This study compared auditory behavioral and physiologic measures in normal control subjects and subjects prescribed with a selective serotonin reuptake inhibitor (SSRI) who were yet to take the drug and those currently taking an SSRI. Test measures used were pure tone averages (PTA), acoustic reflex thresholds, uncomfortable loudness levels (UCL), otoacoustic emissions, masking level difference, temporal integration, amplitude resolution, and Beck Depression Inventory-II (BDI-II) scores. Results indicated that there was a significant difference in the amplitude resolution of the unmedicated group when compared to the medicated and the control group. There was also a significant positive correlation between dynamic range (difference between UCL and PTA) and amplitude resolution. The BDI-II revealed a significant difference between the scores of the unmedicated and the control group as well as the medicated and the control group. Although other test measures indicated differences between the groups, the differences were not statistically significant.