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25,827 Matching Results
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Development and Characterization of Compliant Bioelectronic Devices for Gastrointestinal Stimulation
In this research, we aimed to develop thin-film devices on a polymer substrate and an alternative 3D-printed device with macroelectrodes for treating gastrointestinal (GI) conditions. First, the fabrication of thin-film devices was demonstrated on a softening thiol-ene/acrylate polymer utilizing titanium nitride (TiN) as electrode material. This was achieved by utilizing cleanroom fabrication processes such as photolithography, wet and dry etching. The functionality of the device was shown by performing electrochemical characterization tests, mainly cyclic voltammetry, electrochemical impedance spectroscopy, and voltage transient. We synthesized a novel thiol-ene/acrylate polymer based on 1,3,5-triallyl-1,3,5-triazine-2,4,6(1H,3H,5H)-trione (TATATO), trimethylolpropanetris (3-mercaptopropionate) (TMTMP), and polyethylene glycol diacrylate (PEGDA). We show that this stretchable shape memory polymer substrate is well suited for cleanroom processes. Finally, for the high throughput of the wearable devices with electrodes size 10 mm in diameter, we implemented single electrode fabrication using printed circuit boards (PCBs) and depositing gold (Au) and TiN on the plated side of PCBs utilizing the sputtering tool. This step was followed by the assembly of those single electrodes on the flexible 3D printed device. We showed that the TiN electrode material performed better in terms of charge storage capacity and charge injection capacity than the widely used stainless steel electrode material …
Date:
December 2023
Creator:
Chitrakar, Chandani
System:
The UNT Digital Library
Development and Preliminary Validation of the Comprehensive Trauma and Stressors Checklist
To assess a wide range of stressors and traumas, we developed a trauma and stressors exposure checklist for adults to capture a wide variety of potential trauma exposure. This study details the extensive development and validation process of the Comprehensive Trauma and Stressors Checklist (CTSC). Study 1 consisted of item pool generation, review of existing trauma measures, content analysis, and expert review and input. Study 2 analyzed reliability and validity of the updated checklist. Participants were recruited from college and community samples (N = 200) and completed the CTSC along with five additional measures. The CTSC demonstrated high internal consistency (α =.96). Good temporal stability was established with a subset of participants (n = 28) who completed the survey twice for test-retest reliability (r = 0.86, p < .001). Significant correlations between scores on the CTSC and the Stressful Life Events Screening Questionnaire, Life Events Checklist for the DSM-5, Intersectional Discrimination Index, and Spiritual Abuse Questionnaire are evidence of strong convergent validity. Finally, the lack of significant correlations between CTSC scores and theoretically unrelated constructs supported the discriminant validity of the CTSC. This study provides preliminary evidence that the CTSC is a reliable and valid measure of exposure to traumas …
Date:
December 2023
Creator:
Kemble, Lauren Alicia
System:
The UNT Digital Library
Directing Transition Metal Catalysis of Second and Third Row Metals through Ligand Design
Ligand design is important due to a ligand's ability to tune properties of the transition metals, such as catalytic activity and selectivity. Gold(I) catalysts can be directly impacted by ligands electronically as well as with steric bulk when undergoing enantioselective and regioselective reactions. In the dissertation, a series of gold(I) acyclic diaminocarbenes were synthesized and used to explore the 1,6 enyne cyclization/hydroarylation. The use of metal templated synthesis of the gold(I) acyclic diaminocarbenes allowed for the gradual increase in steric bulk of the catalysts. In the end, it was shown that electronics play the major role in the regioselectivity for the 1,6 enyne cyclization/hydroarylation but localized steric bulk can control the catalytic reaction if placed strategically. Cross-coupling reactions used to form carbon-carbon or carbon-heteroatom bonds are important in the production of pharmaceutical chemicals on a large scale. Iron, an extremely cheap and earth abundant first row transition metal, has had some success in cross-coupling reactions. Iron does not go through the same catalytic cycle for cross-coupling as most transition metals, the most common of which is palladium. In the dissertation, a ligand was developed to induce Iron to undergo the same cycle as palladium. In addition, the same ligand was …
Date:
December 2023
Creator:
Nguyen, John
System:
The UNT Digital Library
The Effect of Developmental Hypoxia on Cardiac Physiology in Three Species: Alligator mississippiensis, Chelydra serpentina, and Danio rerio
In this dissertation, I explored the effects of developmental hypoxia on heart contractility in three separate species of ectotherms: the common snapping turtle (Chelydra serpentina), the American alligator (Alligator mississippiensis), and the zebrafish (Danio rerio). I began with the common snapping turtle and tested whether the utilization of the sarcoplasmic reticulum was altered in response to developmental hypoxia. In the next two chapters, developmental hypoxia of the American alligator was explored studying how the cardiac tissue was affected, specifically in physiological stressors, sarcoplasmic reticulum utilization and sensitivity to pharmacological increases in contractility. The last chapter explored how zebrafish heart contractility was altered in response to chronic hypoxia from egg to adult. Findings from these chapters suggest that while developmental hypoxia did alter cardiac contractility, it did not alter the response of the heart to physiological stressors such as increased heart rate or under hypoxia. Overall, these findings contribute to increasing the current understanding of how developmental hypoxia alters the cardiovascular system but with an emphasis on the cardiac tissue level.
Date:
December 2023
Creator:
Smith, Brandt Ragan
System:
The UNT Digital Library
The Effect of Restructuring of Peer Firms on Investment
Firms' operational restructuring involves information relevant to strategic choices as well as future demand and cost conditions. This study examines the relationship between peer firms' restructuring and a company's responsiveness to its growth opportunities. Peer firm restructuring can increase uncertainty with respect to a company's payoffs regarding its investment projects, leading to decreased responsiveness to growth opportunities. Using a large sample of public companies during 2006–2020, I find that peer firms' restructuring is negatively associated with the responsiveness of capital expenditures (Capex) to growth opportunities. The results suggest that peer firms' restructuring activities provide information about a company's investment projects above and beyond industry shocks reflected in changes in industry sales. Furthermore, these associations are moderated by industry competition. The negative effects of peer firms' restructuring on Capex sensitivity are the strongest in high-competition industries.
Date:
December 2023
Creator:
Kim, Hojoong
System:
The UNT Digital Library
Effects of Impaired Verbal Abilities on Miranda Comprehension and Reasoning: "Do You Understand Your Rights?"
In Miranda v. Arizona (1966), the Supreme Court of the United States required that custodial arrestees be informed of their constitutional and continuous rights to silence and to legal counsel. Moreover, the ruling mandated that waivers be considered valid only if they were made knowingly, intelligently, and voluntarily. However, in the decades that followed, evidence from both caselaw and empirical scholarship clarified that, for many vulnerable populations, these rights are in jeopardy. Among these vulnerable populations, those with limited cognitive capacities (LCCs) have been functionally excluded from research which primarily focused on persons with intellectual disabilities. This thesis offers a novel exploration of the role of specific cognitive impairments on Miranda comprehension and reasoning, with a focus on verbal intelligence (VIQ). Using a large archival sample of pretrial defendants (N = 820), current results suggest that defendants struggled with Miranda abilities regardless of other, individual characteristics. However, verbal intelligence emerged as a very strong predictor of Miranda comprehension such that those with lower VIQ were considerably more vulnerable to impaired comprehension. More so, data suggest that several compounded vulnerabilities (i.e., minoritized racial/ethnic identity status, limited academic achievement, illiteracy) are essential to understanding the extent of vulnerability in the criminal legal …
Date:
December 2023
Creator:
Tazi, Kamar Y.
System:
The UNT Digital Library
The Effects of Implementing a Reward-Based Version of Ostrom's Eight Design Principles as an Intervention Package on Responses in a Common Pool Resource (CPR) Game
The aim of behavior analysis has always been to apply technologies rooted in basic behavioral principles to problems of societal importance (e.g., Skinner, 1948; 1953; 1987). One such problem is the Tragedy of the Commons - a phenomenon arising from systemic failures among a community, leading to the total collapse of a critical resource (Hardin, 1968). Elinor Ostrom's Eight Design Principles were developed to provide a framework for the self-management of common pool resources (CPRs; Ostrom, 1990/2015). When applied as an independently manipulated variable, Ostrom's design principles have shown strong effects in the management of CPRs within the context of a tabletop board game Catan® (Smith & Becker, 2023). This preparation included both rewards (i.e., positive reinforcement) and sanctions (i.e., positive punishment) as a feature of the independent variable. However, it has been well documented that punishing and coercive contingencies can lead to problematic outcomes for individuals and societies (e.g., Sidman, 2001; Skinner, 1976). This study evaluated the effects of utilizing only rewarding consequences in lieu of sanctions in an effort to produce the previously observed control over self-management of a CPR, utilizing the previously adapted rules of the Catan® board game.
Date:
December 2023
Creator:
Paterson, Ian Scott
System:
The UNT Digital Library
The Effects of Specific and Disguised Mands on Staff's Reinforcer Delivery
Residential facilities for adults with developmental disabilities offer essential accommodations and support services, with fostering communication for residents as an important aspect of care. Despite the importance of communication, previous research has identified concerns about staff performance (SP) in facilitating positive social interactions, such as engaging in consequent-mediating behavior for residents' mands. Previous research has primarily focused on improving SP through skills-based training. Yet, Skinner's theory of verbal behavior emphasizes the social and reciprocal nature of mands. Skinner suggests that the listener's behavior, engaging in consequence-mediating behavior, must be conditioned by the verbal community. However, empirical investigations into the reinforcing practices of staff in residential facilities, such as the shaping and sustaining of different types of resident mands, is limited. The current investigation sought to address this gap in research by evaluating if distinct mand topographies, disguised or specific mands, influenced the likelihood of staff engaging in consequence-mediated behavior across three staff-resident dyads. Results suggest a low probability of staff responding to, or reinforcing, mands, thus limiting conclusions on the effects of mand topographies on staff performance. Future directions and considerations regarding resident-staff interactions are discussed.
Date:
December 2023
Creator:
Richey, Caroline Nicole
System:
The UNT Digital Library
The Emergence of Arab Nation-State Nationalism as an Alternative to the Supranational Concept of Ummah
In this dissertation, I examine the political shift or reorientation of Arabs and Muslims from the supranational Ummah to the Western form of nation-state by attending to modern Arabic novel in the period between World War I and World War II. I explore the emergence of secularism in Arab national formation. One of my central arguments is that Arab nationalism is indeed a misleading phrase as it gives the impression of unity and coherence to a complex phenomenon that materialize in a number of trends as a form of struggle. In the first chapter, I defined the scope of my argument and the underlying structure and function of nationalism as a form of representation masked by nationalist ideologies. To investigate the reorientation of Arabs and Muslims from Ummah to adopting nation-state, I utilize Spivak's criticism of the system of representation along with Foucault's theorization of discourse. I argued along Edward Said that although the Western national discourse might have influenced the Arab nationalists, I do not believe they prevented them from consciously appropriating nationalism in a free creative way. I also explained that the Arab adoption of a secularist separatist nationalism was more an outcome than an effect in the …
Date:
December 2023
Creator:
Alhamili, Mohammed Ali M.
System:
The UNT Digital Library
An Empirical Investigation of the Medical Supply Chain and Its Impact on Human Solid Organ Transplantation
The objective of this dissertation is to first identify if there are any academic research gaps in our understanding of the medical supply chain and secondly to understand the role and impact of logistics on the human organ transplant process. The first essay identifies the current status of medical supply chain literature and provides future direction for improving the medical supply chain. This was accomplished by preforming a systematic literature review and a bibliometric analysis from 2,160 publications was conducted. The second essay explores how logistical aspects impact transplant logistics performance and the quality of life for the transplant recipient. Survey data was collected from medical professionals and analyzed using structural equation modeling. The third essay identifies the factors are influencing the number of donor kidneys discarded each year. A retrospective analysis of all deceased donor kidneys procured in hospitals in UNOS region 4 (Texas and Oklahoma) from January 1, 2001, to June 28, 2021, was conducted. Data was analyzed using multinomial logit regression and panel data analysis. As a result, we identified several medical and logistics factors that have influenced the number of donor kidneys discarded in the United States.
Date:
December 2023
Creator:
Hiatt, Brian Joseph
System:
The UNT Digital Library
Environmental Control of Pacing in Cougars
Pacing, a common form of stereotypy in captive animals, poses challenges for animal welfare and conservation initiatives. The current study used a comprehensive measurement system to investigate the impact of introducing a food-related activity on the daily patterns of multiple behaviors, including stereotypic pacing, in two zoo-housed cougars. The results showed that, while the intervention did not mitigate pacing overall, it did cause a shift in the cougars' routines. This demonstrated the significant influence of keeper behavior on the animals. Furthermore, the differing effects on each cougar's behaviors underscored the necessity for individualized interventions tailored to the specific needs of animals.
Date:
December 2023
Creator:
Fahlmann, Elisabeth Anne
System:
The UNT Digital Library
An Evaluation of Cross-Function Stimuli in the Treatment of Automatically Maintained Problem Behavior
Noncontingent reinforcement (NCR) is a possible alternative to differential reinforcement of other behaviors (DRO) that may operate through a similar mechanism. In the research, the participant's problem behaviors were maintained by automatic reinforcement or even multiply maintained. NCR is the method to intervene with the participant who had no clinical effect on using sensory integration therapy (SIT) to reduce problem behaviors in the previous study. The results showed that NCR is an effective way to decrease the problem behaviors without extinction burst.
Date:
December 2023
Creator:
Huang, Po-Kai
System:
The UNT Digital Library
An Evaluation of the Utility of Fixed Ratio 1 Schedule Contingent Reinforcement on Variability to Increase the Diversity of Activity Selections and the Treatment of Problem Behavior Occasioned by Interruption Routines
Adults with autism spectrum disorder (ASD) and intellectual disability (ID) are the majority of population in residential settings. Many clients in residential settings engage in problem behavior that interferes with their daily routine and work requirements. Restricted and repetitive behavior are one of the features of ASD diagnosis, typically in the form of invariable responding and predictable responses. Differential reinforcement has been used to produce and maintain response variability. I evaluated the utility of a fixed ratio 1 (FR1) schedule on variability to increase the diversity of activity selections in the treatment of problem behavior occasioned by the interruption of routines. Chase engaged in problem behaviors in his bathroom routine, no matter by himself or with his housemate. Results demonstrated a reinforcement-based treatment increased both variable and novel selections while decreasing the rate of self injurious behavior.
Date:
December 2023
Creator:
Lin, Yu Chen
System:
The UNT Digital Library
Examination of Potentially Morally Injurious Events and Moral Injury in Medical Professionals
The current study examined the nature and extent of endorsement of PMIEs, the nature and severity of MI symptoms related to endorsement of a PMIE, and the relations between extent of endorsement of PMIEs and MI symptoms. We hypothesized that (1) PMIEs perpetrated by others would be endorsed to a greater extent than PMIEs perpetrated by oneself; (2) medical professionals who endorsed a PMIE would report significantly greater severity on all MI symptoms compared to medical professionals who did not endorse a PMIE; (3) experiencing PMIEs (perpetrated by oneself and/or others) to a greater extent would predict higher levels of MI symptom severity, and MI symptom severity would specifically be most strongly predicted by PMIEs perpetrated by oneself. Hypotheses were examined using t-tests, Pearson's r correlations, and multiple multivariate regression analyses. First, the current study found that PMIEs perpetrated by others were endorsed to a greater extent than those perpetrated by themselves; second, greater exposure to PMIEs was associated with significantly greater severity of 10 of the 14 outcomes. Third, PMIEs perpetrated by oneself predicted more MI symptomatology than PMIEs perpetrated by others, indicating that while PMIEs perpetrated by others are more common, PMIEs perpetrated by oneself are more strongly …
Date:
December 2023
Creator:
Keegan, Fallon
System:
The UNT Digital Library
Examining the Educational Depth of Medical Case Reports and Radiology with Text Mining
The purpose of this dissertation was to use the technology of text mining and topic modeling to explore unobserved themes of medical case reports that involve medical imaging. Case reports have a valuable place in medical research because they provide educational benefits, offer evidence, and encourage discussions. Their form has evolved throughout the years, but they have remained a key staple in providing important information to the medical communities around the world with educational context and illuminating visuals. Examining medical case reports that have been published throughout the years on multiple medical subjects can be challenging, therefore text mining and topic modeling methods were used to analyze a large set of abstracts from medical case reports involving radiology. The total number of abstracts used for the data analysis was 68,845 that were published between the years 1975 to 2022. The findings indicate that text mining and topic modeling can offer a unique and reproducible approach to examine a large quantity of abstracts for theme analysis.
Date:
December 2023
Creator:
Collinsworth, Amy L.
System:
The UNT Digital Library
Experimental and Numerical Investigation of a Novel Cold-Formed Steel Long Span Truss
This thesis describes the experimental and numerical investigation of a novel cold-formed steel 48ft and 54ft long span truss. The truss we designed was to be used as the roofs of large buildings, such as warehouses, hangars, sports arenas. The investigation includes both experimental and numerical testing, the experimental testing of the truss under uniform loads (increasing loads) to determine its deflection and load carrying capacity. The numerical test included developing a finite element model of the truss in SolidWorks and using a finite element model of the truss in ABAQUS to simulate the experimental tests. The findings of this study can be used to improve the design of cold-formed steel long span trusses. The study also provides valuable information for future studies on the modeling of trusses with different cold-formed steel members and the behavior of trusses under load.
Date:
December 2023
Creator:
Nalla, Sai Kumar
System:
The UNT Digital Library
Exploring Psychological Intimate Partner Violence Using Brief Expressive Writing Essays
Non-physical intimate partner violence (NPIPV) is the most pervasive type of abuse, yet literature has predominantly focused on physical IPV victimization. This study employed a mixed-methods design utilizing archival expressive writing data previously collected to identify the presence of NPIPV victimization. Participants wrote about their experience after a relationship dissolution using the expressive writing paradigm. They were asked to share their deepest thoughts and feelings across two sessions. A constructivist grounded theory approach established the theoretical framework for coding the presence of NPIPV acts between romantic partners. Four themes of NPIPV were established (degradation, isolation, control, and jealousy). Disclosure of NPIPV and other themes were also evident in these data. Quantitative analyses assessed changes in participants' psychological distress after completing a brief writing intervention. The intervention increased the likelihood of NPIPV victimization being mentioned from Time 1 to Time 2 writing sessions. This study increases clinical awareness regarding NPIPV by providing insights into this longest-sustained IPV subtype. All participants reported a reduction in avoidance symptoms after completing the writing intervention. Finally, gender continues to complicate this field as researchers must acknowledge both the existence of men's victimization experiences and the greater severity of women's victimization. Clinical implications demonstrate a strength …
Date:
December 2023
Creator:
Laajala, Allison
System:
The UNT Digital Library
Exploring the Association of Language Brokering and Parent-Child Relationship in Korean Immigrant Families
This study focuses on investigating the dynamics of language brokering as Korean immigrant families experience environmental challenges associated with immigration. This study was conducted with qualitative research design with purposive sampling of Korean immigrant families. Six parent-child dyads were recruited and participating children were between 12 to 16 years old. Semi-structured interviews were conducted separately with parents and children in either English or Korean. Thematic analysis was employed for analyzing the transcribed interviews. The Dedoose software program was applied to assist the coding process. 12 subthemes were revealed under four main themes, which were aligned to the study's research questions. The twelve subthemes included parents' dependence on children, vulnerability and resilience of Korean immigrant families, children's socioemotional development through language brokering, and the role of first-born daughter in the family. Parent and child responses indicated how language brokering affects can be a risk in relation to children's development (i.e., with responsibility of language brokering leading the child to experience stress or experience the responsibility of translation as a burden. Positively, respondents indicated that the parent and child experienced a greater sense of empathy for each other's roles. The results derived from this study were aligned with the results of previous …
Date:
December 2023
Creator:
Lee, Eunkyung
System:
The UNT Digital Library
Exploring the Relationship between Mental Health and Substance Use, Stable Housing, and Completion of the RISE Court Program
This thesis analyzes participants of the RISE Court program, a specialized court in Tarrant County, Texas, focusing on women involved in prostitution. The study investigates the intricate relationship between mental health, stable housing, substance abuse, and successful completion of the court program. Through a comprehensive analysis of participant data, the findings reveal insights into the intersection of mental health and the outcomes of participants in the RISE Court program. Contrary to the initial hypotheses, this study presents compelling evidence that mental health issues do not significantly hinder participants from completing the court program nor acquiring stable housing during their participation. However, the data strongly supports the hypothesis that participants with mental health problems are more likely to engage in substance use during the program. Notably, the study found that a substantial portion (71%) of the sample had documented mental health diagnoses, highlighting the pervasive nature of mental health challenges within this demographic. This research represents a considerable stride towards comprehending the complexities surrounding the criminal justice system's interventions for individuals engaged in prostitution, shedding light on the role of mental health in shaping their experiences within the RISE Court program. The findings have implications for the development of more effective, …
Date:
December 2023
Creator:
Smith, Paisley Elizabeth
System:
The UNT Digital Library
Exploring the ROI of 1:1 Computing Programs at the High School Level
This dissertation explored the cost and value of 1:1 computing programs in high schools in Texas. The study examines whether the total cost of ownership of these programs can be justified by the student testing gains and graduation rates. It investigates whether student learning outcomes show a definable correlation between positive gains and the implementation of 1:1 computing programs. The study also explores whether there is a measurable return on investment of 1:1 programs based on testing gains and graduation rates. The research used the State of Texas Assessment of Academic Readiness exam scores to validate assumptions and test the hypothesis. The study found no clear link between the addition of 1:1 computing programs and the realms of student success. While there is marginal improvement in student outcomes, there is only circumstantial evidence that laptops and devices are the catalysts for the change. The dissertation also found that the total cost of ownership (TCO) is a significant portion of the district's spending, costing millions of dollars, and that the financial disclosure and budget information data was either missing, incomplete, or over-generalized, causing an issue for assessing program effectiveness or ROI. Despite this lack of transparency, there is a slight positive …
Date:
December 2023
Creator:
Kissel, Tara Michelle
System:
The UNT Digital Library
Factors Affecting MeHg Contamination of Spiders and Insect-Mediated MeHg Flux from Human-Made Ponds
The present study focused on methylmercury (MeHg) in emergent aquatic insects and spiders from human-made ponds. This dissertation addresses two main topics: (1) factors affecting variation in spider MeHg concentrations around human-made ponds and (2) the magnitude of MeHg transported out of human-made ponds by emergent aquatic insects (insect-mediated MeHg flux). Spiders were specifically targeted in this study because they have been proposed as sentinels of MeHg contamination (organism whose tissue concentrations reflect the level of MeHg in the environment). Spider MeHg concentrations were related to spider diet, size, and proximity to waterbody, but affected individual spider taxa differently. In a second study, I found that only "large" spiders within a taxa had tissue concentrations positively related to prey MeHg concentrations. These results indicate that the relationship between spider and prey MeHg could be size-dependent and that "large" spiders within a taxa may better reflect ambient MeHg contamination. Finally, I tested a conceptual model hypothesizing insect-mediated MeHg flux from human-made ponds is controlled by pond permanence and fish presence. In agreement with the conceptual model, insect-mediated MeHg flux from ponds was suppressed by the presence of fish, likely due to fish predation on emergent insect larvae. I found the mean …
Date:
December 2023
Creator:
Hannappel, Madeline Pratt
System:
The UNT Digital Library
Fatty Acid Amide Hydrolases in Upland Cotton (Gossypium hirsutum L.) and the Legume Model Medicago truncatula
Fatty acid amide hydrolase (FAAH) is a widely conserved amidase in eukaryotes, best known for inactivating the signal of N-acylethanolamine (NAE) lipid mediators. In the plant Arabidopsis thaliana, FAAH-mediated hydrolysis of NAEs has been associated with numerous biological processes. Recently, the phylogenetic distribution of FAAH into two major branches (group I and II FAAHs) across angiosperms outside of Arabidopsis (and in other Brassicaceae), suggests a previously unrecognized complexity of this enzyme. Although A. thaliana has long been used to assess biological questions for plants, in this case it will fall short in understanding the significance of multiple FAAHs in other plant systems. Thus, in this study, I examined the role (s) of six FAAH isoforms in upland cotton (Gossypium hirsutum L.) and two FAAHs in the legume Medicago truncatula.
Date:
December 2023
Creator:
Arias Gaguancela, Omar Paul
System:
The UNT Digital Library
FruitPAL: An IoT-Enabled Framework for Automatic Monitoring of Fruit Consumption in Smart Healthcare
This research proposes FruitPAL and FruitPAL 2.0. They are full automatic devices that can detect fruit consumption to reduce the risk of disease. Allergies to fruits can seriously impair the immune system. A novel device (FruitPAL) detecting fruit that can cause allergies is proposed in this thesis. The device can detect fifteen types of fruit and alert the caregiver when an allergic reaction may have happened. The YOLOv8 model is employed to enhance accuracy and response time in detecting dangers. The notification will be transmitted to the mobile device through the cloud, as it is a commonly utilized medium. The proposed device can detect the fruit with an overall precision of 86%. FruitPAL 2.0 is envisioned as a device that encourages people to consume fruit. Fruits contain a variety of essential nutrients that contribute to the general health of the human body. FruitPAL 2.0 is capable of analyzing the consumed fruit and then determining its nutritional value. FruitPAL 2.0 has been trained on YOLOv5 V6.0. FruitPAL 2.0 has an overall precision of 90% in detecting the fruit. The purpose of this study is to encourage fruit consumption unless it causes illness. Even though fruit plays an important role in people's …
Date:
December 2023
Creator:
Alkinani, Abdulrahman Ibrahim M.
System:
The UNT Digital Library
Glucose-Induced Developmental Delay is Modulated by Insulin Signaling and Exacerbated in Subsequent Glucose-Fed Generations in Caenorhabditis elegans
In this study, we have used genetic, cell biological and transcriptomic methods in the nematode C. elegans as a model to examine the impact of glucose supplementation during development. We show that a glucose-supplemented diet slows the rate of developmental progression (termed "glucose-induced developmental delay" or GIDD) and induces the mitochondrial unfolded protein response (UPRmt) in wild-type animals. Mutation in the insulin receptor daf-2 confers resistance to GIDD and UPRmt in a daf-16-dependent manner. We hypothesized that daf-2(e1370) animals alter their metabolism to manage excess glucose. To test this, we used RNA-sequencing which revealed that the transcriptomic profiles of glucose-supplemented wildtype and daf-2(e1370) animals are distinct. From this, we identified a set of 27 genes which are both exclusively upregulated in daf-2(e1370) animals fed a glucose-supplemented diet and regulated by daf-16, including a fatty acid desaturase (fat-5), and two insulin-like peptides (ins-16 and ins-35). Mutation of any of these genes suppresses the resistance of daf-2(e1370) to GIDD. Additionally, double mutation of ins-16 and ins-35 in a daf-2(e1370) background results in an increase in constitutive dauer formation which is suppressed by glucose supplementation. Further investigation of the insulin-like peptides revealed that ins-16 mutation in a wild-type background results in upregulation of …
Date:
December 2023
Creator:
Nahar, Saifun
System:
The UNT Digital Library