efficient stereo matching algorithms to reconstruct the 3D surface of the body with high-density data clouds.

This article showcasing the editorial team welcomes all readers to the proceedings of International Conference on Recent Advancements in Biomedical Engineering (ICRABE-2021). The conference was inspired by the fusion of science and engineering principles in healthcare services and products. The conference aims to initiate exchange of innovative ideas between students, research scholar and faculties. Specifically, mechanical principles, power control for medical devices, nanomaterials and associated technologies were focused. This proceeding comprises of a broad spectrum of techniques to expose the recent advancements in the field of physics for healthcare application. A List of the Organizing Committee, Advisory Committee, Technical Committee are available in the pdf.

This article is a review summarizing the significant roles of Notch signaling in individual cardiac cell types. It covers the bioengineering systems of microfluidics, hydrogel, spheroid, and 3D bioprinting and provides insights into ancillary supports of bioengineering systems, varied types of cardiovascular cells, and advanced characterization approaches in further refining Notch signaling in cardiovascular development, disease, and regeneration.

Data management plan for the grant "CAREER: A Prosthetic Elbow with Network of Soft and Modular Thermo-Active Actuators for Mobility Impaired Patients." This NSF Faculty Early Career Development (CAREER) project will develop novel networks of flexible Peltier-based soft actuators designed for rehabilitation.

Data management plan for the grant, "Child Health and Human Development Extramural Research." This study will use the genome-edited human induced pluripotent stem cell (hiPSC) with NOTCH1 knockout to recapitulate the genetic variants of NOTCH1 mutation in the Hypoplastic left heart syndrome (HLHS). It will use advances in the vascularized cardiac organoid directly differentiated from hiPSCs to replay the development and function of cardiomyocytes, endothelial cells, smooth muscle cells, and other cardiac cells in a defined 3D cell culture model by stencil-based micropatterning. It will elucidate the pathogenesis of cardiovascular underdevelopment and dysfunction found in HLHS with NOTCH1 mutation via the NOTCHDELTA/JAG ligand-receptor binding and multicellular crosstalk by single-cell RNA-seq and proteomics analysis.

Article reviewing several several flexible and stretchable materials used as substrate, stretchable electrical conduits and encapsulation, design modifications for stretchability, fabrication techniques, methods of signal transmission and monitoring, and the power sources for these stretchable bioelectronics. Ultimately, these bioelectronic devices can be used for wide range of applications from skin bioelectronics and biosensing devices, to neural implants for diagnostic or therapeutic purposes.

Article is a review highlighting the various cell types found in cardiac tissues and how they correspond with current advanced fabrication methods for creating cardiac engineered constructs.

This review article summarizes the latest neuropathological discoveries at the molecular, cellular, and tissue levels involving both animal and patient studies, aiming to explore epileptogenesis and highlight new potential targets in the diagnosis and treatment of temporal lobe epilepsy (TLE).

This article presents a consolidated review of Independent Component Analysis (ICA) as an efficient neural coding scheme with the ability to model early visual and auditory neural processing.

Article develops vertically-aligned nanocrown electrodes that are mechanically robust and achieve > 99% success rates in obtaining intracellular access through electroporation. This technology development provides an advancement towards establishing an iAP screening assay for preclinical evaluation of drug-induced arrhythmogenicity.

Article examines the roles of all major players in the biocompatibility of zinc, i.e., zinc phosphate (ZnP), zinc oxide (ZnO), zinc hydroxide (Zn(OH)2), pH, and Zn2+.

Article discusses the role of Mg2+ in regulating vascular functions.

Corrigendum to the article titled “Metabolic Syndrome, Inflammation, and Cancer”.

Article introducing a special issue discussing the link between the metabolic syndrome and the development and progression of cancer. The role of inflammation in these diseases and identification of new therapeutic targets are of great significance. This special issue contributes original research papers and review articles that motivate the continuous efforts to comprehend the mechanisms, production, and management related to cancers associated with the metabolic syndrome.

Article describes study which sought to evaluate methods for activity recognition for toddlers.