Authors of the article assert that isoflavonoids play important roles in plant defense and also exhibit a range of mammalian health-promoting activities. They emphasize that understanding the structural basis of isoflavone biosynthesis will facilitate the engineering of new bioactive isoflavonoids.

This article proposes that the integration of these signals is mediated through pulses of gene expression that are coordinated through out the plant in a systemic manner by the ROS/Ca⁺² waves.

Article says that horizontal gene transfer (HGT) is a major source of phenotypic innovation and a mechanism of niche adaptation in prokaryotes. Methods for detecting HGT can be classified into phylogenetic-based and parametric or composition-based approaches, so authors exploited the complementary strengths of both the approaches to construct a high confidence horizontal gene flow network. The scale-free horizontal gene flow network presented here provides new insights into modes of transfer for the exchange of genetic information and also illuminates differential gene flow across phyla.

This article reviews the book "River Notes: A Natural and Human History of the Colorado" by Wade Davis.

This article tests if it is possible to piggyback more than one antisense deoxyoligonucleotide (dO) with one vivo morpholino (VMO). The authors previously developed a piggyback knockdown method that was used to knockdown genes in adult zebrafish. In this article, the authors develop a method to knockdown three genes at one time, and by increasing the concentration of VMO by twofold, could knockdown six genes simultaneously. These multiple gene knockdowns will not only increase the efficiency of the method in whole genome-wide knockdowns but will also be useful to study multifactorial disorders.

This article identifies that an rRNA released in hemolysis activates clotting in human and zebrafish plasma. Furthermore, it shows that fish Hgfac plays a role in rRNA-mediated activation of coagulation.

Article on secreted frizzled related proteins and implications in cancers.

Article describes how, in his 1945 Nobel Prize acceptance speech, Sir Alexander Fleming warned of antimicrobial resistance (AMR) if the necessary precautions were not taken diligently. This paper explores the applications of ML in predicting and understanding AMR, highlighting its potential in revolutionizing healthcare practices.

Article on simvastatin sensitizes human gastric cancer xenograft in nude mice to capecitabine by suppressing nuclear factor-kappa B-regulated gene products.

Article on targeted down-regulation of cytochrome P450 enzymes for forage quality improvement in alfalfa (Medicago sativa L.).

Article reviews PPARγ as an antitumor agent and summarizes the antineoplastic effects of PPARγ agonists in prostate cancer.

Article on terpene biosynthesis in glandular trichomes of hop.

Article discusses how the global sequencing of microRNA (miRNA; miR) and integration to downstream mRNA expression profiles in early life stages (ELS) of fish following exposure to crude oil determined consistently dysregulated miRNAs regardless of the oil source or fish species. The overlay of differentially expressed miRNAs and mRNAs into in silico software determined that the key roles of these miRNAs were predicted to be involved in cardiovascular, neurological and visually-mediated pathways.

Article on the use of genetics for the management of a recovering population and a temporal assessment of migratory peregrine falcons in North America.

Article describes how, since the discovery of the second chromosome in the Rhodobacter spaeroides 2.4.1 in 1989 and the revelation of gene sequences, multipartite genomes have been reported in over three hundred bacterial species under nine different phyla. In this study, the authors have attempted to leverage machine learning as a means to identify the genetic factors that underlie the differentiation of bacteria with multipartite and unipartite genomes.

Book chapter on vanillin biosynthesis. The author gives an introduction to vanillin biosynthesis, the multiple pathways to vanillin, and the way forward.

Article discussing how WD40 repeat protein from Medicago truncatula is necessary for tissue-specific anthocyanin and proanthocyanidin biosynthesis but not for trichome development.

This commentary extends a discussion initiated by Toussaint et al. (Sci Rep 6:22125, 2016) concerning the relationship between global patterns of freshwater fish functional diversity (FD) and its vulnerability to human impacts.

Article testing the hypothesis that domesticated camelids occurred in prehispanic, southern Mendoza through analysis of ancient DNA.

This column article discusses the impact of Robert Boutillier and Graham Shelton's 1986 Journal of Experimental Biology paper "Gas exchange, storage and transport in voluntarily diving Xenopus laevis."

Article discussing the eXtensible Genome Data Broker (xGDB) and an open-source computational infrastructure for the integrated evaluation and anlysis of genome features.

Video recording of Dr. Pudur Jagadeeswaran's presentation, "Zebrafish Genetics: Functional Genomics." It focuses on blood coagulation pathways in studying functional genomics. It was presented at the Transdisciplinary Ancestral Genomic Research Investigations (TAGRI) II Conference held online November 5-6, 2021.