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Hedgehog signaling is involved in acquired resistance to KRASG12C inhibitors in lung cancer cells
Article states that although KRASG12C inhibitors have shown promising activity in lung adenocarcinomas harboring KRASG12C, acquired resistance to these therapies eventually occurs in most patients. The authors report that the hedgehog signal is induced by KRASG12C inhibitors and mediates KRAS re-expression in cancer cells treated with a KRASG12C inhibitor.
Date:
January 16, 2024
Creator:
Lee, Chaeyoung; Yi, Jawoon; Park, Jihwan; Ahn, Byungyong; Won, Young-Wook; Jeon, JiHeung et al.
System:
The UNT Digital Library
Development and Utilization of Bridge Data of the United States for Predicting Deck Condition Rating Using Random Forest, XGBoost, and Artificial Neural Network
Article describes how accurately predicting the condition rating of a bridge deck is crucial for effective maintenance and repair planning. This study aims to assess the effectiveness of these algorithms for deck condition rating prediction at the national level.
Date:
January 16, 2024
Creator:
Fard, Fariba & Fard, Fereshteh Sadeghi Naieni
System:
The UNT Digital Library