The aim of this project was to develop Synthetic High-Affinity Ligands (SHALs), which bind with high affinity and specificity to proteins of interest for national security and cancer therapy applications. The aim of producing synthetic ligands for sensory devices as an alternative to antibody-based detection assays and therapeutic agents is to overcome the drawbacks associated with antibody-based in next-generation sensors and systems. The focus area of the project was the chemical synthesis of the SHALs. The project concentrated on two different protein targets. (a) The C fragment of tetanus and botulinum toxin, potential biowarfare agents. A SHAL for tetanus or botulinum toxin would be incorporated into a sensory device for the toxins. (b) HLA-DR10, a protein found in high abundance on the surface of Non-Hodgkins Lymphoma. A SHAL specific to a tumor marker, labeled with a radionuclide, would enable the targeted delivery of radiation therapy to metastatic disease. The technical approach used to develop a SHAL for each protein target will be described in more detail below. However, in general, the development of a SHAL requires a combination of computational modeling techniques, modern nuclear magnetic resonance spectroscopy (NMR) and synthetic chemistry.

The 9/11 attacks were part of Al Qaeda’s strategy to disrupt Western economies and impose both direct and secondary costs on the United States and other nations. The immediate costs were the physical damage, loss of lives and earnings, slower world economic growth, and capital losses on stock markets. Indirect costs include higher insurance and shipping fees, diversion of time and resources away from enhancing productivity to protecting and insuring property, public loss of confidence, and reduced demand for travel and tourism. In a broader sense, the 9/11 attacks led to the invasions and occupations of Afghanistan and Iraq (and the Global War on Terrorism) and perhaps emboldened terrorists to attack in Bali, Spain, Morocco, and Saudi Arabia. A policy question for Congress is how to evaluate the costs and benefits of further spending to counter terrorism and its economic impact.

Volume 2 provides estimated chemical and radionuclide inventories of sludge currently stored within the Hanford Site's 105-K Basin This volume also provides estimated chemical and radionuclide inventories for the sludge streams expected to be generated during Spent Nuclear Fuel (SNF) Project activities.

The CTFM Subproject of the SNF Project has prepared an ABU checklist per SNF Administrative Procedure (AP) CS-6-019. This checklist identifies the essential documentation needed to operate and maintain the 105 KW CTFM/CLS Structures, Systems, and Components (SSCs) when ownership is transferred from the CTFM Subproject to K Basins Operations. Approval of this supporting document demonstrates an agreement by the approvers as to the documentation required at turnover.

Policymakers rely on transportation statistics, including data on personal travel behavior, to formulate strategic transportation policies and to improve the safety and efficiency of the U.S. transportation system. Data on personal travel trends are needed to examine the reliability, efficiency, capacity, and flexibility of the Nation's transportation system to meet current demands and accommodate future demands; to assess the feasibility and efficiency of alternative congestion-alleviating technologies (e.g., high-speed rail, magnetically levitated trains, intelligent vehicle and highway systems); to evaluate the merits of alternative transportation investment programs; and to assess the energy-use and air-quality impacts of various policies. To address these data needs, the Department of Transportation (DOT) initiated an effort in 1969 to collect detailed data on personal travel. The 1969 survey was the first Nationwide Personal Transportation Survey (NPTS). The survey was conducted again in 1977, 1983, 1990, and 1995. The 1995 survey was cosponsored by four DOT agencies: Federal Highway Administration (FHWA), Bureau of Transportation Statistics (BTS), Federal Transit Administration (FTA), and National Highway Traffic Safety Administration (NHTSA). The primary objective of the survey was to collect trip-based data on the nature and characteristics of personal travel. Commercial and institutional travel were not part of the survey.

This report provides a detailed geographic analysis of two specific topics affecting the residential sector. First, we performed an analysis of new construction market trends using annual building permit data. We report summarized tables and national maps to help illustrate market conditions. Second, we performed a detailed geographic analysis of the housing finance market. We analyzed mortgage application data to provide citable statistics and detailed geographic summarization of the residential housing picture in the US for each year in the 1996-2004 period. The databases were linked to geographic information system tools to provide various map series detailing the results geographically. Looking at these results geographically may suggest potential new markets for TD programs addressing the residential sector that have not been considered previously. For example, we show which lenders affect which regions and which income or mortgage product classes. These results also highlight the issue of housing affordability. Energy efficiency R&D programs focused on developing new technology for the residential sector must be conscious of the costs of products resulting from research that will eventually impact the home owner or new home buyer. Results indicate that home values as a proportion of median family income in Building America communities are …

Annual Illness and Injury Surveillance Program report for 2003 for the Pantex Plant. DOE is commited to assuring the health and safety of its workers. This includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. The IISP monitors illnesses and health conditions that result in an absence of workdays, occupational injuries and illnesses, and disabilities and deaths among current workers.

Annual Illness and Injury Surveillance Program report for 2003 for the Savannah River Site. DOE is commitment to assuring the health and safety of its workers includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. The report monitors illnesses and health conditions that result in an absence of workdays, occupational injuries and illnesses, and disabilities and deaths among current workers.

From Summary: This report briefly summarizes the events that occurred and the issues, they raised in regards to violations of state laws, against Marsh & McClennan Companies and Marsh, Inc, which the Attorney General of the Sate of New York filling a civil law suit.

First part of the final report of the 2005 Defense Base Closure and Realignment Commission (BRAC) analyzing the recommendations made by the U.S. Department of Defense (DOD) regarding 160 military installations. This volume includes the executive summary for the project and four chapters regarding the Commission's work: 1. Commission Findings & Recommendations, 2. Issues for Further Consideration, 3. Previous Experience with Base Closures, and 4. The 2005 BRAC Process. Additional material is published in the appendices (Volume 2).

Since the last report, there have been no material changes in the detector element inventories in buildings 151 and 332 at LLNL. Stable element inventories in building 151 have remained stable since the inventory in September 2005. For the first time in many years, Stockpile Radiochemistry personnel viewed radioactive tracer materials that reside in building 332. A list of LLNL tracers and locations are available under separate cover. Despite the recent NNSA agreement to retain 2.8 kg of {sup 233}U for programmatic purposes, we have yet to identify a location that is appropriate and will accept the material. A recent visit to the Oak Ridge National Laboratory (ORNL) in September 2006 revealed nearly 190 kg of material with very high {sup 233}U content scheduled for down-blending in various chemical and isotopic forms. The chemical form, isotopic and chemical purities of this material were such that roughly 150 kg of the material was of comparable composition to the desired tracer package material and would be acceptable for use in an underground test, should the US even conduct such a test. Efforts continue to remove 2.8 kg of material from the down-blend cue and reserve it for the Test Readiness mission.

The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence of workdays, occupational injuries and illnesses, and disabilities and deaths among current workers.

The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence of workdays, occupational injuries and illnesses, and disabilities and deaths among current workers.

This report provides an overview of key actions taken and authorities invoked by WHO and the U.S. government. First, it discusses the WHO process to determine the phase of a threatened or emerging flu pandemic and touches on a number of related issues. The report then examines actions taken by the Departments of Homeland Security and Health and Human Services and provides information about appropriations and funding for pandemic flu activities.

This report summarizes the reauthorized Elementary and Secondary Education Act (ESEA) which contains the 21st Century Community Learning Centers (21st CCLC) program. The report covers the history of the ESEA as well as what is new in the reauthorization. Moreover, the report includes how grants are selected now, and the new focus of the program which is now exclusively for after-school-hours activities for children.

Nozzle geomtry, pilot injection and post injection effects were studied.

This project consists of two activities. Task A, Simulations and Measurements, combines all the material model development and associated numerical work with the materials-oriented experimental activities. The goal of this effort is to provide an improved understanding of dynamic material properties and to provide accurate numerical representations of those properties for use in analysis codes. Task B, ALE3D Development, involves general development activities in the ALE3D code with the focus of improving simulation capabilities for problems of mutual interest to DoD and DOE. Emphasis is on problems involving multi-phase flow, blast loading of structures and system safety/vulnerability studies.

The atomic-scale processes that control the formation of carbon deposits on Ni catalysts in reforming applications are poorly understood. Ab initio Density Functional Theory calculations have been used to examine several key elementary steps in the complex network of chemical reactions that precedes carbon formation on practical catalysts. Attention has been focused on the disproportionation of CO. A comparative study of this reaction on flat and stepped crystal planes of Ni has provided the first direct evidence that surface carbon formation is driven by elementary reactions occurring at defect sites on Ni catalysts. The adsorption and diffusion of atomic H on several flat and stepped Ni surfaces has also been characterized experimentally.

The primary focus of this issue brief is legislative action with respect to abortion. However, discussion of those legislative proposals necessarily involves a brief discussion of the leading U.S. Supreme Court decisions concerning a woman’s right to choose whether to terminate her pregnancy. For a more detailed discussion of the relevant case law, see CRS Report 95-724, Abortion Law Development: A Brief Overview.

This Technical Memorandum (TM) summarizes the accelerator and experiment operations for the period FY 2001 through FY 2003. The plan is to have an annual TM to gather such information in one place. In this case, the information concerns the startup of Run II at the Tevatron Collider and the beginning of the MiniBooNE neutrino experiment. While the focus is on the FY 2003 efforts, this document includes summaries of the earlier years where available for completeness.

This Acceptance Test Procedure (ATP) provides for the inspection and testing of the new Pumping Instrumentation and Control (PIC) skid designed as ''U''. The ATP will be performed after the construction of the PIC skid in the fabrication shop.

The Constitution of the United States makes no specific allowance for any one of the co-equal branches to have access to information held by the others and contains no provision expressly establishing a procedure for, or a right of, public access to government information. Nonetheless, Congress has legislated various public access laws. These include two records access statutes — the Freedom of Information Act and the Privacy Act — and two meetings access statutes — the Federal Advisory Committee Act and the Government in the Sunshine Act. This report provides background on the issue of government transparency and examines relevant litigation.

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The power point presentation for the Natural Gas Technologies II Conference held on February 8-11, 2004 in Phoenix AZ, published the presentations made at the conference, therefore required all presenters to submit their presentation prior to November 2003. However in the remainder of year, significant new test data became available which were incorporated in the actual presentation made at the Natural Gas Technologies II Conference. The 6th progress report presents the updated actual slide show used during the paper presentation by Richard Guiler.