The transforming growth factor-betas (TGF{beta}s) are members of a large superfamily of pleiotropic cytokines that also includes the activins and the bone morphogenetic proteins (BMPs). Members of the TGF{beta} family regulate complex physiological processes such cell proliferation, differentiation, adhesion, cell-cell and cell-matrix interactions, motility, and cell death, among others (Massague, 1998). Dysregulation of TGF{beta} signaling contributes to several pathological processes including cancer, fibrosis, and auto-immune disorders (Massague et al., 2000). The TGF{beta}s elicit their biological effects by binding to type II and type I transmembrane receptor serine-threonine kinases (T{beta}RII and T{beta}RI) which, in turn, phosphorylated Smad 2 and Smad 3. Phosphorylated Smad 2/3 associate with Smad 4 and, as a heteromeric complex, translocate to the nucleus where they regulate gene transcription. The inhibitory Smad7 down regulates TGF{beta} signaling by binding to activated T{beta}RI and interfering with its ability to phosphorylate Smad 2/3 (Derynck and Zhang, 2003; Shi and Massague, 2003). Signaling is also regulated by Smad proteolysis. TGF{beta} receptor-mediated activation results in multi-ubiquitination of Smad 2 in the nucleus and subsequent degradation of Smad 2 by the proteasome (Lo and Massague, 1999). Activation of TGF{beta} receptors also induces mobilization of a Smad 7-Smurf complex from the nucleus to the cytoplasm; …

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The National Museum of the Pacific War presents an oral interview with John Ladd. Mr Ladd was sworn into the Navy July 12, 1938. After boot camp, he was assigned to the USS Maryland (BB-46) which was stationed in Long Beach and San Pedro, California at the time. The Maryland moved to Pearl Harbor in the late summer of 1941. Ladd was a gunner's mate on one of the 5-inch broadside guns. On December 7, 1941, the guns were secured and the ammunition was locked up. It took them about ten minutes to get to where they could start shooting back at the Japanese planes. Ladd tells the story of shooting down two or three American planes early in the morning of December 8th that were trying to land. He also talks about getting men out of the ships that had been sunk in the harbor including the Oklahoma that had capsized next to them. Just before Christmas 1941, the Maryland was patched up enough to sail for Bremerton, Washington for repairs. Afterwards, she went back to Pearl Harbor. Ladd was transferred off in late October 1943 and went to gunnery school in Washington, DC for three months. After school, …

The National Museum of the Pacific War presents an oral interview with John Ladd. Mr Ladd was sworn into the Navy July 12, 1938. After boot camp, he was assigned to the USS Maryland (BB-46) which was stationed in Long Beach and San Pedro, California at the time. The Maryland moved to Pearl Harbor in the late summer of 1941. Ladd was a gunner's mate on one of the 5-inch broadside guns. On December 7, 1941, the guns were secured and the ammunition was locked up. It took them about ten minutes to get to where they could start shooting back at the Japanese planes. Ladd tells the story of shooting down two or three American planes early in the morning of December 8th that were trying to land. He also talks about getting men out of the ships that had been sunk in the harbor including the Oklahoma that had capsized next to them. Just before Christmas 1941, the Maryland was patched up enough to sail for Bremerton, Washington for repairs. Afterwards, she went back to Pearl Harbor. Ladd was transferred off in late October 1943 and went to gunnery school in Washington, DC for three months. After school, …

The dominant landscape process on the Arctic Coastal Plain of northern Alaska is the formation and drainage of thaw lakes. Lakes and drained thaw lake basins account for approximately 75% of the modern surface expression of the Barrow Peninsula. The thaw lake cycle usually obliterates lacustrine or peat sediments from previous cycles which could otherwise be used for paleoecological reconstruction of long-term landscape and vegetation changes. Several possible erosional remnants of a former topographic surface that predates the formation of the thaw lakes have been tentatively identified. These remnants are characterized by a higher elevation, a thick organic layer with very high ground ice content in the upper permafrost, and a plant community somewhat atypical of the region. Ten soil cores were collected from one site, and one core was intensively sampled for soil organic carbon content, pollen analysis, and {sup 14}C dating. The lowest level of the organic sediments represents the earliest phase of plant growth and dates to ca. 9000 cal BP. Palynological evidence indicates the presence of mesic shrub tundra (including sedge, birch, willow, and heath vegetation); and microfossil indicators point to wetter eutrophic conditions during this period. Carbon accumulation was rapid due to high net primary …

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