Nuclear physics research with 22-Mev protons in the 86-in. cyclotron included angular-distribution measurements of neutrons from (p,n) reactions in nine target elements; measurement of the angular distribution of fission fragments from proton-induced fission of U233, U225, U228, Th230, and Th232; measurement of alpha-particle angular distributions from (p,α) reactions a study of the neutron-deficient isotopes of terbium and completion of an extensive program of the measurement of activation cross sections. Two more targets for cyclotron production of isotopes were developed, and the production yields for 14 radioisotopes are summarized. A new record for continuous beam power on a production target, 36 kw for 5 hr, was achieved. The design of a beam-deflector system for the 86-in. cyclotron has been completed, and several of the components have been fabricated ; a shutdown for installation is scheduled for October 8. The deflected N+++ beam of the 63-in. cyclotron was used in a study of the gain and loss of electrons by nitrogen lens passing through thin foils, and the equilibrium charge distribution of lens as a function of energy was thus obtained. The excitation functions were measured for nitrogen-induced reactions on both nitrogen and oxygen. Assembly restrictions of the prepared 114-in. heavy-particle cyclotron …