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17β-Estradiol Delivered in Eye Drops: Evidence of Impact on Protein Networks and Associated Biological Processes in the Rat Retina through Quantitative Proteomics (open access)

17β-Estradiol Delivered in Eye Drops: Evidence of Impact on Protein Networks and Associated Biological Processes in the Rat Retina through Quantitative Proteomics

Study analyzes target engagements through the identification of functional protein networks impacted after delivery of 17β-estradiol in eye drops to facilitate the development of broad-spectrum retina neuroprotectants that can be delivered through topical dosage forms.
Date: January 27, 2020
Creator: Prókai, László, 1958-; Zaman, Khadiza; Nguyen, Vien & Prokai-Tatrai, Katalin
Object Type: Article
System: The UNT Digital Library
Adherence to Exercise Programs in Older Adults: Informative Report (open access)

Adherence to Exercise Programs in Older Adults: Informative Report

This article focuses on filling information gaps regarding adherence to physical activity and exercise in the health care spectrum of older adults (OA) and an overview of the benefits of physical activity for OA. Exercise adherence in OA is a multifactorial problem encompassing many biopsychosocial factors. Factors affecting adherence in the OA include socioeconomic status, education level, living arrangements, health status, pacemakers, physical fitness, and depression. Improving adherence could have a significant impact on longevity, quality of life, and health care costs.
Date: January 22, 2019
Creator: Rivera-Torres, Solymar; Fahey, Thomas D. & Rivera, Miguel A.
Object Type: Article
System: The UNT Digital Library
Aircraft-Assisted Pilot Suicides in the General Aviation Increased for One-Year Period after 11 September 2001 Attack in the United States (open access)

Aircraft-Assisted Pilot Suicides in the General Aviation Increased for One-Year Period after 11 September 2001 Attack in the United States

The article describes a study that evaluated the possible effect the 11 September 2001, terrorist attacks had on pilot AASs in the U.S. Fatal aviation accidents in the National Transportation Safety Board (NTSB) database were searched using the following search words: “suicide”, “murder-suicide” and “homicide-suicide”. The timeline between 11 September 1996, and 11 September 2004, was analyzed. This study showed an association, albeit not determinate causal effect, of a very specific series of simultaneous terrorist murder-suicides with subsequent pilot AASs.
Date: November 12, 2018
Creator: Vuorio, Alpo; Laukkala, Tanja; Junttila, Ilkka; Bor, Robert; Budowle, Bruce; Pukkala, Eero et al.
Object Type: Article
System: The UNT Digital Library
Alcohol Withdrawal and Brain Injuries: Beyond Classical Mechanisms (open access)

Alcohol Withdrawal and Brain Injuries: Beyond Classical Mechanisms

This review attempts to provide integrated information at the levels of oxidative signaling mechanisms by which ethanol withdrawal (EW) provokes brain injuries and 17β-estradiol (E2) protects against it. Unmanaged sudden withdrawal from the excessive consumption of alcohol (ethanol) adversely alters neuronal integrity in vulnerable brain regions such as the cerebellum, hippocampus, or cortex.
Date: July 20, 2010
Creator: Jung, Marianna E. & Metzger, Daniel B.
Object Type: Article
System: The UNT Digital Library
Association of Home Food Availability with Prediabetes and Diabetes among Adults in the United States (open access)

Association of Home Food Availability with Prediabetes and Diabetes among Adults in the United States

This article examined associations of home food availabilities with prediabetes and diabetes among 8929 adults (20–70 years) participating in 2007–2010 National Health and Nutrition Examination Surveys. The results show prediabetes participants had lower availability of healthy foods and higher availability of unhealthy foods, suggesting the need to improve healthy food availability at home for this population.
Date: April 25, 2020
Creator: McAtee, Jenniffer; Tao, Meng-Hua; King, Christian & Chai, Weiwen
Object Type: Article
System: The UNT Digital Library
Barriers for pregnant women living in rural, agricultural villages to accessing antenatal care in Cambodia: A community-based cross-sectional study combined with a geographic information system (open access)

Barriers for pregnant women living in rural, agricultural villages to accessing antenatal care in Cambodia: A community-based cross-sectional study combined with a geographic information system

Article describes how morbidity and mortality is still a major public health issue in low- and middle-income countries such as Cambodia. This study examines the barriers for pregnant women living in rural, agricultural villages.
Date: March 19, 2018
Creator: Yasuoka, Junko; Nanishi, Keiko; Kikuchi, Kimiyo; Suzuki, Sumihiro; Ly, Po; Thavrin, Boukheng et al.
Object Type: Article
System: The UNT Digital Library
Biodiversity of protists and nematodes in the wild nonhuman primate gut (open access)

Biodiversity of protists and nematodes in the wild nonhuman primate gut

Article describes study which used an 18S rRNA gene fragment metabarcoding approach to assess the eukaryotic assemblage of 62 individuals representing 16 nonhuman primate NHP species to better understand the factors that influence the assembly and diversity of gut-associated eukaryotes.
Date: November 12, 2019
Creator: Mann, Allison E.; Mazel, Florent; Lemay, Matthew A.; Morien, Evan; Billy, Vincent; Kowalewski, Martin et al.
Object Type: Article
System: The UNT Digital Library
Brain Delivery of Thyrotropin-Releasing Hormone via a Novel Prodrug Approach (open access)

Brain Delivery of Thyrotropin-Releasing Hormone via a Novel Prodrug Approach

Using thyrotropin-releasing hormone (TRH) as a model, paper explores whether synergistic combination of lipoamino acid(s) and a linker cleaved by prolyl oligopeptidase (POP) can be used as a promoiety for prodrug design for the preferential brain delivery of the peptide.
Date: July 18, 2019
Creator: Prokai-Tatrai, Katalin; De La Cruz, Daniel L.; Nguyen, Vien; Ross, Benjamin P.; Toth, Istvan & Prókai, László, 1958-
Object Type: Article
System: The UNT Digital Library
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-2 (open access)

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-2

This article is part of a series of Editorials published biannually that highlights a number of recently published articles that describe crucial findings.
Date: December 28, 2017
Creator: Muñoz-Torrero, Diego; Mangoni, Arduino A; Liu, Hong; Hulme, Christopher; Rautio, Jarkko; Karaman, Rafik et al.
Object Type: Article
System: The UNT Digital Library
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-3 (open access)

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-3

A series of editorials highlighting in brief reports recently published articles describing crucial findings in the field of medical chemistry.
Date: June 30, 2018
Creator: Mangoni, Arduino A; Tuccinardi, Tiziano; Collina, Simona; Vanden Eynde, Jean Jacques; Muñoz-Torrero, Diego; Karaman, Rafik et al.
Object Type: Article
System: The UNT Digital Library
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-4 (open access)

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-4

The article is part of a series of Editorials published biannually that highlights a number of recently published articles that describe crucial findings. This article highlights 25 different articles that range from asthma treatment to new oral β-lactamase inhibitor (BLI).
Date: December 31, 2018
Creator: Mangoni, Arduino A; Guillou, Catherine; Vanden Eynde, Jean Jacques; Hulme, Christopher; Jampilek, Josef; Li, Wei et al.
Object Type: Article
System: The UNT Digital Library
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5 (open access)

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5

The article is part of a series of Editorials published biannually that highlights a number of recently published articles that describe crucial findings.
Date: June 30, 2019
Creator: Mangoni, Arduino A; Vanden Eynde, Jean Jacques; Jampilek, Josef; Hadjipavlou-Litina, Dimitra; Liu, Hong; Reynisson, Jóhannes et al.
Object Type: Article
System: The UNT Digital Library
Cataract Preventive Role of Isolated Phytoconstituents: Findings from a Decade of Research (open access)

Cataract Preventive Role of Isolated Phytoconstituents: Findings from a Decade of Research

This review aims to find effective phytoconstituents in cataract treatments in vitro, ex vivo, and in vivo. Scientists have focused their attention not only for anti-cataract activity in vitro, but also in ex vivo and in vivo from the review of active phytoconstituents in medicinal plants. In our present review, we identified 58 active phytoconstituents with strong anti-cataract effects at in vitro and ex vivo with lack of in vivo studies.
Date: October 26, 2018
Creator: Lim, Vuanghao; Schneider, Edward; Wu, Hongli & Pang, Iok-Hou
Object Type: Article
System: The UNT Digital Library
Chemical Conditioning as an Approach to Ischemic Stroke Tolerance: Mitochondria as the Target (open access)

Chemical Conditioning as an Approach to Ischemic Stroke Tolerance: Mitochondria as the Target

This article focuses on chemical conditioning of mitochondrial proteins as targets for neuroprotection against ischemic stroke injury.
Date: March 8, 2016
Creator: Jin, Zhen; Wu, Jinzi & Yan, Liang-Jun
Object Type: Article
System: The UNT Digital Library
Chronic Inhibition of Mitochondrial Dihydrolipoamide Dehydrogenase (DLDH) as an Approach to Managing Diabetic Oxidative Stress (open access)

Chronic Inhibition of Mitochondrial Dihydrolipoamide Dehydrogenase (DLDH) as an Approach to Managing Diabetic Oxidative Stress

This article investigates if chronic inhibition of DLDH could also attenuate oxidative stress in type 2 diabetes. It is the authors' belief that DLDH inhibition could be a novel approach to fighting type 2 diabetes.
Date: February 2, 2019
Creator: Yang, Xiaojuan; Song, Jing & Yan, Liang-Jun
Object Type: Article
System: The UNT Digital Library
Copycats in Pilot Aircraft-Assisted Suicides after the Germanwings Incident (open access)

Copycats in Pilot Aircraft-Assisted Suicides after the Germanwings Incident

Paper describes studying aiming to evaluate changes in pilot aircraft-assisted suicide risks, i.e., a copycat effect, in the U.S. and Germany after the Germanwings 2015 incident in the French Alps.
Date: March 11, 2018
Creator: Laukkala, Tanja; Vuorio, Alpo; Bor, Robert; Budowle, Bruce; Navathe, Pooshan; Pukkala, Eero et al.
Object Type: Article
System: The UNT Digital Library

Data from the National Library of Medicine

Presentation for the 2017 UNT Open Access Symposium. This presentation provides an overview of data types and repositories for accessing data from the National Library of Medicine.
Date: May 19, 2017
Creator: Burgard, Daniel E.
Object Type: Presentation
System: The UNT Digital Library
Development of Biodegradable Nanocarriers Loaded with a Monoclonal Antibody (open access)

Development of Biodegradable Nanocarriers Loaded with a Monoclonal Antibody

This article examines the feasibility of encapsulating monoclonal antibodies within poly(lactic-co-glycolic acid) (PLGA) nanoparticles using a water/oil/water double emulsion solvent evaporation technique. This method can be used to prepare protective polymeric nanoparticles for transporting functional antibodies to the cytoplasmic compartment of cancer cells. The author's studies achieved successful formulation of antibody loaded polymeric nanoparticles, thus indicating that a PLGA-based antibody nanoformulation is a promising intracellular delivery vehicle for a large number of new intracellular antibody targets in cancer cells.
Date: February 12, 2015
Creator: Gdowski, Andrew; Ranjan, Amalendu; Mukerjee, Anindita & Vishwanatha, Jamboor
Object Type: Article
System: The UNT Digital Library
Direct Analysis in Real Time (DART) of an Organothiophosphate at Ultrahigh Resolution by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry and Tandem Mass Spectrometry (open access)

Direct Analysis in Real Time (DART) of an Organothiophosphate at Ultrahigh Resolution by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry and Tandem Mass Spectrometry

Paper describes results of an analysis of the organothiophosphate malathion using DART-Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry (MS) and tandem mass spectrometry (MS/MS).
Date: January 16, 2016
Creator: Prókai, László, 1958- & Stevens, Stanley M.
Object Type: Article
System: The UNT Digital Library
Distinct Roles of mTOR Targets S6K1 and S6K2 in Breast Cancer (open access)

Distinct Roles of mTOR Targets S6K1 and S6K2 in Breast Cancer

The purpose of this article is to compare and contrast the expression, structure, regulation and function of these two S6K homologs in breast cancer.
Date: February 11, 2020
Creator: Sridharan, Savitha & Basu, Alakananda
Object Type: Article
System: The UNT Digital Library
The Emerging Roles of mTORC1 in Macromanaging Autophagy (open access)

The Emerging Roles of mTORC1 in Macromanaging Autophagy

Review critically analyzes current literature to provide an integrated view of how rapamycin complex 1 (mTORC1) regulates various steps of the autophagy process.
Date: September 24, 2019
Creator: Dossou, Akpedje S. & Basu, Alakananda
Object Type: Article
System: The UNT Digital Library
The Enigmatic Protein Kinase C-eta (open access)

The Enigmatic Protein Kinase C-eta

The purpose of this review article is to discuss how PKCη regulates various cellular processes that may contribute to its contrasting roles in cancer. Protein kinase C-eta (PKCη) is a unique member of the PKC family since its regulation is distinct from other PKC isozymes. PKCη was shown to regulate cell proliferation, differentiation and cell death.
Date: February 13, 2019
Creator: Basu, Alakananda
Object Type: Article
System: The UNT Digital Library
Expression and Function of Transient Receptor Potential Ankyrin 1 Ion Channels in the Caudal Nucleus of the Solitary Tract (open access)

Expression and Function of Transient Receptor Potential Ankyrin 1 Ion Channels in the Caudal Nucleus of the Solitary Tract

The article describes a study that tested and confirmed the hypothesis that TRPA1 expressed in the primary sensory afferents may modulate the function of second order NTS neurons. The expression of TRPA1 was detected in presynaptic locations, but not the somata of caudal NTS neurons that did not express TRPA1 mRNA or proteins. Moreover, caudal NTS neurons did not show somatodendritic responsiveness to TRPA1 agonists, while TRPA1 immunostaining was detected only in the afferent fibers.
Date: April 26, 2019
Creator: Feng, Lin; Uteshev, Victor V. & Premkumar, Louis S.
Object Type: Article
System: The UNT Digital Library
Flanking Variation Influences Rates of Stutter in Simple Repeats (open access)

Flanking Variation Influences Rates of Stutter in Simple Repeats

This article shows that rates of stutter can vary substantially depending on the flanking haplotype, and while there are cases where the LUS is a better predictor of stutter than the PAL, examples to the contrary are apparent in commonly assayed forensic markers. Further, flanking variation that is 7 bp from the repeat region can impact rates of stutter. These findings suggest that non-proximal effects, such as DNA secondary structure, may be impacting the rates of stutter in common forensic short tandem repeat markers.
Date: November 17, 2017
Creator: Woerner, August E.; King, Jonathan L. & Budowle, Bruce
Object Type: Article
System: The UNT Digital Library