Three individuals were inadvertently exposed to polonium. Activity determinations on the routine weekly urine samples submitted by the individuals revealed counts of 174, 734, and 2190 c/min/50 ml respectively. An investigation was immediately launched to determine the source of the exposure, since there was no report of a spill or accident involving active material. By the process of elimination, the time of exposure was narrowed down to a time when two of the individuals were engaged in the denitration of a polonium solution in a small kettie inside a hood when a leak developed in the kettle. The active solution was transferred from the kettle to a carboy. All three individuals were present during the transfer period. Two wore respirators, rubber gloves, and smocks over their coveralls while the third stood well behind and watched the procedure. However, it was concluded that an inhalation exposure resulted. A medical study of each case was instituted and data are summarized. No immediate toxic effects were observed. (C.H.)

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It was agreed during a meeting on July 10, 1945 that an investigation should be made by the Technical Department to determine how fast and in what fashion the temperature of the effluent water from the 100 Areas is dissipated in the columbia River. A preliminary report on this investigation is submitted herewith for review by interested parties.

A test dose of Zr{sup 95} was given to a female patient which had a metastatic reticula endothelial tumor at the distal portion of the left femur. A comparison of the deposition of Zr{sup 95} showed greater uptake 24 hours after administration than any of the normal tissues investigated.

X-ray diffraction patterns have been obtained from a sample of elemental polonium over a period of more than four half-lives. This time study was made for the purpose of determining the effect of decay upon the lattice constants and crystal structure of the element.

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An investigation of the assimilation, distribution, retention, an excretion of the fission products and actinide elements in the rat has been conducted at the Crocker Radiation Laboratory, University of California, Berkeley, California. These studies were initiated October 15, 1942, and are continuing at the present time. An extensive survey has been made of the metabolism of twenty-two different radio elements in the rat.

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This monthly progress report covers the following programs: (1) 184-inch Cyclotron; (2) 60-inch Cyclotron; (3) Synchrotron; (4) Linear Accelerator; (5) Experimental Physics; (6) Theoretical Physics; (7) Chemistry; (8) Medical Physics; and (9) Health Physics and Chemistry.

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The identity and relative yields of about twenty of the radioisotopes produced by the bombardment of natural copper with 190 Mev deuterons and 380 Mev helium ions have been determined. Two previously unreported isotopes were detected: Zn{sup 62}, decaying by orbital electron capture with a 9.5-hour half-life, and Fe{sup 52}, decaying by positron emission with a 7.8-hour half-life.

Methods for the recovery of C/sup 14/ from neutron-irradiated Re/sub 3/N/ sub 2/, based on solution in acid and alkali. are outlined. (C.J.G.)

Both acid and alkaline dissolutions of Be/sub 3/N/sub 2/ were carried The recommended alkaline dissolution procedure is outlined. (M.H.R.)

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