Report discussing currently available machine learning (ML) medical diagnostic technologies for five selected diseases, emerging ML medical diagnostic technologies, challenges affecting the development and adoption of ML technologies for medical diagnosis, and policy options to help address challenges in the use of artificial intelligence (AI) technologies in health care (Part One). Part Two presents a framework for evaluating and promoting provider adoption of new AI-assisted diagnostic decision support tools (AI-DDS), centered on four integrated domains: 1) Reason to Use, 2) Means to Use, 3) Methods to Use, and 4) Desire to Use.