Accelerometer-Based Automated Counting of Ten Exercises without Exercise-Specific Training or Tuning (open access)

Accelerometer-Based Automated Counting of Ten Exercises without Exercise-Specific Training or Tuning

Article presents research that creates an automatic repetition counting system that is flexible enough to measure multiple distinct and repeating movements during physical therapy without being trained on the specific motion.
Date: October 10, 2020
Creator: Zelman, Samuel; Dow, Michael; Tabashum, Thasina; Xiao, Ting & Albert, Mark
Object Type: Article
System: The UNT Digital Library
An approach for reliably identifying high-frequency oscillations and reducing false-positive detections (open access)

An approach for reliably identifying high-frequency oscillations and reducing false-positive detections

Article states that high-frequency oscillation (HFO), classified as ripples (80-240 Hz) and fast ripples (240-500 Hz), is regarded as a promising biomarker of epilepsy. The authors presented an integrated, multi-layered procedure capable of automatically rejecting HFOs from a variety of common false positives, such as motion, background signals, and sharp transients.
Date: September 2, 2022
Creator: Zhou, Yufeng; You, Jing; Kumar, Udaya; Weiss, Shennan A.; Bragin, Anatol; Engel Jr., Jerome et al.
Object Type: Article
System: The UNT Digital Library
Bioengineering Systems for Modulating Notch Signaling in Cardiovascular Development, Disease, and Regeneration (open access)

Bioengineering Systems for Modulating Notch Signaling in Cardiovascular Development, Disease, and Regeneration

This article is a review summarizing the significant roles of Notch signaling in individual cardiac cell types. It covers the bioengineering systems of microfluidics, hydrogel, spheroid, and 3D bioprinting and provides insights into ancillary supports of bioengineering systems, varied types of cardiovascular cells, and advanced characterization approaches in further refining Notch signaling in cardiovascular development, disease, and regeneration.
Date: September 30, 2021
Creator: Huerta Gomez, Angello; Joshi, Sanika; Yang, Yong; Tune, Johnathan D. & Zhao, Ming-Tao
Object Type: Article
System: The UNT Digital Library
CAREER: A Prosthetic Elbow with Network of Soft and Modular Thermo-Active Actuators for Mobility Impaired Patients (open access)

CAREER: A Prosthetic Elbow with Network of Soft and Modular Thermo-Active Actuators for Mobility Impaired Patients

Data management plan for the grant "CAREER: A Prosthetic Elbow with Network of Soft and Modular Thermo-Active Actuators for Mobility Impaired Patients." This NSF Faculty Early Career Development (CAREER) project will develop novel networks of flexible Peltier-based soft actuators designed for rehabilitation.
Date: 2021-10-01/2026-03-31
Creator: Jafari, Amir
Object Type: Text
System: The UNT Digital Library
CAREER: Shape Memory Polymers as Biomaterial (open access)

CAREER: Shape Memory Polymers as Biomaterial

Data management plan for the grant, "CAREER: Shape Memory Polymers as Biomaterial." This CAREER projectaimsto elucidate the underlying mechanism of the plasticization-induced shape memory effect of thiol-enebased polymers. The model application for this material will be a heat shrink tubing that can shrink at bodily conditions (37° C and simulated body fluids) and can be used to seal colonic anastomosis. The specific three aims are to (1) Systematically investigate the effect of crosslink-density and chain extender length on theplasticization-induced shape memory effect of thiol-enebased polymers. Mechanical and thermomechanical measurements inside simulated body fluids will be used to assess shape memory properties and structure-property relationships. (2) Understand the relationship between material thickness, degree of shape-programming, and radial recovery forces of tube-shaped SMPs to determine optimal design parameters for sufficient shape recovery using the heat shrink tube model. (3) Demonstrate the functionality of a biomedical heat shrink tube that utilizes the plasticization-induced shape recovery through an ex vivo colon anastomosis model and quantify mechanical and sealing properties.
Date: 2023-02-01/2028-01-31
Creator: Ecker, Melanie
Object Type: Text
System: The UNT Digital Library
Child Health and Human Development Extramural Research (open access)

Child Health and Human Development Extramural Research

Data management plan for the grant, "Child Health and Human Development Extramural Research." This study will use the genome-edited human induced pluripotent stem cell (hiPSC) with NOTCH1 knockout to recapitulate the genetic variants of NOTCH1 mutation in the Hypoplastic left heart syndrome (HLHS). It will use advances in the vascularized cardiac organoid directly differentiated from hiPSCs to replay the development and function of cardiomyocytes, endothelial cells, smooth muscle cells, and other cardiac cells in a defined 3D cell culture model by stencil-based micropatterning. It will elucidate the pathogenesis of cardiovascular underdevelopment and dysfunction found in HLHS with NOTCH1 mutation via the NOTCHDELTA/JAG ligand-receptor binding and multicellular crosstalk by single-cell RNA-seq and proteomics analysis.
Date: 2022-09-08/2025-08-31
Creator: Yang, Huaxiao
Object Type: Text
System: The UNT Digital Library
A consensus statement on detection of hippocampal sharp wave ripples and differentiation from other fast oscillations (open access)

A consensus statement on detection of hippocampal sharp wave ripples and differentiation from other fast oscillations

Article suggests that common standards for recording, detection, and reporting for intracranial recordings in humans that suggest their role in episodic and semantic memory does not exist. Authors of the article outline the methodological challenges involved in detecting ripple events and offer practical recommendations to improve separation from other high-frequency oscillations, and argue that shared experimental, detection, and reporting standards will provide a solid foundation for future translational discovery.
Date: October 12, 2022
Creator: Liu, Anli A.; Henin, Simon; Abbaspoor, Saman; Bragin, Anatol; Buffalo, Elizabeth A.; Farrell, Jordan S. et al.
Object Type: Article
System: The UNT Digital Library
Current methods for fabricating 3D cardiac engineered constructs (open access)

Current methods for fabricating 3D cardiac engineered constructs

Article is a review highlighting the various cell types found in cardiac tissues and how they correspond with current advanced fabrication methods for creating cardiac engineered constructs.
Date: May 20, 2022
Creator: Rogozinski, Nicholas; Yanez, Apuleyo; Bhoi, Rahulkumar; Lee, Moo-Yeal & Yang, Huaxiao
Object Type: Article
System: The UNT Digital Library
Deep learning for peptide identification from metaproteomics datasets (open access)

Deep learning for peptide identification from metaproteomics datasets

This article explores a proposed deep-learning-based algorithm called DeepFilter for improving peptide identifications from a collection of tandem mass spectra. The authors find that DeepFilter is believed to generalize properly to new, previously unseen peptide-spectrum-matches and can be readily applied in peptide identification from metaproteomics data.
Date: July 8, 2021
Creator: Feng, Shichao; Sterzenbach, Ryan & Guo, Xuan
Object Type: Article
System: The UNT Digital Library
Detection of Parkinson's Disease Through Automated Pupil Tracking of the Post-illumination Pupillary Response (open access)

Detection of Parkinson's Disease Through Automated Pupil Tracking of the Post-illumination Pupillary Response

This article describes a system for pupil size estimation with a user interface to allow rapid adjustment of parameters and extraction of pupil parameters of interest in order to identify Parkinson's disease (PD) as early as possible.
Date: March 25, 2021
Creator: Tabashum, Thasina; Zaffer, Adnaan; Yousefzai, Raman; Colletta, Kalea; Jost, Mary Beth; Park, Youngsook et al.
Object Type: Article
System: The UNT Digital Library
Detergent-Based Decellularization for Anisotropic Cardiac-Specific Extracellular Matrix Scaffold Generation (open access)

Detergent-Based Decellularization for Anisotropic Cardiac-Specific Extracellular Matrix Scaffold Generation

Article describes how cell-derived extracellular matrix has become increasingly popular in tissue engineering applications due to its ability to provide tailored signals for desirable cellular responses. The objective of this study was to assess the efficacy of two detergent-based decellularization methods: a combination of ethylenediaminetetraacetic acid and sodium dodecyl sulfate and a combination of sodium deoxycholate and deoxyribonuclease.
Date: November 17, 2023
Creator: Chen, Te-An; Sharma, Dhavan; Jia, Wenkai; Ha, Donggi; Man, Kun; Zhang, Jianhua et al.
Object Type: Article
System: The UNT Digital Library
Development of Genetic Sensors and Circuits for Creating Novel Cellular Behaviors (open access)

Development of Genetic Sensors and Circuits for Creating Novel Cellular Behaviors

Data management plan for the grant "Development of Genetic Sensors and Circuits for Creating Novel Cellular Behaviors." This research is expected to advance the capability to engineer organisms for biomedical uses. Specifically, the outcomes of this project include design principles for engineering regulators from different protein families, an extensive set of genetic sensors for detecting a broad range of signals, and novel genetic circuits that address uprising problems in biomedical fields. It uses a novel multidisciplinary approach to enhance the health of the nation by creating tools that facilitate both medical-related discoveries and the implementation of new strategies for biomedical applications.
Date: 2021-09-15/2026-08-31
Creator: Chan, Clement T. Y.
Object Type: Text
System: The UNT Digital Library
Differential Responses of Transplanted Stem Cells to Diseased Environment Unveiled by a Molecular NIR-II Cell Tracker (open access)

Differential Responses of Transplanted Stem Cells to Diseased Environment Unveiled by a Molecular NIR-II Cell Tracker

This article develops a molecular cell tracker with a strong fluorescence signal in the second near-infrared (NIR-II) window (1,000-1,700 nm) for real-time monitoring of in vivo cell behaviors in both healthy and diseased animal models to address the issue of precisely and quantitatively evaluating the in vivo cell distribution, migration, and engraftment in stem cell therapy.
Date: June 9, 2021
Creator: Chen, Hao; Yang, Huaxiao; Zhang, Chen; Chen, Si; Zhao, Xin; Zhu, Mark et al.
Object Type: Article
System: The UNT Digital Library
Flexible and Stretchable Bioelectronics (open access)

Flexible and Stretchable Bioelectronics

Article reviewing several several flexible and stretchable materials used as substrate, stretchable electrical conduits and encapsulation, design modifications for stretchability, fabrication techniques, methods of signal transmission and monitoring, and the power sources for these stretchable bioelectronics. Ultimately, these bioelectronic devices can be used for wide range of applications from skin bioelectronics and biosensing devices, to neural implants for diagnostic or therapeutic purposes.
Date: December 20, 2021
Creator: Chitrakar, Chandani; Hedrick, Eric; Adegoke, Lauren & Ecker, Melanie
Object Type: Article
System: The UNT Digital Library
Harnessing nanofiber alignment and pore size to promote stem cell self-renewal and differentiation (open access)

Harnessing nanofiber alignment and pore size to promote stem cell self-renewal and differentiation

Article describes how stem cell therapy holds immense potential for regenerative medicine, but its applications are limited due to the loss of pluripotency during in vitro expansion. This study reveals that the arrangement of electrospun fibers aligns with the distribution and strength of the electric field through both experimentation and simulation.
Date: July 25, 2023
Creator: Wei, Qiang; Blake, Laurence; Liu, Jiafeng; Man, Kun; Liang, Cindy; Teoh, Alexandra et al.
Object Type: Article
System: The UNT Digital Library
Hedgehog signaling is involved in acquired resistance to KRASG12C inhibitors in lung cancer cells (open access)

Hedgehog signaling is involved in acquired resistance to KRASG12C inhibitors in lung cancer cells

Article states that although KRASG12C inhibitors have shown promising activity in lung adenocarcinomas harboring KRASG12C, acquired resistance to these therapies eventually occurs in most patients. The authors report that the hedgehog signal is induced by KRASG12C inhibitors and mediates KRAS re-expression in cancer cells treated with a KRASG12C inhibitor.
Date: January 16, 2024
Creator: Lee, Chaeyoung; Yi, Jawoon; Park, Jihwan; Ahn, Byungyong; Won, Young-Wook; Jeon, JiHeung et al.
Object Type: Article
System: The UNT Digital Library
Hidden Markov model-based activity recognition for toddlers (open access)

Hidden Markov model-based activity recognition for toddlers

Article describes study which sought to evaluate methods for activity recognition for toddlers.
Date: March 5, 2020
Creator: Albert, Mark; Sugianto, Albert; Nickele, Katherine; Zavos, Patricia; Sindu, Pinky; Ali, Munazza et al.
Object Type: Article
System: The UNT Digital Library
In-vitro biomineralization and biocompatibility of friction stir additively manufactured AZ31B magnesium alloy-hydroxyapatite composites (open access)

In-vitro biomineralization and biocompatibility of friction stir additively manufactured AZ31B magnesium alloy-hydroxyapatite composites

Article presents research where friction stir additive manufacturing technique was employed to fabricate AZ31B magnesium-hydroxyapatite composite. The study aims to evaluate effect of hydroxyapatite (HA, Ca₁₀(PO₄)₆OH₂), a ceramic similar to natural bone, into AZ31B Mg alloy matrix on biomineralization and biocompatibility.
Date: June 30, 2020
Creator: Ho, Yee-Hsien; Man, Kun; Joshi, Sameehan; Pantawane, Mangesh V.; Wu, Tso-Chang; Yang, Yong et al.
Object Type: Article
System: The UNT Digital Library
Light-Controlled Cell–Cell Assembly Using Photocaged Oligonucleotides (open access)

Light-Controlled Cell–Cell Assembly Using Photocaged Oligonucleotides

Article asserts that while techniques that allow one to control the arrangement of cells and direct contact between different cell types have been developed that expand upon simple co-culture methods, specific control over heterojunctions that form between cells is not easily accomplished with current methods, such as 3D cell-printing. In this article, DNA-mediated cell interactions are combined with cell-compatible photolithographic approaches to control cell assembly.
Date: May 23, 2023
Creator: Mathis, Katelyn; Kohon, Agia Ibnat; Black, Stephen & Meckes, Brian
Object Type: Article
System: The UNT Digital Library
Mechanoregulators of Nanoparticle-Cell Interactions at Tissue Interfaces (open access)

Mechanoregulators of Nanoparticle-Cell Interactions at Tissue Interfaces

Data management plan for the grant, "Mechanoregulators of Nanoparticle-Cell Interactions at Tissue Interfaces."
Date: 2023-09-01/2028-07-31
Creator: Meckes, Brian
Object Type: Text
System: The UNT Digital Library
Mesenchymal stem cells aligned and stretched in self-assembling peptide hydrogels (open access)

Mesenchymal stem cells aligned and stretched in self-assembling peptide hydrogels

Article describes how the presented research highlights a novel approach using fmoc-protected peptide hydrogels for the encapsulation and stretching of mesenchymal stem cells. This study utilized a custom mechanical stretching device with a PDMS chamber to stretch human mesenchymal stem cells encapsulated in Fmoc hydrogels.
Date: December 19, 2023
Creator: Fouladgar, Farzaneh; Moslabeh, Forough G. Z.; Kasani, Yashesh V.; Rogozinski, Nick; Torres, Marc; Ecker, Melanie et al.
Object Type: Article
System: The UNT Digital Library
Modulating 3D Cellular Connectivity Via Spatially-Controlled Programmable Bonding (open access)

Modulating 3D Cellular Connectivity Via Spatially-Controlled Programmable Bonding

Data management plan for the grant "Modulating 3D Cellular Connectivity Via Spatially-Controlled Programmable Bonding." This project seeks to demonstrate proof-of-concept for technology that allows one to systematically place cells on substrates to create complex 3D assemblies with precise control over individual cellular interactions. The technology generated within this proposal will open new avenues for studying multicellular communication pathways, stem cell differentiation, and understanding developmental processes. Spatially-defined cell-cell communication plays a critical role in numerous disease and developmental processes that include osteoarthritic degeneration, cancer metastasis, and organ regeneration.
Date: 2021-09-01/2023-08-31
Creator: Meckes, Brian
Object Type: Text
System: The UNT Digital Library
Multifaceted Shape Memory Polymer Technology for Biomedical Application: Combining Self-Softening and Stretchability Properties (open access)

Multifaceted Shape Memory Polymer Technology for Biomedical Application: Combining Self-Softening and Stretchability Properties

Article describes how thiol-ene polymers are a promising class of biomaterials with a wide range of potential applications, including organs-on-a-chip, microfluidics, drug delivery, and wound healing. This study investigated the incorporation of di-acrylate chain extenders to improve the stretchability and conformability of those flexible thiol-ene polymers.
Date: October 25, 2023
Creator: Chitrakar, Chandani; Torres, Marc Anthony; Rocha-Flores, Pedro Emanuel; Hu, Qichan & Ecker, Melanie
Object Type: Article
System: The UNT Digital Library
Nanocrown electrodes for parallel and robust intracellular recording of cardiomyocytes (open access)

Nanocrown electrodes for parallel and robust intracellular recording of cardiomyocytes

Article develops vertically-aligned nanocrown electrodes that are mechanically robust and achieve > 99% success rates in obtaining intracellular access through electroporation. This technology development provides an advancement towards establishing an iAP screening assay for preclinical evaluation of drug-induced arrhythmogenicity.
Date: April 26, 2022
Creator: Jahed, Zeinab; Yang, Yang; Tsai, Ching-Ting; Foster, Ethan P.; McGuire, Allister F.; Yang, Huaxiao et al.
Object Type: Article
System: The UNT Digital Library