Some diagnostics at the National Ignition Facility (NIF), including the Gamma Reaction History (GRH) diagnostic, require multiple channels of data to achieve the required dynamic range. These channels need to be stitched together into a single time series, and they may have non-uniform and redundant time samples. We chose to apply the popular cubic smoothing spline technique to our stitching problem because we needed a general non-parametric method. We adapted one of the algorithms in the literature, by Hutchinson and deHoog, to our needs. The modified algorithm and the resulting code perform a cubic smoothing spline fit to multiple data channels with redundant time samples and missing data points. The data channels can have different, time-varying, zero-mean white noise characteristics. The method we employ automatically determines an optimal smoothing level by minimizing the Generalized Cross Validation (GCV) score. In order to automatically validate the smoothing level selection, the Weighted Sum-Squared Residual (WSSR) and zero-mean tests are performed on the residuals. Further, confidence intervals, both analytical and Monte Carlo, are also calculated. In this paper, we describe the derivation of our cubic smoothing spline algorithm. We outline the algorithm and test it with simulated and experimental data.

Congressional interest in wetlands permit regulatory programs has been evident in the past in oversight hearings and in connection with bills to fund the Corps' regulatory programs. For some time, there has been a stalemate over legislation that would revise wetlands regulatory law and that could, if enacted, modify the nationwide permit program. During this time, no consensus has emerged on whether or how to reform overall wetlands policy legislatively. Recently, Obama Administration initiatives and actions intended to restrict harmful effects of surface coal mining activities in Appalachia have drawn congressional attention and criticism that is likely to continue in the 112th Congress and that could include oversight of the Corps' regulatory program generally.

This report provides a brief survey of China-North Korea relations, assesses China's objectives and actions, and raises policy issues for the United States.

Daily publication of the U.S. Office of the Federal Register contains rules and regulations, proposed legislation and rule changes, and other notices, including "Presidential proclamations and Executive Orders, Federal agency documents having general applicability and legal effect, documents required to be published by act of Congress, and other Federal agency documents of public interest" (p. ii). Table of Contents starts on page iii.

The focus of the CEHMM award was alternative energy research and education. The objective of the CEHMM algae to biodiesel project was to determine the viability and feasibility of using algae as a feedstock for commercial biodiesel production. The project investigated the propagation, harvesting and extraction of oil from a salt/brine water algae in open raceway ponds.

This report discusses the Financial Services and General Government (FSGG) FY2011 appropriations bill, which includes funding for the Department of the Treasury, the Executive Office of the President (EOP), the judiciary, the District of Columbia, and 26 independent agencies, including the Small Business Administration and the United States Postal Service.

This is a report regarding the November 2010 Lisbon Summit, wherein alliance heads of the North Atlantic Treaty Organization approved a plan to integrate existing NATO members ballistic missile defense capabilities into their overall defense posture. This report looks at advantages, challenges, and current Congressional legislation regarding the Obama Administration's Phased Adaptive Approach, which would be regional ballistic missile defense capability in Europe.

We have used the TOUGH2-MP/ECO2N code to perform numerical simulation studies of the long-term behavior of CO{sub 2} stored in an aquifer with a sloping caprock. This problem is of great practical interest, and is very challenging due to the importance of multi-scale processes. We find that the mechanism of plume advance is different from what is seen in a forced immiscible displacement, such as gas injection into a water-saturated medium. Instead of pushing the water forward, the plume advances because the vertical pressure gradients within the plume are smaller than hydrostatic, causing the groundwater column to collapse ahead of the plume tip. Increased resistance to vertical flow of aqueous phase in anisotropic media leads to reduced speed of updip plume advancement. Vertical equilibrium models that ignore effects of vertical flow will overpredict the speed of plume advancement. The CO{sub 2} plume becomes thinner as it advances, yet the speed of advancement remains constant over the entire simulation period of up to 400 years, with migration distances of more than 80 km. Our simulations include dissolution of CO{sub 2} into the aqueous phase and associated density increase, and molecular diffusion. However, no convection develops in the aqueous phase because it …

This report discusses the Commerce Clause of the United States Constitution, which provides that the Congress shall have the power to regulate interstate and foreign commerce.

At-tank supplemental pretreatment including both filtration and small column ion exchange is currently under evaluation to facilitate salt waste retrieval and processing in the Hanford tank farms. Spherical resorcinol formaldehyde (sRF) resin is the baseline ion exchange resin for use in the Waste Treatment and Immobilization Plant (WTP). This document provides background and technical rationale to assist in determining whether spherical resorcinol formaldehyde (sRF) is also the appropriate ion exchange resin for supplemental LAW pretreatment processes and compares sRF with crystalline silicotitanate (CST) as potential supplemental pretreatment ion exchange media.

A security study performed by Grant Thornton LLP for the Texas Lottery Commission to evaluate security measures established by management to support the integrity and security of the Texas Lottery's operations, gaming services and instant and on-line ticket productions.

About 50 million gallons of high-level mixed waste is currently stored in underground tanks at The United States Department of Energy's (DOE's) Hanford site in the State of Washington. The Hanford Tank Waste Treatment and Immobilization Plant (WTP) will provide DOE's Office of River Protection (ORP) with a means of treating this waste by vitrification for subsequent disposal. The tank waste will be separated into low- and high-activity waste fractions, which will then be vitrified respectively into Immobilized Low Activity Waste (ILAW) and Immobilized High Level Waste (IHLW) products. The ILAW product will be disposed in an engineered facility on the Hanford site while the IHLW product will likely be directed to a national deep geological disposal facility for high-level nuclear waste. The ILAW and IHLW products must meet a variety of requirements with respect to protection of the environment before they can be accepted for disposal. The Office of River Protection is currently examining options to optimize the Low Activity Waste (LAW) Facility and LAW glass waste form. One option under evaluation is to enhance the waste processing rate of the vitrification plant currently under construction. It is likely that the capacity of the LAW vitrification plant can be …

Since the development of new antibiotics is out-paced by the emergence of bacterial resistance to existing antibiotics, it is crucial to understand the genetic mechanisms underlying resistance existing antibiotics. At the center of this mystery is a poorly understood phenomenon, heteroresistance: the coexistence of multiple subpopulations with varying degrees of antibiotic resistance. A better understanding of the fundamental basis of heteroresistance could result in sorely needed breakthroughs in treatment options. This project proposed to leverage a novel microfluidic (microchemostat) technology to probe the heteroresistance phenomenon in bacteria, with the aim of restoring the efficacy of existing {beta}-lactam antibiotics. The clinically important bacteria Methicillin Resistant S. aureus (MRSA) was used as the test case of bacteria that exhibits antibiotic heteroresistance. MRSA is difficult to treat because it is resistant to all {beta}-lactam antibiotics, as well as other classes of antimicrobials. Whereas {beta}-lactams such as methicillin and oxacillin are the preferred antibiotics to treat S. aureus infections due to their efficacy and low side effects, accurate determination and use of oxacillin/methicillin dosage is hampered by heteroresistance. In fact, invasive MRSA infections now account for about 95,000 deaths per year, a number that exceeds the deaths due to either influenza or HIV (12). …

Parent map for Loving County, Texas showing the area of one geographic block for which the U.S. Census Bureau collected data. The plotted map scale is 1:33,000.

Parent map for Loving County, Texas showing the area of one geographic block for which the U.S. Census Bureau collected data. The plotted map scale is 1:33,000.

Parent map for Loving County, Texas showing the area of one geographic block for which the U.S. Census Bureau collected data. The plotted map scale is 1:33,000.

Parent map for Loving County, Texas showing the area of one geographic block for which the U.S. Census Bureau collected data. The plotted map scale is 1:33,000.

Parent map for Loving County, Texas showing the area of one geographic block for which the U.S. Census Bureau collected data. The plotted map scale is 1:33,000.

Index map for Loving County, Texas showing the distribution of census blocks and smaller inset areas for which the U.S. Census Bureau collected data. The plotted map scale is 1:101,327.

Inset map for Loving County, Texas showing detail within a census block for which the U.S. Census Bureau collected data. The plotted map scale is 1:6,853.

Parent map for Martin County, Texas showing the area of one geographic block for which the U.S. Census Bureau collected data. The plotted map scale is 1:18,000.

Parent map for Martin County, Texas showing the area of one geographic block for which the U.S. Census Bureau collected data. The plotted map scale is 1:18,000.

Parent map for Martin County, Texas showing the area of one geographic block for which the U.S. Census Bureau collected data. The plotted map scale is 1:18,000.

Parent map for Martin County, Texas showing the area of one geographic block for which the U.S. Census Bureau collected data. The plotted map scale is 1:18,000.