According to an Administration national security strategy document released on March 16, 2006, the United States "may face no greater challenge from a single country than Iran." The Bush Administration announced May 31, 2006, that it would negotiate with Iran in concert with U.S. allies. If diplomacy and sanctions do not succeed, some advocate military action against Iran's nuclear infrastructure rather than acquiescence to a nuclear-armed Iran. U.S. concerns regarding Iran include Iran's nuclear program, Iran's influence on Iraq by way of providing arms and other material assistance to Shiite Islamist militias, and Iran's human rights practices, which include strict limits on free expression and repression of ethnic and religious minorities.

According to the Administration’s “National Security Strategy” document released on March 16, 2006, the United States “may face no greater challenge from a single country than Iran.” That perception might have intensified in the context of Iran ally Lebanese Hizballah’s military challenge to Israel in July 2006. To date, the Bush Administration has pursued several avenues to attempt to contain the potential threat posed by Iran, including supporting a long-term policy of changing Iran’s regime. However, the near-term Administration drive to prevent any Iranian nuclear weapons breakthrough has brought diplomatic and economic strategies to the forefront of U.S. policy.

Report discussing U.S. concerns with Iran, including concerns relating to endorsements given to terrorist organizations by the Iranian government, nuclear weaponry, and human rights practices.