"This symposium is concerned with the basic aspects of radiation effects. When we turn to the genetic effects of radiation in mammals, there are so few aspects on which there is any information that the problem of sorting out the fundamental findings has hardly arisen. In this paper it will, therefore, be possible to survey most of what is known and pass on to a consideration of what is needed next. Since one of the purposes of this symposium is an interchange of views between investigators in different fields, an attempt will be made to avoid technical details. Among the practical needs in mammalian radiation genetics is a pressing one for more data on which to base estimates of the genetic hazards of radiation in man. The present paper will be concerned largely with this problem. Our own work is directed primarily in this direction, our objective being to uncover some of the basic facts in at least one mammal-the mouse. Before discussing the experimental work, however, it seems desirable to consider some of the general features of the genetic hazard of radiation."

From abstract: "A full-scale, always-safe, metal dissolver for Experimental Breeder Reactor fuel was designed, built, and installed for test operation. It was found that the dissolver operated satisfactorily, and feasible operating procedures were established for the dissolution of bare, or jacketed, EBR slugs. Minor modifications of the dissolver design have been required to accomodate [sic] a modified EBR slug, but it is believed that this will not significantly affect its operating characteristics."