Article on the first-principles theory of metal-alkaline earth oxide interfaces.

Flow cytometric assays of human erythrocytes labeled with monoclonal antibodies specific for glycophorin A were used to enumerate variant cells that appear in peripheral blood as a result of somatic gene-loss mutations in erythrocyte precursor cells. The assay was performed on erythrocytes from 10 oncology patients who had received at least one treatment from radiation or mutagenic chemotherapy at least 3 weeks before being assayed. The patients were suffering from many different malignancies (e.g., breast, renal, bone, colon and lung), and were treated with several different mutagenic therapeutics (e.g., cisplatinum, adriamycin, daunomycin, or cyclophosphamide). The frequency of these variant cells is an indication of the amount of mutagenic damage accumulated in the individual's erythropoietic cell population. Comparing these results to HPRT clonogenic assays, we find similar baseline frequencies of somatic mutation as well as similar correlation with mutagenic exposures. 9 refs., 3 figs., 1 tab.

The laser resonance absorption technique has been used to determine the relaxation rate of electronically excited neodymium vapor during its expansion into vacuum. Significant increases of population into ground and 1128 cm/sup -1/ levels were found. Analysis shows that interaction between excited metastable atoms and electrons are much more important for relaxation than atom-atom collisions. The final population of neodymium appears to be frozen at a temperature lower than the surface temperature of melt.

Article on protein sequence classification using feature hashing.

Article discussing research that shows both music composition and brain function, as revealed by the electroencephalogram (EEG) analysis, are renewal non-Poisson processes living in the nonergodic dominion.

Diseases and conditions affecting the lower urinary tract are a leading cause of dysfunctional sexual health, incontinence, infection, and kidney failure. The growth, differentiation, and repair of the bladder's epithelial lining are regulated, in part, by fibroblast growth factor (FGF)-7 and -10 via a paracrine cascade originating in the mesenchyme (lamina propria) and targeting the receptor for FGF-7 and -10 within the transitional epithelium (urothelium). The FGF-7 gene is located at the 15q15-q21.1 locus on chromosome 15 and four exons generate a 3.852-kb mRNA. Five duplicated FGF-7 gene sequences that localized to chromosome 9 were predicted not to generate functional protein products, thus validating the use of FGF-7-null mice as an experimental model. Recombinant FGF-7 and -10 induced proliferation of human urothelial cells in vitro and transitional epithelium of wild-type and FGF-7-null mice in vivo.To determine the extent that induction of urothelial cell proliferation during the bladder response to injury is dependent on FGF-7, an animal model of partial bladder outlet obstruction was developed. Unbiased stereology was used to measure the percentage of proliferating urothelial cells between obstructed groups of wild-type and FGF-7-null mice. The stereological analysis indicated that a statistical significant difference did not exist between the two groups, …

Plutonium is a very complex element lying near the middle of the actinide series. On the lower atomic number side of Pu is the element neptunium; its 5f electrons are highly delocalized or itinerant, participating in metallic-like bonding. The electrons in americium, the element to the right of Pu, are localized and do not participant significantly in the bonding. Plutonium is located directly on this rather abrupt transition. In the low-temperature {alpha} phase ground state, the five 5f electrons are mostly delocalized leading to a highly dense monoclinic crystal structure. Increases in temperature take the unalloyed plutonium through a series of five solid-state allotropic phase transformations before melting. One of the high temperature phases, the close-packed face centered cubic {delta} phase, is the least dense of all the phases, including the liquid. Alloying the Pu with Group IIIA elements such as aluminum or gallium retains the {delta} phase in a metastable state at ambient conditions. Ultimately, this metastable {delta} phase will decompose via a eutectoid transformation to {alpha} + Pu{sub 3}Ga. These low solute-containing {delta}-phase Pu alloys are also metastable with respect to low temperature excursions or increases in pressure and will transform to a monoclinic crystal structure at low …

Thermally activated barrier crossing in the presence of an increasing load can reveal kinetic rate constants and energy barrier parameters when repeated over a range of loading rates. Here we derive a model of the mean escape force for all relevant loading rates--the complete force spectrum. Two well-known approximations emerge as limiting cases; one of which confirms predictions that single-barrier spectra should converge to a phenomenological description in the slow loading limit.

The dispersion of pollutants from the ground by turbulent winds is difficult to model in general. However, for flat homogeneous terrain and steady wind conditions, if the wind profile is modeled with a power-law dependence on height, the advection-dispersion equation has an exact solution. In this paper the analytical solution is compared to a numerical simulation of the coupled air-ground system for a leaking underground gas storage, with a power-law velocity profile that was fit to the logarithmic velocity profile used in the simulation. The two methods produced similar results far from the boundaries, but the boundary conditions had a strong effect; the simulation imposed boundary conditions at the edge of a finite domain while the analytic solution imposes them at infinity. The reverse seepage from air to ground was shown in the simulation to be very small, and the sharp contrast between time scales suggests that air and ground can be modeled separately, with gas emissions from the ground model used as inputs to the air model.

Total and partial charge-changing cross sections have been measured for argon projectiles at 400 MeV/nucleon in carbon, aluminum, copper, tin and lead targets; cross sections for hydrogen were also obtained, using a polyethylene target. The validity of weak and strong factorization properties has been investigated for partial charge-changing cross sections; preliminary cross section values obtained for carbon, neon and silicon at 290 and 400 MeV/nucleon and iron at 400 MeV/nucleon, in carbon, aluminum, copper, tin and lead targets have been also used for testing these properties. Two different analysis methods were applied and both indicated that these properties are valid, without any significant difference between weak and strong factorization. The factorization parameters have then been calculated and analyzed in order to find some systematic behavior useful for modeling purposes.

The beam dynamics for a quasi-isochronous lattice differs from that in the usual case of a lattice with a large positive momentum compaction factor. In particular, the quasi-isochronous lattice allows us to double the number of bunches which may be an attractive option for colliders. However, microwave instability and, as we show, longitudinal head-tail instability set the threshold for the beam current.

Vacuum arc ion sources, commonly also known as "Mevva" ionsources, are used to generate intense pulsed metal ion beams. It is knownthat the mean charge state of the ion beam lies between 1 and 4,depending on cathode material, arc current, arc pulse duration, presenceor absence of magnetic field at the cathode, as well background gaspressure. A characteristic of the vacuum arc ion beam is a significantdecrease in ion charge state throughout the pulse. This decrease can beobserved up to a few milliseconds, until a "noisy" steady-state value isestablished. Since the extraction voltage is constant, a decrease in theion charge state has a proportional impact on the average ion beamenergy. This paper presents results of detailed investigations of theinfluence of arc parameters on the temporal development of the ion beammean charge state for a wide range of cathode materials. It is shown thatfor fixed pulse duration, the charge state decrease can be reduced bylower arc current, higher pulse repetition rate, and reduction of thedistance between cathode and extraction region. The latter effect may beassociated with charge exchange processes in the dischargeplasma.

A new type of compact induction accelerator is under development at the Lawrence Livermore National Laboratory that promises to increase the average accelerating gradient by at least an order of magnitude over that of existing induction machines. The machine is based on the use of high gradient vacuum insulators, advanced dielectric materials and switches and is stimulated by the desire for compact flash x-ray radiography sources. Research describing an extreme variant of this technology aimed at proton therapy for cancer will be described. Progress in applying this technology to several applications will be reviewed.

Handling the power and particle exhaust in fusion reactors based on tokamaks is a challenging problem [1,2]. To bring the energy flux to the divertor plates to an acceptable level (< 10 MW/m2), it is desirable to significantly increase poloidal flux expansion in the divertor area. Some recent ideas include that of a so-called X divertor [3] and a 'snowflake' divertor [4]. We use an acronym SF to designate the latter. In this paper we concentrate on the SF divertor. The general idea behind this configuration is that, by a proper selection of divertor (poloidal field) coils, one can make the null point of the second, not of the first order as in the standard divertor. The separatrix in the vicinity of the X point then acquires a characteristic hexapole structure (Fig. 1), reminiscent of a snowflake, whence the name. The fact that the field has a second-order null, leads to a significant increase of the flux expansion. It was noted in Ref. [4] that the SF configuration is topologically unstable: if the current in the divertor coils is somewhat higher than the one that provides the SF configuration, it becomes a single-null X-point configuration. Conversely, if the coil current …

Immiscibility in the trevorite (NiFe{sub 2}O{sub 4}) - franklinite (ZnFe{sub 2}O{sub 4}) spinel binary is investigated by reacting 1:1:2 molar ratio mixtures of NiO, ZnO and Fe{sub 2}O{sub 3} in a molten salt solvent at temperatures in the range 400-1000 C. Single phase stability is demonstrated down to about 730 C (the estimated consolute solution temperature, T{sub cs}). A miscibility gap/solvus exists below Tcs. The solvus becomes increasingly asymmetric at lower temperatures and extrapolates to n - values = 0.15, 0.8 at 300 C. A thermodynamic analysis, which accounts for changes in configurational and magnetic ordering entropies during cation mixing, predicts solvus phase compositions at room temperature in reasonable agreement with those determined by extrapolation of experimental results. The delay between disappearance of magnetic ordering above T{sub C} = 590 C (for NiFe{sub 2}O{sub 4}) and disappearance of a miscibility gap at T{sub cs} is explained by the persistence of long-range ordering correlations in a quasi-paramagnetic region above T{sub C}.

The objective is to investigate whether existing technology might be extrapolated to provide the conceptual framework for a major hadron-hadron collider facility for high energy physics experimentation for the remainder of this century. One contribution to this large effort is to formalize the methods and mathematical tools necessary. In this report, the main purpose is to introduce the student to basic design procedures. From these follow the fundamental characteristics of the facility: its performance capability, its size, and the nature and operating requirements on the accelerator components, and with this knowledge, we can determine the technology and resources needed to build the new facility.

This presentation reviews current and proposed standards, recommendations, and guidances for limiting routine radiation exposures of the public, and estimates the risk corresponding to standards, recommendations, and guidances. These estimates provide a common basis for comparing different criteria for limiting public exposures to radiation, as well as hazardous chemicals.

Performance models for a two-phase turbine were developed to verify the understanding of the loss mechanisms and to extrapolate from the single-nozzle test condition to a full-admission turbine. The numerical models for predicting the performance of the nozzle and the combined nozzle and rotor are described. Results from two-phase, static cascade tests and disk-friction and windage experiments are used to calibrate the performance model(s). Model predictions are compared with single-nozzle prototype-turbine test results, and extrapolations are made to a full-admission design. The modeling also provides predictions of performance for turbines with various blade geometries, inlet conditions, and droplet sizes. Thus the modeling provides insight into design improvements.

We have designed, developed, and calibrated three different types of nondestructive assay systems for the Savannah River Plant (SRP). These systems will be delivered to SRP in 1986 and become part of the nuclear material accounting instrumentation at one of SRP's reprocessing facilities. Among the various types of nondestructive assay systems to be implemented are a neutron counter (Los Alamos National Laboratory - LANL), a four-station calorimeter (Mound Laboratories), a waste solution assay system (LANL), two gamma-ray solution concentration assay systems (LLNL), two x-ray fluorescence analysis concentration assay systems (LLNL), and one 2-detector plutonium solids isotopics system (LLNL). Los Alamos also has the responsibility of combining the individual measurement systems into an integrated accountability capability. Each NDA instrument will report results to a central Instrument Control Computer (ICC). Figure 1 illustrates schematically the integrated system with each Laboratory's contribution shown by dotted lines.

A large cantilevered mirror was constructed to focus the vertical divergence from a synchrotron radiation source. The advantages of this mirror are its compactness, simple bending device, simplicity of construction, and good thermal contact to structures outside the vacuum. The central portion of the mirror is supported with variable loading springs to reduce gravitational sag. The figure and thermal stability of the mirror have proven to be excellent, though the focusing is limited by the roughness of the mirror-surface. This paper describes the design, construction, and performance of the mirror.

Prior to 1988, a variety of materials were buried on the US DOE Oak Ridge Reservation. Records of the disposal operations are incomplete and toxic materials may have been placed adjacent to potential explosives. One of the safety concerns in conducting an environmental restoration project at the burial sites, is the possibility of an explosion which could release toxic materials to the atmosphere. A safety analysis examined the consequences of such releases by first postulating an upper bound for the strength of an explosive. A correlation, developed by Steindler and Seefeldt of Argonne National Laboratory, was then used to estimate the amount and particle-size distribution of the material that could become airborne from the explosion. The estimated amount of airborne material was the source term in an atmospheric dispersion model which was used to calculate infinite-time, concentration-time integrals and 5-minute, time- weighted average concentrations at locations down-wind from the explosion. The dispersion model includes particle deposition as a function of particle-size distribution class. The concentration-time integrals and average concentrations were compared to published guidelines to assess the consequences of an accidental explosion.

In order to obtain sufficient cooling rates for the Relativistic Heavy Ion Collider (RHIC) electron cooling, a bunched beam with high bunch charge, high repetition frequency and high energy is required and it is necessary to use a ''magnetized'' beam, i.e., an electron beam with non-negligible angular momentum. Applying a longitudinal solenoid field on the cathode can generate such a beam, which rotates around its longitudinal axis in a field-free region. This paper suggests how a magnetized beam can be accelerated and transported from a RF photocathode electron gun to the cooling section without significantly increasing its emittance. The evolution of longitudinal slices of the beam under a combination of space charge and magnetization is investigated, using paraxial envelope equations and numerical simulations. We find that we must modify the traditional method of compensating for emittance as used for normal non-magnetized beam with space charge to account for magnetization. The results of computer simulations of successful compensation are presented. Alternately, we show an electron bunch density distribution for which all slices propagate uniformly and which does not require emittance compensation.

In this paper we discuss detection prospects by combining two different aspects of the gamma-ray signal: the angular distribution and the photon counts probability distribution function (PDF).

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