This report discusses U.S. sanctions against Iran and the 2016 Joint Comprehensive Plan of Action (JCPOA) nuclear agreement which led to the lifting of sanctions based on nuclear proliferation in Iran. The bulk of the report outlines the various sanctions against Iran and their current implementation status, international efforts to bring about compliance, and their effects. Recent discussions regarding President's Trump announcement that the U.S. was decertifying the nuclear agreement and the possibility of reinstating certain sanctions are also discussed.