The purpose of this study was to examine the association between engaging in minimum levels of physical activity as defined by ACSM and perceived quality of life. A total of 43 college students were included in a repeated measures, quasi-experimental design research study that produced an overall retention rate of 65%, which resulted in 15 students being placed in the treatment group, and 28 students being placed in the control group. Analysis of variance with repeated measures was used to compare the quality of life mean scores over three administrations of the Quality of Life Inventory (QOLI), which resulted in no significant main effects for either the time measure or the group measure, but did produce a significant interaction effect. Post hoc analyses showed there was a significant difference between the treatment and control groups' quality of life mean scores only during the second administration of the instrument. Further analysis showed that the control group had significantly higher quality of life domain scores for six of the 16 quality of life domains. There were no significant differences between groups across any of the physiological measures. These findings did not support previous research that increasing individuals' level of physical activity will …