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NSC109268 potentiates cisplatin-induced cell death in a p53-independent manner
This article's study endeavors to determine if p53 is responsible for cisplatin sensitization by NSC109268. Results have implications for sensitivity of ovarian cancer cells to cisplatin independent of p53.
Date:
October 5, 2010
Creator:
Shankar, Eswar; Basu, Chandreyi; Adkins, Brett; Siede, Wolfram & Basu, Alakananda
System:
The UNT Digital Library
Sarcoidosis and Its Splenic Wonder: A Rare Case of Isolated Splenic Sarcoidosis
This article is a case study discussing a case of a 40-year-old female with isolated splenic sarcoidosis found to have isolated splenomegaly with multiple hypodense splenic lesions and no other multisystem involvement. Isolated splenomegaly is very rare and an uncommon presentation of sarcoidosis. This case is clinically challenging because of the extensive differential diagnosis. The authors conclude that sarcoidosis of the spleen, although rare, should be considered in the differential diagnosis of the patients presenting with systemic symptoms and splenomegaly.
Date:
November 5, 2018
Creator:
Jhaveri, Khushali & Surani, Salim R.
System:
The UNT Digital Library
The Implications of Cancer Stem Cells for Cancer Therapy
This review summarizes the characteristics, evidences and development of CSCs, as well as implications and challenges for cancer treatment. Surgery, radiotherapy and chemotherapy are universally recognized as the most effective anti-cancer therapies. Recent studies have showed that cancer stem cells (CSCs), a small subpopulation of tumor cells, can generate bulk populations of nontumorigenic cancer cell progeny through the self-renewal and differentiation processes.
Date:
December 5, 2012
Creator:
Jiang, Wenjing; Peng, Jianhua; Zhang, Yue; Cho, William C. S. & Jin, Kunlin
System:
The UNT Digital Library
Kynurenic Acid Protects Against Ischemia/Reperfusion-Induced Retinal Ganglion Cell Death in Mice
Study investigated the role of the neuroprotective kynurenic acid (KYNA) in RGC death against retinal ischemia/reperfusion (I/R) injury.
Date:
March 5, 2020
Creator:
Nahomi, Rooban B.; Nam, Mi-Hyun; Rankenberg, Johanna; Rakete, Stefan; Houck, Julie A.; Johnson, Ginger C. et al.
System:
The UNT Digital Library
Intermittent Hypoxic Conditioning Alleviates Post-Traumatic Stress Disorder-Induced Damage and Dysfunction of Rat Visceral Organs and Brain
Study examines intermittent hypoxic conditioning's (IHC) ability to alleviate harmful PTSD effects on a rat's heart, liver, and brain.
Date:
January 5, 2020
Creator:
Manukhina, Eugenia B.; Tseilikman, Vadim E.; Karpenko, Marina N.; Pestereva, Nina S.; Tseilikman, Olga B.; Komelkova, Maria V. et al.
System:
The UNT Digital Library