Bruce Merrifield, trained as a biochemist, had to address three major challenges related to the development and acceptance of solid-phase peptide synthesis (SPPS). The challenges were (1) to reduce the concept of peptide synthesis on a insoluble support to practice, (2) overcome the resistance of synthetic chemists to this novel approach, and (3) establish that a biochemist had the scientific credentials to effect the proposed revolutionary change in chemical synthesis. How these challenges were met is discussed in this article.

In the 1949 Report of the Atomic Weights Commission, a series of new elements were added to the Atomic Weights Table. Since these elements had been produced in the laboratory and were not discovered in nature, the atomic weight value of these artificial products would depend upon the production method. Since atomic weight is a property of an element as it occurs in nature, it would be incorrect to assign an atomic weight value to that element. As a result of that discussion, the Commission decided to provide only the mass number of the most stable (or longest-lived) known isotope as the number to be associated with these entries in the Atomic Weights Table. As a function of time, the mass number associated with various elements has changed as longer-lived isotopes of a particular element has been found in nature, or as improved half-life values of an element's isotopes might cause a shift in the longest-lived isotope from one mass to another. In the 1957 Report of the Atomic Weights Commission, it was decided to discontinue the listing of the mass number in the Atomic Weights Table on the grounds that the kind of information supplied by the mass number …

We present a measurement of the branching fraction and photon energy spectrum for the decay B {yields} X{sub s}{gamma} using data from the BABAR experiment. The data sample corresponds to an integrated luminosity of 210 fb{sup -1}, from which approximately 680,000 B{bar B} events are tagged by a fully reconstructed hadronic decay of one of the B mesons. In the decay of the second B meson, an isolated high-energy photon is identified. We measure {Beta}(B {yields} X{sub s}{gamma}) = (3.66 {+-} 0.85{sub stat} {+-} 0.60{sub syst}) x 10{sup -4} for photon energies E{sub {gamma}} above 1.9 GeV in the B rest frame. From the measured spectrum we calculate the first and second moments for different minimum photon energies, which are used to extract the heavy-quark parameters m{sub b} and {mu}{sub {pi}}{sup 2}. In addition, measurements of the direct CP asymmetry and isospin asymmetry are presented.

The elemental (non-volatile) composition of five Stardust impact tracks and terminal particles left from capture of Comet 81P/Wild 2 dust were mapped in a synchrotron x-ray scanning microprobe with full fluorescence spectra at each pixel. Because aerogel includes background levels of several elements of interest, we employ a novel 'dual threshold' approach to discriminate against background contaminants: an upper threshold, above which a spectrum contains cometary material plus aerogel and a lower threshold below which it contains only aerogel. The difference between normalized cometary-plus-background and background-only spectra is attributable to cometary material. The few spectra in between are discarded since misallocation is detrimental: cometary material incorrectly placed in the background spectrum is later subtracted from the cometary spectrum, doubling the loss of reportable cometary material. This approach improves precision of composition quantification. We present the refined whole impact track and terminal particle elemental abundances for the five impact tracks. One track shows mass increases in Cr and Mn (1.4x), Cu, As and K (2x), Zn (4x) and total mass (13%) by dual thresholds compared to a single threshold. Major elements Fe and Ni are not significantly affected. The additional Cr arises from cometary material containing little Fe. We exclude Au …

The High Current Experiment (HCX) is used to study beam transport and accumulation of electrons in quadrupole magnets and the Neutralized Drift-Compression Experiment (NDCX) to study beam transport through and accumulation of electrons in magnetic solenoids. We find that both clearing and suppressor electrodes perform as intended, enabling electron cloud densities to be minimized. Then, the measured beam envelopes in both quadrupoles and solenoids agree with simulations, indicating that theoretical beam current transport limits are reliable, in the absence of electrons. At the other extreme, reversing electrode biases with the solenoid transport effectively traps electrons; or, in quadrupole magnets, grounding the suppressor electrode allows electron emission from the end wall to flood the beam, in both cases producing significant degradation in the beam.

The paper describes the generalization of the method to produce secondary particles with a low-energy and low-intensity primary beam circulating in a Storage Ring with the Emittance-Recovery by Internal-Target (ERIT).

We present a summary on ongoing simulation results for the electron-cloud buildup in the context of the proposed FNAL Main Injector (MI) intensity upgrade [1] in a fieldfree region at the location of the RFA electron detector [2]. By combining our simulated results for the electron flux at the vacuum chamber wall with the corresponding measurements obtained with the RFA we infer that the peak secondary electron yield (SEY) {delta}{sub max} is {approx}> 1.4, and the average electron density is n{sub e} {approx}> 10{sup 10} m{sup -3} at transition energy for the specific fill pattern and beam intensities defined below. The sensitivity of our results to several variables remains to be explored in order to reach more definitive results. Effects from the electron cloud on the beam are being investigated separately [3].

Flow and dispersion processes in urban areas are profoundly influenced by the presence of buildings which divert mean flow, affect surface heating and cooling, and alter the structure of turbulence in the lower atmosphere. Accurate prediction of velocity, temperature, and turbulent kinetic energy fields are necessary for determining the transport and dispersion of scalars. Correct predictions of scalar concentrations are vital in densely populated urban areas where they are used to aid in emergency response planning for accidental or intentional releases of hazardous substances. Traditionally, urban flow simulations have been performed by computational fluid dynamics (CFD) codes which can accommodate the geometric complexity inherent to urban landscapes. In these types of models the grid is aligned with the solid boundaries, and the boundary conditions are applied to the computational nodes coincident with the surface. If the CFD code uses a structured curvilinear mesh, then time-consuming manual manipulation is needed to ensure that the mesh conforms to the solid boundaries while minimizing skewness. If the CFD code uses an unstructured grid, then the solver cannot be optimized for the underlying data structure which takes an irregular form. Unstructured solvers are therefore often slower and more memory intensive than their structured counterparts. …

Various gain models have shown the potentially great advantages of Fast Ignition (FI) Inertial Confinement Fusion (ICF) over its conventional hot spot ignition counterpart [e.g., S. Atzeni, Phys. Plasmas 6, 3316 (1999); M. Tabak et al., Fusion Sci. & Technology 49, 254 (2006)]. These gain models, however, all assume nearly uniform-density fuel assemblies. In contrast, conventional ICF implosions yield hollowed fuel assemblies with a high-density shell of fuel surrounding a low-density, high-pressure hot spot. Hence, to realize fully the advantages of FI, an alternative implosion design must be found which yields nearly isochoric fuel assemblies without substantial hot spots. Here, it is shown that a self-similar spherical implosion of the type originally studied by Guderley [Luftfahrtforschung 19, 302 (1942)] may be employed to yield precisely such quasi-isochoric imploded states. The difficulty remains, however, of accessing these self-similarly imploding configurations from initial conditions representing an actual ICF target, namely a uniform, solid-density shell at rest. Furthermore, these specialized implosions must be realized for practicable drive parameters and at the scales and energies of interest in ICF. A direct-drive implosion scheme is presented which meets all of these requirements and reaches a nearly isochoric assembled density of 300 g=cm{sup 3} and areal …

Heating by irradiation of a solid surface in vacuum with 5 x 10{sup 20} W cm{sup -2}, 0.8 ps, 1.05 {micro}m wavelength laser light is studied by x-ray spectroscopy of the K-shell emission from thin layers of Ni, Mo and V. A surface layer is heated to {approx} 5 keV with an axial temperature gradient of 0.6 {micro}m scale length. Images of Ni Ly{sub {alpha}} show the hot region has a {approx} 25 {micro}m diameter, much smaller than {approx} 70 {micro}m region of K{sub {alpha}} emission. 2D particle-in-cell (PIC) simulations suggest that the surface heating is due to a light pressure driven shock.

Synthetic Cd{sub 1-x}Zn{sub x}Te or 'CZT' crystals are highly suitable for the room temperature-based spectroscopy of gamma radiation. Structural/morphological heterogeneities within CZT, such as secondary phases that are thought to consist of Te metal and have detrimental impacts on detector performance. In this study, we used electron and X-ray-based imaging techniques to examine heterogeneous properties of detector grade CZT. Using experimental analytical techniques rather than arbitrary theoretical definitions, our study identifies two dominant secondary phase morphologies. The first consists of numerous empty, 20 {micro} m wide, pyramidal bodies (tetrahedra) or 'negative' crystals with trace quantities of particulate residue that exist as 65 nm sized particles containing Si, Cd, Zn, and Te. The other consists of 20 {micro}m hexagonal-shaped bodies, which are composites of metallic Te layers that contain a teardrop-shaped core of amorphous and polycrystalline CdZnTe which finally surrounds an irregular-shaped void.

Using electron energy-loss spectroscopy in a transmission electron microscope, many-electron atomic spectral calculations and density functional theory, we examine the electronic and magnetic structure of Cm metal. We show that angular momentum coupling in the 5f states plays a decisive role in the formation of the magnetic moment. The 5f states of Cm in intermediate coupling are strongly shifted towards the LS coupling limit due to exchange interaction, unlike most actinide elements where the effective spin-orbit interaction prevails. It is this LS-inclined intermediate coupling that is the key to producing the large spin polarization which in turn dictates the newly found crystal structure of Cm under pressure.

A bench-scale feasibility study on the use of a Wet Air Oxidation (WAO) process to destroy a slurry laden with tetraphenylborate (TPB) compounds has been undertaken. WAO is an aqueous phase process in which soluble and/or insoluble waste constituents are oxidized using oxygen or oxygen in air at elevated temperatures and pressures ranging from 150 C and 1 MPa to 320 C and 22 MPa. The products of the reaction are CO{sub 2}, H{sub 2}O, and low molecular weight oxygenated organics (e.g. acetate, oxalate). Test results indicate WAO is a feasible process for destroying TPB, its primary daughter products [triphenylborane (3PB), diphenylborinic acid (2PB), and phenylboronic acid (1PB)], phenol, and most of the biphenyl byproduct. The required conditions are a temperature of 300 C, a reaction time of 3 hours, 1:1 feed slurry dilution with 2M NaOH solution, the addition of CuSO{sub 4}.5H{sub 2}O solution (500 mg/L Cu) as catalyst, and the addition of 2000 mL/L of antifoam. However, for the destruction of TPB, its daughter compounds (3PB, 2PB, and 1PB), and phenol without consideration for biphenyl destruction, less severe conditions (280 C and 1-hour reaction time with similar remaining above conditions) are adequate.

Canary rockfish (Sebastes pinniger) have long been an important part of recreational and commercial rockfish fishing from southeast Alaska to southern California, but localized stock abundances have declined considerably. Based on age estimates from otoliths and other structures, lifespan estimates vary from about 20 years to over 80 years. For the purpose of monitoring stocks, age composition is routinely estimated by counting growth zones in otoliths; however, age estimation procedures and lifespan estimates remain largely unvalidated. Typical age validation techniques have limited application for canary rockfish because they are deep dwelling and may be long lived. In this study, the unaged otolith of the pair from fish aged at the Department of Fisheries and Oceans Canada was used in one of two age validation techniques: (1) lead-radium dating and (2) bomb radiocarbon ({sup 14}C) dating. Age estimate accuracy and the validity of age estimation procedures were validated based on the results from each technique. Lead-radium dating proved successful in determining a minimum estimate of lifespan was 53 years and provided support for age estimation procedures up to about 50-60 years. These findings were further supported by {Delta}{sup 14}C data, which indicated a minimum estimate of lifespan was 44 {+-} 3 …

Simulations of atmospheric flow through urban areas must account for a wide range of physical phenomena including both mesoscale and urban processes. Numerical weather prediction models, such as the Weather and Research Forecasting model (WRF), excel at predicting synoptic and mesoscale phenomena. With grid spacings of less than 1 km (as is required for complex heterogeneous urban areas), however, the limits of WRF's terrain capabilities and subfilter scale (SFS) turbulence parameterizations are exposed. Observations of turbulence in urban areas frequently illustrate a local imbalance of turbulent kinetic energy (TKE), which cannot be captured by current turbulence models. Furthermore, WRF's terrain-following coordinate system is inappropriate for high-resolution simulations that include buildings. To address these issues, we are implementing significant modifications to the ARW core of the Weather Research and Forecasting model. First, we are implementing an improved turbulence model, the Dynamic Reconstruction Model (DRM), following Chow et al. (2005). Second, we are modifying WRF's terrain-following coordinate system by implementing an immersed boundary method (IBM) approach to account for the effects of urban geometries and complex terrain. Companion papers detailing the improvements enabled by the DRM and the IBM approaches are also presented (by Mirocha et al., paper 13.1, and K.A. Lundquist …

This presentation will highlight the U.S. Department of Energy’s (DOE) FutureGen project − a $1 billion government-industry partnership to design, build, and operate a near-zero emissions coal-fueled power plant. The lead organization for the FutureGen initiative is the National Energy Technology Laboratory (NETL), a multi-purpose laboratory operated by the U.S. DOE’s Office of Fossil Energy. NETL has a mission to conduct R&D from fundamental science to technology demonstration for resolving the environmental, supply, and reliability constraints of producing and using fossil energy resources. The commercial-scale FutureGen R&D facility is a pathway toward future fossil-energy power plants that will produce hydrogen and electricity while nearly eliminating emissions, including carbon dioxide. The 275-megawatt FutureGen plant will initiate operations around 2012 and employ advanced coal gasification technology integrated with combined cycle electricity generation, hydrogen production, and carbon capture and sequestration. Low carbon emissions would be achieved by integrating CO2 capture and sequestration operations with the power plant.

All experiments at the National Ignition Facility (NIF) will produce debris and shrapnel from vaporized, melted, or fragmented target/diagnostics components. For some experiments mitigation is needed to reduce the impact of debris and shrapnel on optics and diagnostics. The final optics, e.g., wedge focus lens, are protected by two layers of debris shields. There are 192 relatively thin (1-3 mm) disposable debris shields (DDS's) located in front of an equal number of thicker (10 mm) main debris shields (MDS's). The rate of deposition of debris on DDS's affects their replacement rate and hence has an impact on operations. Shrapnel (molten and solid) can have an impact on both types of debris shields. There is a benefit to better understanding these impacts and appropriate mitigation. Our experiments on the Omega laser showed that shrapnel from Ta pinhole foils could be redirected by tilting the foils. Other mitigation steps include changing location or material of the component identified as the shrapnel source. Decisions on the best method to reduce the impact of debris and shrapnel are based on results from a number of advanced simulation codes. These codes are validated by a series of dedicated experiments. One of the 3D codes, NIF's …

The slowing pace of commodity microprocessor performance improvements combined with ever-increasing chip power demands has become of utmost concern to computational scientists. As a result, the high performance computing community is examining alternative architectures that address the limitations of modern cache-based designs. In this work, we examine the potential of using the recently-released STI Cell processor as a building block for future high-end computing systems. Our work contains several novel contributions. First, we introduce a performance model for Cell and apply it to several key scientific computing kernels: dense matrix multiply, sparse matrix vector multiply, stencil computations, and 1D/2D FFTs. The difficulty of programming Cell, which requires assembly level intrinsics for the best performance, makes this model useful as an initial step in algorithm design and evaluation. Next, we validate the accuracy of our model by comparing results against published hardware results, as well as our own implementations on a 3.2GHz Cell blade. Additionally, we compare Cell performance to benchmarks run on leading superscalar (AMD Opteron), VLIW (Intel Itanium2), and vector (Cray X1E) architectures. Our work also explores several different mappings of the kernels and demonstrates a simple and effective programming model for Cell's unique architecture. Finally, we propose modest …

This research describes a non-invasive, non-contact method used to quantitatively analyze the functional characteristics of tissue. Multi-spectral images collected at several near-infrared wavelengths are input into a mathematical optical skin model that considers the contributions from different analytes in the epidermis and dermis skin layers. Through a reconstruction algorithm, we can quantify the percent of blood in a given area of tissue and the fraction of that blood that is oxygenated. Imaging normal tissue confirms previously reported values for the percent of blood in tissue and the percent of blood that is oxygenated in tissue and surrounding vasculature, for the normal state and when ischemia is induced. This methodology has been applied to assess vascular Kaposi's sarcoma lesions and the surrounding tissue before and during experimental therapies. The multi-spectral imaging technique has been combined with laser Doppler imaging to gain additional information. Results indicate that these techniques are able to provide quantitative and functional information about tissue changes during experimental drug therapy and investigate progression of disease before changes are visibly apparent, suggesting a potential for them to be used as complementary imaging techniques to clinical assessment.

The photoionization and photoelectron spectroscopy of pure He droplets are investigated at photon energies between 24.6 eV (the ionization energy of He) and 28 eV. Time-of-flight mass spectra and photoelectron images were obtained at a series of molecular beam source temperatures and pressures to assess the effect of droplet size on the photoionization dynamics. At source temperatures below 16 K, the photoelectron images are dominated by fast electrons produced via direct ionization of He atoms, with a small contribution from very slow electrons with kinetic energies below 1 meV arising from an indirect mechanism. The fast photoelectrons have as much as 0.5 eV more kinetic energy than those from atomic He at the same photon energy. This result is interpreted and simulated within the context of a 'dimer model', in which one assumes vertical ionization from two nearest neighbor He atoms to the attractive region of the He2+ potential energy curve. Possible mechanism for the slow electrons, which were also seen at energies below IE(He), are discussed, including vibrational autoionizaton of Rydberg states comprising an electron weakly bound to the surface of a large HeN+ core.

We report recent measurements for the branching fractions of charmless hadronic B decays obtained from data collected by the BABAR detector at the PEP-II asymmetric-energy collider at the Stanford Linear Accelerator Center.

The authors report the results of a study of the decays B{sup +} {yields} J/{psi}{omega}K{sup +} and B{sup 0} {yields} J/{psi}{omega}K{sub S}{sup 0} using 383 million B{bar B} events from {Upsilon}(4S) decays with the BABAR detector at the PEP-II asymmetric-energy e{sup +}e{sup -} storage rings. They observe evidence for Y(3940) {yields} J/{psi}{omega} with product branching fractions {Beta}(B{sup +} {yields} Y K{sup +}, Y {yields} J/{psi}{omega}) = (4.9 {+-} 1.0(stat) {+-} 0.5(syst)) x 10{sup -5} and {Beta}(B{sup 0} {yields} Y K{sup 0}, Y {yields} J/{psi}{omega}) = (1.5{sub -1.2}{sup +1.4}(stat){sub -0.2}{sup +0.2}(syst)) x 10{sup -5}. The measured mass and width are M(Y) = (3914.6{sub -3.4}{sup +3.8}(stat){sub -1.9}{sup +1.9}(syst)) MeV/c{sup 2} and {Lambda}(Y) = (33{sub -8}{sup +12}(stat){sub -5}{sup +5}(syst)) MeV, respectively.

The B-model topological string theory on a Calabi-Yau threefold X has a symmetry group {Lambda}, generated by monodromies of the periods of X. This acts on the topological string wave function in a natural way, governed by the quantum mechanics of the phase space H{sup 3}(X). We show that, depending on the choice of polarization, the genus g topological string amplitude is either a holomorphic quasi-modular form or an almost holomorphic modular form of weight 0 under {Lambda}. Moreover, at each genus, certain combinations of genus g amplitudes are both modular and holomorphic. We illustrate this for the local Calabi-Yau manifolds giving rise to Seiberg-Witten gauge theories in four dimensions and local IP{sub 2} and IP{sub 1} x IP{sub 1}. As a byproduct, we also obtain a simple way of relating the topological string amplitudes near different points in the moduli space, which we use to give predictions for Gromov-Witten invariants of the orbifold C{sub 3}/ZZ{sub 3}.

Experiments with 1.5-g Shock-Dispersed-Fuel (SDF) charges have been conducted in six different chambers. Both flake Aluminum and TNT were used as the fuel. Static pressure gauges on the chamber wall were the main diagnostic. Waveforms for explosions in air were significantly larger than those in nitrogen - thereby demonstrating a strong thermobaric (combustion) effect. This effect increases as the confinement volume decreases and the mixture richness approaches 1.