The Yucca Mountain site was recommended by the President to be a geological repository for commercial spent nuclear fuel and high-level radioactive waste. The multi-barrier approach was adopted for assessing and predicting system behavior, including both natural barriers and engineered barriers. A major component of the long-term strategy for safe disposal of nuclear waste is first to completely isolate the radionuclides in waste packages for long times and then to greatly retard the egress and transport of radionuclides from penetrated packages. The goal of the Materials Performance Targeted Thrust program is to further enhance the understanding of the role of engineered barriers in waste isolation. In addition, the Thrust will explore technical enhancements and seek to offer improvements in materials costs and reliability.