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Lipid Droplets: Packing Hydrophobic Molecules Within the Aqueous Cytoplasm
Article discusses how lipid droplets, also known as oil bodies or lipid bodies, are plant organelles that compartmentalize neutral lipids as a hydrophobic matrix covered by proteins embedded in a phospholipid monolayer. The authors review the growing body of knowledge about lipid droplets in plant cells, describe the evolutionary similarity and divergence in their associated subcellular machinery, and point to gaps that deserve future attention.
Date:
November 22, 2022
Creator:
Guzha, Athanas; Whitehead, Payton; Ischebeck, Till & Chapman, Kent Dean
Object Type:
Article
System:
The UNT Digital Library
The protein conformational basis of isoflavone biosynthesis
Authors of the article assert that isoflavonoids play important roles in plant defense and also exhibit a range of mammalian health-promoting activities. They emphasize that understanding the structural basis of isoflavone biosynthesis will facilitate the engineering of new bioactive isoflavonoids.
Date:
November 15, 2022
Creator:
Wang, Xiaoqiang; Pan, Haiyun; Sagurthi, Someswar; Paris, Vincent; Zhuo, Chunliu & Dixon, R. A.
Object Type:
Article
System:
The UNT Digital Library
Transgenic manipulation of triacylglycerol biosynthetic enzymes in B. napus alters lipid-associated gene expression and lipid metabolism
Article asserts that oilseed rape (Brassica napus) is an important crop that is cultivated for the oil (mainly triacylglycerol; TAG) it produces in its seeds. The author's results show that up-regulation of these key enzymes differentially affects lipid composition and distribution as well as lipid-associated gene expression, providing important information which could be used to improve crop properties by metabolic engineering.
Date:
March 1, 2022
Creator:
Liao, Pan; Lechon, Tamara; Romsdahl, Trevor; Woodfield, Helen K.; Fenyk, Stepan; Fawcett, Tony et al.
Object Type:
Article
System:
The UNT Digital Library
Prebiotic/probiotic supplementation resulted in reduced visceral fat and mRNA expression associated with adipose tissue inflammation, systemic inflammation, and chronic disease risk
Article describes how prebiotic/probiotic supplementation represents a viable option for addressing elevated systemic inflammation and chronic disease risk in overweight individuals. The key findings support that 90-day prebiotic/probiotic supplementation may be associated with reduced adipose tissue inflammation, reduced systemic inflammation, and reduced chronic disease risk.
Date:
November 28, 2022
Creator:
McFarlin, Brian K.; Tanner, Elizabeth A.; Hill, David W. & Vingren, Jakob L.
Object Type:
Article
System:
The UNT Digital Library
Fatty acid amide hydrolase and 9-lipoxygenase modulate cotton seedling growth by ethanolamide oxylipin levels
Article asserts that polyunsaturated N-acylethanolamines (NAEs) can be hydrolyzed by fatty acid amide hydrolase (FAAH) or oxidized by lipoxygenase (LOX). Altogether, the authors conclude that the growth of cotton seedlings involves fine-tuning of 9-NAE-HOD levels via FAAH-mediated hydrolysis and LOX-mediated production, expanding the mechanistic understanding of plant growth modulation by NAE oxylipins to a perennial crop species.
Date:
December 6, 2022
Creator:
Gaguancela-Arias, Omar; Aziz, Mina & Chapman, Kent Dean
Object Type:
Article
System:
The UNT Digital Library
Are Tourists Facilitators of the Movement of Free-Ranging Dogs?
Article discusses how free-ranging dogs are of major conservation concern worldwide as they negatively affect wildlife. Although scientists and governmental agencies are aware of the problem and responsible pet ownership strategies are beginning to be implemented, the tourism sector must be explicitly integrated into wildlife conservation management strategies.
Date:
December 16, 2022
Creator:
Schüttler, Elke & Jiménez, Jaime E.
Object Type:
Article
System:
The UNT Digital Library
The complexities of proanthocyanidin biosynthesis and its regulation in plants
Article describes how proanthocyanidins (PAs) are natural flavan-3-ol polymers that contribute protection to plants under biotic and abiotic stress, benefits to human health, and bitterness and astringency to food products. This review extends the conventional understanding with recent findings that provide new insights to address lingering questions and focus strategies for manipulating PA traits in plants.
Date:
November 26, 2022
Creator:
Yu, Keji; Song, Yushuang; Lin, Jinxing & Dixon, R. A.
Object Type:
Article
System:
The UNT Digital Library
A polar insect's tale: Observations on the life cycle of Parochlus steinenii, the only winged midge native to Antarctica
Article asserts that Antarctica and the sub-Antarctic islands include some of the world’s most extreme and pristine terrestrial habitats. The authors studied the habitat preferences and the life history of P. steinenii in Lake Kitiesh, Fildes Peninsula, King George Island over the austral summer seasons from 2014 to 2019, during short (several weeks) field expeditions.
Date:
December 24, 2022
Creator:
Mejias, Tamara Contador; Gañán, Melisa; Rendoll Cárcamo, Javier; Maturana, Claudia S.; Benítez, Hugo A.; Kennedy, James H. et al.
Object Type:
Article
System:
The UNT Digital Library
Transcriptomic profiling of miR-203a inhibitor and miR-34b-injected zebrafish (Danio rerio) validates oil-induced neurological, cardiovascular and eye toxicity response pathways
Article discusses how the global sequencing of microRNA (miRNA; miR) and integration to downstream mRNA expression profiles in early life stages (ELS) of fish following exposure to crude oil determined consistently dysregulated miRNAs regardless of the oil source or fish species. The overlay of differentially expressed miRNAs and mRNAs into in silico software determined that the key roles of these miRNAs were predicted to be involved in cardiovascular, neurological and visually-mediated pathways.
Date:
November 21, 2022
Creator:
Maguson, Jason T.; Leads, Rachel R.; McGruer, Victoria; Qian, Le; Tanabe, Philip; Roberts, Aaron P. et al.
Object Type:
Article
System:
The UNT Digital Library
Molecular signatures in the progression of COVID-19 severity
Authors of the article discuss that to uncover genes and pathways involved in the differential clinical manifestations of COVID-19 they developed a novel gene co-expression network-based pipeline that uses gene expression obtained from different SARS-CoV-2 infected human tissues. Their study shines a new light on genes and their networks (modules) that drive the progression of COVID-19 from moderate to extremely severe condition, which could aid development of new therapeutics to combat COVID-19.
Date:
December 21, 2022
Creator:
De, Ronika & Azad, Rajeev K.
Object Type:
Article
System:
The UNT Digital Library
The Subantarctic Rayadito (Aphrastura subantarctica), a new bird species on the southernmost islands of the Americas
Article describes a new taxon of terrestrial bird of the genus Aphrastura (rayaditos) inhabiting the Diego Ramírez Archipelago, the southernmost point of the American continent. The authors state that the discovery of this endemic passerine highlights the need to monitor and conserve this still-pristine archipelago devoid of exotic species, which is now protected by the recently created Diego Ramírez Islands-Drake Passage Marine Park.
Date:
August 26, 2022
Creator:
Rozzi, Ricardo, 1960-; Quilodrán, Claudio S.; Botero-Delgadillo, Esteban; Napolitano, Constanza; Torres-Mura, Juan C.; Barroso, Omar et al.
Object Type:
Article
System:
The UNT Digital Library
Retraction Note: Gold Nanoparticles‑enabled Efficient Dual Delivery of Anticancer Therapeutics to HeLa cells
The editors have retracted their article Gold Nanoparticles-enabled Efficient Dual Delivery of Anticancer Therapeutics to HeLa cells. Concerns were brought to the attention of the Editors with respect to apparent inappropriate manipulation of the data in seven of the nine panels shown in Figure 7. The Editors no longer have confidence in the data reported in this Article.
Date:
July 5, 2022
Creator:
Farooq, Muhammad U.; Novosad, Valentyn; Rozhkova, Elena A.; Wali, Hussain; Ali, Asghar; Fateh, Ahmed A. et al.
Object Type:
Article
System:
The UNT Digital Library
A role for ascorbate conjugates of (+)-catechin in proanthocyanidin polymerization
Article describes how both biochemically and genetically, that ascorbate (AsA) is an alternative “starter unit” to flavan-3-ol monomers for leucocyanidin-derived (+)-catechin subunit extension in the Arabidopsis thaliana anthocyanidin synthase (ans) mutant. The authors' findings advance the knowledge of (+)-catechin-type PA extension and indicate that PA oligomerization does not necessarily proceed by sequential addition of a single extension unit. AsA-[C]n defines a new type of PA intermediate which we term “sub-PAs”.
Date:
June 14, 2022
Creator:
Yu, Keji; Dixon, R. A. & Duan, Changquing
Object Type:
Article
System:
The UNT Digital Library
Inhaled diesel exhaust particles result in microbiome‑related systemic inflammation and altered cardiovascular disease biomarkers in C57Bl/6 male mice
Article discusses the authors' investigation the hypothesis that exposure to inhaled diesel exhaust particles alters the gut microbiome and promotes microbial-related inflammation and cardiovascular disease biomarkers. To determine whether probiotics could prevent diet or DEP exposure mediated alterations in the gut microbiome or systemic outcomes, a subset of animals on the HF diet were treated orally with 0.3 g/day (~ 7.5 × 108 CFU/day) of Winclove Ecologic® Barrier probiotics throughout the study.
Date:
February 9, 2022
Creator:
Phillippi, Danielle T.; Daniel, Sarah; Pusadkar, Vaidehi; Youngblood, Victoria L.; Nguyen, Kayla N.; Azad, Rajeev K. et al.
Object Type:
Article
System:
The UNT Digital Library
CancerNet: a unified deep learning network for pan‑cancer diagnostics
Article states that despite remarkable advances in cancer research, cancer remains one of the leading causes of death worldwide. The author's proposed framework for cancer diagnostics detects cancers and their tissues of origin using a unified model of cancers encompassing 33 cancers represented in The Cancer Genome Atlas. Their model exploits the learned features of different cancers reflected in the respective dysregulated epigenomes, holding a great promise in early cancer detection.
Date:
June 13, 2022
Creator:
Gore, Steven & Azad, Rajeev K.
Object Type:
Article
System:
The UNT Digital Library
Reconstructing horizontal gene flow network to understand prokaryotic evolution
Article says that horizontal gene transfer (HGT) is a major source of phenotypic innovation and a mechanism of niche adaptation in prokaryotes. Methods for detecting HGT can be classified into phylogenetic-based and parametric or composition-based approaches, so authors exploited the complementary strengths of both the approaches to construct a high confidence horizontal gene flow network. The scale-free horizontal gene flow network presented here provides new insights into modes of transfer for the exchange of genetic information and also illuminates differential gene flow across phyla.
Date:
November 30, 2022
Creator:
Sungupta, Soham & Azad, Rajeev K.
Object Type:
Article
System:
The UNT Digital Library
Lipidomic Analysis of Arabidopsis T-DNA Insertion Lines Leads to Identification and Characterization of C-Terminal Alterations in FATTY ACID DESATURASE 6
Article states that mass-spectrometry-based screening of lipid extracts of wounded and unwounded leaves from a collection of 364 Arabidopsis thaliana T-DNA insertion lines produced lipid profiles that were scored on the number and significance of their differences from the leaf lipid profiles of wild-type plants. The analysis identified Salk_109175C, which displayed alterations in leaf chloroplast glycerolipid composition, including a decreased ratio between two monogalactosyldiacylglycerol (MGDG) molecular species, MGDG(18:3/16:3) and MGDG(18:3/18:3).
Date:
June 21, 2022
Creator:
Lusk, Hannah J.; Neumann, Nicholas; Colter, Madeline; Roth, Mary R.; Tamura, Pamela; Yao, Libin et al.
Object Type:
Article
System:
The UNT Digital Library
Complete Genome Sequences of the Novel Cluster BP Phages Infecting Streptomyces sanglieri, AxeJC, Cumberbatch, Eastland, Eklok, HFrancette, Ignacio, Piccadilly, and Vondra
Article describes the Streptomyces sanglieri bacteriophages AxeJC, Cumberbatch, Eastland,Eklok, HFrancette, Ignacio, Piccadilly, and Vondra form a novel actinobacteriophage cluster,BP. These siphoviruses have circularly permuted genomes with an average size of 37,700 bp and a GC content of 71%. Each genome contains approximately 58 protein-coding genes, with no tRNAs.
Date:
September 14, 2022
Creator:
Nath, Sreemoye; Sulaiman, Ahmad; Maneekul, Jindanuch; Bhuiyan, Swapan; Layton, Sonya R.; Menchaca, Carolina et al.
Object Type:
Article
System:
The UNT Digital Library
Identification of Novel Antimicrobial Resistance Genes Using Machine Learning, Homology Modeling, and Molecular Docking
Article claims antimicrobial resistance (AMR) threatens the healthcare system worldwide with the rise of emerging drug resistant infectious agents. To infer novel resistance genes, we used complete gene sets of several bacterial strains known to be susceptible or resistant to specific drugs and associated phenotypic information within a machine learning framework that enabled prioritizing genes potentially involved in resistance.
Date:
October 23, 2022
Creator:
Sunuwar, Janak & Azad, Rajeev K.
Object Type:
Article
System:
The UNT Digital Library
Habitat amount or landscape configuration: Emerging HotSpot analysis reveals the importance of habitat amount for a grassland bird in South Dakota
The authors of the article used pheasants (Phasianus colchicus) across South Dakota, USA as a model species to identify environmental factors driving spatiotemporal variation in population productivity. They found that the amount of grassland at a local spatial scale was the primary factor influencing an area being a HotSpot.
Date:
September 26, 2022
Creator:
Harsh, Sprih; Lonsinger, Robert C. & Gregory, Andrew
Object Type:
Article
System:
The UNT Digital Library
Multi-omic characterization of bifunctional peroxidase 4-coumarate 3-hydroxylase knockdown in Brachypodium distachyon provides insights into lignin modification associated pleiotropic effects
Article discusses how a bifunctional peroxidase enzyme, 4-coumarate 3-hydroxylase (C3H/APX), provides a parallel route to the shikimate shunt pathway for the conversion of 4-coumarate to caffeate in the early steps of lignin biosynthesis. Here, a multi-omic approach was used to characterize molecular changes resulting from C3H/APX-KD associated lignin modification and negative growth phenotype in Brachypodium distachyon.
Date:
September 28, 2022
Creator:
Shrestha, Him K.; Fichman, Yosef; Engle, Nancy L.; Tschaplinski, Timothy J.; Mittler, Ron; Dixon, R. A. et al.
Object Type:
Article
System:
The UNT Digital Library
Editorial: Lipid metabolism and membrane structure in plant biotic interactions
Article discusses how Lipid bilayers represent the interface between cells (or organelles) and their environment. Authors claim that this special topic brings together new reports on several of these lipid classes to shed light on the impacts of plant lipid metabolism and membrane organization on plant immunity.
Date:
December 6, 2022
Creator:
Goggin, Fiona L.; Shah, Jyoti & Gillaspy, Glenda
Object Type:
Article
System:
The UNT Digital Library
A lipidomics platform to analyze the fatty acid compositions of non-polar and polar lipid molecular species from plant tissues: Examples from developing seeds and seedlings of pennycress (Thlaspi arvense)
Article describes a stepwise targeted lipidomics approach to characterize the polar and non-polar lipid classes using complementary LC-MS methods. This lipidomics workflow was applied to developing, mature, and germinated pennycress seeds/seedlings and found unexpected changes among several lipid molecular species.
Date:
November 9, 2022
Creator:
Romsdahl, Trevor B.; Cocuron, Jean-Christophe; Pearson, Mackenzie J.; Alonso, Ana Paula & Chapman, Kent Dean
Object Type:
Article
System:
The UNT Digital Library
Manipulating plasma thyroid hormone levels alters development of endothermy and ventilation in nestling red-winged blackbirds
Authors of the article propose that thyroid hormones play an important role in regulating development of endothermy during the nestling period in altricial birds. Their data suggests plasma thyroid hormone levels play an active role in the systemic development of endothermic capacity and the development of ventilatory control.
Date:
November 29, 2022
Creator:
Sirsat, Tushar S.; Sirsat, Sarah K. G.; Price, Edwan R.; Pineda, Megan & Dzialowski, Edward M. (Edward Michael)
Object Type:
Article
System:
The UNT Digital Library