Energy correlations in transitions from the bound state to the three-body continuum of Borromean halo nuclei are considered. A core+n+n three-body cluster model which reproduces experimentally known properties of {sup 6}He and {sup 11}Li has been used to study low-lying resonances and soft modes. The analysis of the correlated responses in {sup 6}He shows that in the case of the narrow three-body 2{sub 1}{sup +} resonance the transition energy correlations are the same as in the intrinsic correlated structure in 3 {yields} 3 scattering. They differ significantly for wide 2{sub 2}{sup +}, 1{sub 1}{sup +} resonances, and also for the soft dipole and monopole modes, where, due to the transition operators, the intertwining of the ground state and the three-body continuum plays a significant role.

The author begins with a brief review of the goals of the EMMA experiment. He then describe two stages of EMMA commissioning. The first stage is simply to get the beam to circulate a full turn in the ring, and is done only once during the course of the experiment. The second stage will be repeated several times, at least once for each lattice configuration, and involves two parts: setting the required values for the machine parameters, and determining the tunes and time of flight as a function of energy.

Annual Illness and Injury Surveillance Program report for 2003 for the Pantex Plant. DOE is commited to assuring the health and safety of its workers. This includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. The IISP monitors illnesses and health conditions that result in an absence of workdays, occupational injuries and illnesses, and disabilities and deaths among current workers.

Currently, a combination of technologies is typically required to assess the malignancy of cancer cells. These methods often lack the specificity and sensitivity necessary for early, accurate diagnosis. Here we demonstrate using clinical samples the application of laser trapping Raman spectroscopy as a novel approach that provides intrinsic biochemical markers for the noninvasive detection of individual cancer cells. The Raman spectra of live, hematopoietic cells provide reliable molecular fingerprints that reflect their biochemical composition and biology. Populations of normal T and B lymphocytes from four healthy individuals, and cells from three leukemia patients were analyzed, and multiple intrinsic Raman markers associated with DNA and protein vibrational modes have been identified that exhibit excellent discriminating power for cancer cell identification. A combination of two multivariate statistical methods, principal component analysis (PCA) and linear discriminant analysis (LDA), was used to confirm the significance of these markers for identifying cancer cells and classifying the data. The results indicate that, on average, 95% of the normal cells and 90% of the patient cells were accurately classified into their respective cell types. We also provide evidence that these markers are unique to cancer cells and not purely a function of differences in their cellular activation.

This presentation describes the tools and services provided by the National Atmospheric Release Advisory Center (NARAC) at Lawrence Livermore National Laboratory (LLNL) for modeling the impacts of airborne hazardous materials. NARAC provides atmospheric plume modeling tools and services for chemical, biological, radiological, and nuclear airborne hazards. NARAC can simulate downwind effects from a variety of scenarios, including fires, industrial and transportation accidents, radiation dispersal device explosions, hazardous material spills, sprayers, nuclear power plant accidents, and nuclear detonations. NARAC collaborates on radiological dispersion source terms and effects models with Sandia National Laboratories and the U.S. Nuclear Regulatory Commission. NARAC was designated the interim provider of capabilities for the Department of Homeland Security's Interagency Modeling and Atmospheric Assessment Center by the Homeland Security Council in April 2004. The NARAC suite of software tools include simple stand-alone, local-scale plume modeling tools for end-user's computers, and Web- and Internet-based software to access advanced modeling tools and expert analyses from the national center at LLNL. Initial automated, 3-D predictions of plume exposure limits and protective action guidelines for emergency responders and managers are available from the center in 5-10 minutes. These can be followed immediately by quality-assured, refined analyses by 24 x 7 on-duty or …

We present a measurement of the K-shell spectrum of He-like through Be-like praseodymium ions trapped in the Livermore SuperEBIT electron beam ion trap using a bismuth absorber pixel on the XRS/EBIT microcalorimeter. This measurement is the first of its kind where the n=2 to n=1 transitions of the various charge states are spectroscopically resolved. The measured transition energies are compared with theoretical calculations from several atomic codes.

The epidemiological and economic modeling of poultry diseases requires knowing the size, location, and operational type of each poultry type operation within the US. At the present time, the only national database of poultry operations that is available to the general public is the USDA's 2002 Agricultural Census data, published by the National Agricultural Statistics Service, herein referred to as the 'NASS data'. The NASS data provides census data at the county level on poultry operations for various operation types (i.e., layers, broilers, turkeys, ducks, geese). However, the number of farms and sizes of farms for the various types are not independent since some facilities have more than one type of operation. Furthermore, some data on the number of birds represents the number sold, which does not represent the number of birds present at any given time. In addition, any data tabulated by NASS that could identify numbers of birds or other data reported by an individual respondent is suppressed by NASS and coded with a 'D'. To be useful for epidemiological and economic modeling, the NASS data must be converted into a unique set of facility types (farms having similar operational characteristics). The unique set must not double count …

I develop a formulation for Hamiltonian dynamics in an accelerator with magnets whose edges follow a spiral. I demonstrate using this Hamiltonian that a spiral FFAG can be made perfectly 'scaling'. I examine the effect of tilting an RF cavity with respect a radial line from the center of the machine, potentially with a different angle than the spiral of the magnets.

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The cyclotide MCoTI-II is a powerful trypsin inhibitor recently isolated from the seeds of Momordica cochinchinensis, a plant member of cucurbitaceae family. We report for the first time the in vivo biosynthesis of natively-folded MCoTI-II inside live E. coli cells. Our biomimetic approach involves the intracellular backbone cyclization of a linear cyclotide-intein fusion precursor mediated by a modified protein splicing domain. The cyclized peptide then spontaneously folds into its native conformation. The use of genetically engineered E. coli cells containing mutations in the glutathione and thioredoxin reductase genes considerably improves the production of folded MCoTI-II in vivo. Biochemical and structural characterization of the recombinant MCoTI-II confirmed its identity. Biosynthetic access to correctly-folded cyclotides allows the possibility of generating cell-based combinatorial libraries that can be screened inside living cells for their ability to modulate or inhibit cellular processes.

These results are from the continuing Lattice Quantum Chromodynamics runs on BG/L. These results are from the Ferrenberg-Swendsen analysis [?] of the combined data from LLNL and NYBlue BG/L runs for 32{sup 3} x 8 runs with the p4rhmc v2.0 QMP-MPI.X (semi-optimized p4 code using qmp over mpi). The jobs include beta values ranging from 3.525 to 3.535 with an alternate analysis extending to 3.540. The NYBlue data sets are from 9k trajectories from Oct 2007, and the LLNL data are from two independent streams of {approx}5k each, taking from the July 2007 runs. The following outputs are produced by the fs-2+1-chiub.c program. All outputs have had checksums produced by addCks.pl and checked by the checkCks.pl perl script after scanning.

This letter serves as the post-closure monitoring letter report for the above Corrective Action Unit (CAU) for calendar year 2006. CAU 91 is inspected every six months. The first inspection was conducted on March 23, 2006, and the second inspection was conducted on September 19, 2006. All access roads, fences, gates, and signs were in excellent condition. No settling, cracking, or erosion was observed on the cover, and the use restriction had been maintained. No issues were identified, and no corrective actions were needed. The post-closure inspection checklists for CAU 91 are attached. Photographs and fields notes taken during site inspections are maintained in the project files.

"World best practice" energy intensity values, representingthe most energy-efficient processes that are in commercial use in atleast one location worldwide, are provided for the production of iron andsteel, aluminium, cement, pulp and paper, ammonia, and ethylene. Energyintensity is expressed in energy use per physical unit of output for eachof these commodities; most commonly these are expressed in metric tonnes(t). The energy intensity values are provided by major energy-consumingprocesses for each industrial sector to allow comparisons at the processlevel. Energy values are provided for final energy, defined as the energyused at the production facility as well as for primary energy, defined asthe energy used at the production facility as well as the energy used toproduce the electricity consumed at the facility. The "best practice"figures for energy consumption provided in this report should beconsidered as indicative, as these may depend strongly on the materialinputs.

Ionization efficiency studies for high charge state xenon ions using a calibrated gas leak are presented. A 75% enriched {sup 129}Xe gas leak with a gas flow equivalent to 5.11p{mu}A was used in all the measurements. The experiments were performed at the VENUS (Versatile ECR ion source for Nuclear Science) ion source for 18 GHz, 28 GHz and double frequency operation. Overall, total ionization efficiencies close to 100% and ionization efficiencies into a single charge state up to 22% were measured. The influence of the biased disk on the ionization efficiency was studied and the results were somewhat surprising. When the biased disk was removed from the plasma chamber, the ionization efficiency was dramatically reduced for single frequency operation. However, using double frequency heating the ionization efficiencies achieved without the biased disk almost matched the ionization efficiencies achieved with the biased probe. In addition, we have studied the influence of the support gas on the charge state distribution of the xenon ions. Either pure oxygen or a mixture of oxygen and helium were used as support gases. The addition of a small amount of helium can increase the ionization efficiency into a single charge state by narrowing the charge state …

A study of the laser-plasma interaction processes in multiple-ion species plasmas has been performed in plasmas that are created to emulate the plasma conditions in indirect drive inertial confinement fusion targets. Gas-filled hohlraums with densities of xe22/cc are heated to Te=3keV and backscattered laser light is measured by a suite of absolutely calibrated backscatter diagnostics. Ion Landau damping is increased by adding hydrogen to the CO2/CF4 gas fill. We find that the backscatter from stimulated Brillouin scattering is reduced is monotonically reduced with increasing damping, demonstrating that Landau damping is the controlling damping mechanism in ICF relevant high-electron temperature plasmas. The reduction in backscatter is accompanied by a comparable increase in both transmission of a probe beam and an increased hohlraum radiation temperature, showing that multiple-ion species plasmas improve the overall hohlraum energetics/performance. Comparison of the experimental data to linear gain calculations as well as detailed full-scale 3D laser-plasma interaction simulations show quantitative agreement. Our findings confirm the importance of Landau damping in controlling backscatter from high-electron temperature hohlraum plasmas and have lead to the inclusion of multi-ion species plasmas in the hohlraum point design for upcoming ignition campaigns at the National Ignition Facility.

Static {sup 1}H Multiple Quantum Nuclear Magnetic Resonance (MQ NMR) has recently been shown to provide detailed insight into the network structure of pristine silicon based polymer systems. The MQ NMR method characterizes the residual dipolar couplings of the silicon chains that depend on the average molecular weight between physical or chemical constraints. Recently, we have employed MQ NMR methods to characterize the changes in network structure in a series of complex silicone materials subject to numerous degradation mechanisms, including thermal, radiative, and desiccative. For thermal degradation, MQ NMR shows that a combination of crosslinking due to post-curing reactions as well as random chain scissioning reactions occurs. For radiative degradation, the primary mechanisms are via crosslinking both in the network and at the interface between the polymer and the inorganic filler. For samples stored in highly desiccating environments, MQ NMR shows that the average segmental dynamics are slowed due to increased interactions between the filler and the network polymer chains.

Each of the hypothetical accident test cases for the 9977 prototypes was included in the battery of finite element structural analyses performed for the package. Comparison of the experimental and analytical results provides a means of confirming that the analytical model correctly represents the physical behavior of the package. The ability of the analytical model to correctly predict the performance of the foam overpack material for the crush test is of particular interest. The dissipation of energy in the crushing process determines the deceleration of the package upon impact and the duration of the impact. In addition, if the analytical model correctly models the foam behavior, the predicted deformation of the package will match that measured on the test articles. This study compares the deformations of the test packages with the analytical predictions. In addition, the impact acceleration and impact duration for the test articles are compared with those predicted by the analyses.

Many experimental approaches in biology and biophysics, as well as applications in diagnosis and drug discovery, require proteins to be immobilized on solid supports. Protein microarrays, for example, provide a high-throughput format to study biomolecular interactions. The technique employed for protein immobilization is a key to the success of these applications. Recent biochemical developments are allowing, for the first time, the selective and traceless immobilization of proteins generated by cell-free systems without the need for purification and/or reconcentration prior to the immobilization step.

Point design ignition capsules designed for the National Ignition Facility (NIF) currently use an x-ray-driven Be(Cu) ablator to compress the DT fuel. Ignition specifications require that the mass of unablated Be(Cu), called residual mass, be known to within 1% of the initial ablator mass when the fuel reaches peak velocity. The specifications also require that the implosion bang time, a surrogate measurement for implosion velocity, be known to +/- 50 ps RMS. These specifications guard against several capsule failure modes associated with low implosion velocity or low residual mass. Experiments designed to measure and to tune experimentally the amount of residual mass are being developed as part of the National Ignition Campaign (NIC). Tuning adjustments of the residual mass and peak velocity can be achieved using capsule and laser parameters. We currently plan to measure the residual mass using streaked radiographic imaging of surrogate tuning capsules. Alternative techniques to measure residual mass using activated Cu debris collection and proton spectrometry have also been developed. These developing techniques, together with bang time measurements, will allow us to tune ignition capsules to meet NIC specs.

The purpose of this annual monitoring report is to evaluate the conditions of and identify trends for groundwater beneath the ERDF and to report leachate results in fulfillment of the requirements specified in the ERDF ROD.

Unlike the classical Yersinia pestis strains, members of an atypical group of Y. pestis from Central Asia, denominated Y. pestis subspecies caucasica (also known as one of several pestoides types), are distinguished by a number of characteristics including their ability to ferment rhamnose and melibiose, their lacking the small plasmid encoding the plasminogen activator (pla) and pesticin, and their exceptionally large variants of the virulence plasmid pMT (encoding murine toxin and capsular antigen). We have obtained the entire genome sequence of Y. pestis Pestoides F, an isolate from the former Soviet Union that has enabled us to carryout a comprehensive genome-wide comparison of this organism's genomic content against the six published sequences of Y. pestis and their Y. pseudotuberculosis ancestor. Based on classical glycerol fermentation (+ve) and nitrate reduction (+ve) Y. pestis Pestoides F is an isolate that belongs to the biovar antiqua. This strain is unusual in other characteristics such as the fact that it carries a non-consensus V antigen (lcrV) sequence, and that unlike other Pla{sup -} strains, Pestoides F retains virulence by the parenteral and aerosol routes. The chromosome of Pestoides F is 4,517,345 bp in size comprising some 3,936 predicted coding sequences, while its pCD and …

We consider orientifold field theories (i.e. SU(N) Yang-Mills theories with fermions in the two-index symmetric or antisymmetric representations) on R{sub 3} x S{sub 1} where the compact dimension can be either temporal or spatial. These theories are planar equivalent to supersymmetric Yang-Mills. The latter has Z{sub N} center symmetry. The famous Polyakov criterion establishing confinement-deconfinement phase transition as that from Z{sub N} symmetric to Z{sub N} broken phase applies. At the Lagrangian level the orientifold theories have at most a Z{sub 2} center. We discuss how the full Z{sub N} center symmetry dynamically emerges in the orientifold theories in the limit N {yields} {infinity}. In the confining phase the manifestation of this enhancement is the existence of stable k-strings in the large-N limit of the orientifold theories. These strings are identical to those of supersymmetric Yang-Mills theories. We argue that critical temperatures (and other features) of the confinement-deconfinement phase transition are the same in the orientifold daughters and their supersymmetric parent up to 1/N corrections. We also discuss the Abelian and non-Abelian confining regimes of four-dimensional QCD-like theories.

Many complex systems can be represented and analyzed as networks, and examples that have benefited from this approach span the natural sciences. For instance, we now know that systems as disparate as the World-Wide Web, the Internet, scientific collaborations, food webs, protein interactions and metabolism all have common features in their organization, the most salient of which are their scale-free connectivity distributions and their small-world behavior. The recent availability of large scale datasets that span the proteome or metabolome of an organism have made it possible to elucidate some of the organizational principles and rules that govern their function, robustness and evolution. We expect that combining the currently separate layers of information from gene regulatory-, signal transduction-, protein interaction- and metabolic networks will dramatically enhance our understanding of cellular function and dynamics.

Reactivity transients have been analyzed with an updated RELAPS-3D (ver. 2.4.2) system model of the pin core design for the 2400MWt gas-cooled fast reactor (GCFR). Additional reactivity parameters were incorporated in the RELAP5 point-kinetics model to account for reactivity feedbacks due to axial and radial expansion of the core, fuel temperature changes (Doppler effect), and pressure changes (helium density changes). Three reactivity transients without scram were analyzed and the incidents were initiated respectively by reactivity ramp, loss of load, and depressurization. During the course of the analysis the turbine bypass model for the power conversion unit (PCU) was revised to enable a better utilization of forced flow cooling after the PCU is tripped. The analysis of the reactivity transients demonstrates the significant impact of the PCU on system pressure and core flow. Results from the modified turbine bypass model suggest a success path for the GCFR to mitigate reactivity transients without scram.