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Quantitative Studies of Inhibitors of ADP-ribosylation in Vitro and in Vivo (open access)

Quantitative Studies of Inhibitors of ADP-ribosylation in Vitro and in Vivo

Article evaluating the selectivity of compounds originally identified as inhibitors of poly(ADP-ribose) polymerase on members of the three classes of enzymes. The results suggest that micromolar levels of the benzamides in the culture medium should allow selective inhibition of poly(ADP-ribose) metabolism in intact cells. Furthermore, comparative quantitative inhibition studies should prove useful for assigning the biological effects of these inhibitors as an effect on either poly(ADP-ribose) or mono(ADP-ribose) metabolism.
Date: March 15, 1989
Creator: Rankin, Patrick W.; Jacobson, Elaine L.; Benjamin, Robert C.; Moss, Joel & Jacobson, Myron K.
System: The UNT Digital Library