Regional population growth and increasing trade with Mexico are creating severe traffic congestion along Interstate 35 and at the Laredo bridge crossings. The construction of a new Interstate Highway 69 has been offered as one solution to this problem. This analysis examines the economic impacts of building Interstate 69 and its potential impact on job creation in the counties along its projected path. Using the IMPLAN input-output modeling system, construction of Interstate 69 will support $4.2 billion in economic activity in the counties through which it will pass. More importantly, based on an analysis of Interstate 27 in west Texas, it can be projected that Interstate 69 will spur a 2% gain in regional employment above any usual economic growth.