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01-ERD-111 - The Development of Synthetic High Affinity Ligands
The aim of this project was to develop Synthetic High-Affinity Ligands (SHALs), which bind with high affinity and specificity to proteins of interest for national security and cancer therapy applications. The aim of producing synthetic ligands for sensory devices as an alternative to antibody-based detection assays and therapeutic agents is to overcome the drawbacks associated with antibody-based in next-generation sensors and systems. The focus area of the project was the chemical synthesis of the SHALs. The project concentrated on two different protein targets. (a) The C fragment of tetanus and botulinum toxin, potential biowarfare agents. A SHAL for tetanus or botulinum toxin would be incorporated into a sensory device for the toxins. (b) HLA-DR10, a protein found in high abundance on the surface of Non-Hodgkins Lymphoma. A SHAL specific to a tumor marker, labeled with a radionuclide, would enable the targeted delivery of radiation therapy to metastatic disease. The technical approach used to develop a SHAL for each protein target will be described in more detail below. However, in general, the development of a SHAL requires a combination of computational modeling techniques, modern nuclear magnetic resonance spectroscopy (NMR) and synthetic chemistry.
Date:
February 5, 2004
Creator:
Perkins, J; Balhorn, R; Cosman, M; Lightstone, F & Zeller, L
System:
The UNT Digital Library
9/11 Terrorism: Global Economic Costs
The 9/11 attacks were part of Al Qaeda’s strategy to disrupt Western economies and impose both direct and secondary costs on the United States and other nations. The immediate costs were the physical damage, loss of lives and earnings, slower world economic growth, and capital losses on stock markets. Indirect costs include higher insurance and shipping fees, diversion of time and resources away from enhancing productivity to protecting and insuring property, public loss of confidence, and reduced demand for travel and tourism. In a broader sense, the 9/11 attacks led to the invasions and occupations of Afghanistan and Iraq (and the Global War on Terrorism) and perhaps emboldened terrorists to attack in Bali, Spain, Morocco, and Saudi Arabia. A policy question for Congress is how to evaluate the costs and benefits of further spending to counter terrorism and its economic impact.
Date:
October 5, 2004
Creator:
Nanto, Dick K.
System:
The UNT Digital Library
10 CFR 850 Implementation of Requirements
10 CFR 850 defines a contractor as any entity, including affiliated entities, such as a parent corporation, under contract with DOE, including a subcontractor at any tier, with responsibility for performing work at a DOE site in furtherance of a DOE mission. The Chronic Beryllium Disease Prevention Program (CBDPP) applies to beryllium-related activities that are performed at the Lawrence Livermore National Laboratory (LLNL). The CBDPP or Beryllium Safety Program is integrated into the LLNL Worker Safety and Health Program and, thus, implementation documents and responsibilities are integrated in various documents and organizational structures. Program development and management of the CBDPP is delegated to the Environment, Safety and Health (ES&H) Directorate, Worker Safety and Health Functional Area. As per 10 CFR 850, Lawrence Livermore National Security, LLC (LLNS) periodically submits a CBDPP to the National Nuclear Security Administration/Livermore Site Office (NNSA/LSO). The requirements of this plan are communicated to LLNS workers through ES&H Manual Document 14.4, 'Working Safely with Beryllium.' 10 CFR 850 is implemented by the LLNL CBDPP, which integrates the safety and health standards required by the regulation, components of the LLNL Integrated Safety Management System (ISMS), and incorporates other components of the LLNL ES&H Program. As described in …
Date:
January 5, 2012
Creator:
Lee, S.
System:
The UNT Digital Library
N-17, A Delayed Neutron Emitter
The decay scheme of a 4.2 second neutron emitter has been investigated in detail. Chemical and physical evidence shows that it is N{sup 17}, which emits beta rays to a broad excited state of O{sup 17}, which then breaks up into a neutron plus O{sup 16}. The energy spectrum of the neutrons is determined by measuring the energies of the O{sup 16} recoils in a proportional counter. The neutrons have a most probable energy of 0.9 Mev, a 'half width' of less than .5 Mev, and an upper limit of about 2 Mev. {beta}-recoil coincidences are observed, as predicted by the Bohr-Wheeler theory, and the {beta}-ray energy is measured by absorption. The beta rays in coincidence with neutrons have an upper limit of 3.7 {+-} 0.2 Mev. Beta-rays directly to the ground stat of O{sup 17} are not observed because of high background effects, but should have an energy of 8.7 Mev. Some evidence is presented to show that energy is conserved in the {beta}-n transition through the broad excited state in O{sup 17}.
Date:
November 5, 1948
Creator:
Alvarez, L. W.
System:
The UNT Digital Library
17-keV x-ray output of plutonium
In the production of plutonium in a reactor, plutonium-238, 240, and 241 are formed as well as Pu{sup 239}. It is well known that the specific alpha activity of the plutonium varies as the percentages of these isotopes are changed. Kinderman, et al have worked out the relationship between isotopic content and MWD/ton exposure. Their findings are reported in this document.
Date:
November 5, 1958
Creator:
McCall, R. C. & Bernard, R. M.
System:
The UNT Digital Library
45-Day safety screen results for tank 241-U-202, push mode, cores 75 and 78
This document is a report of the analytical results for samples collected from the radioactive wastes in Tank 241-U-202 at the Hanford Reservation. Core samples were collected from the solid wastes in the tank and underwent safety screening analyses including differential scanning calorimetry, thermogravimetric analysis, and total alpha analysis. Results indicate that no safety screening notification limits were exceeded.
Date:
May 5, 1995
Creator:
Jo, J.
System:
The UNT Digital Library
45-Day safety screen results for tank 241-U-203, push mode, cores 79 and 80
Two one-segment core samples from tank 241-U-203 (U-203) were received by the 222-S Laboratories and underwent safety screening analysis, consisting of differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and total alpha activity. In addition to the safety screening requirements, inductively coupled plasma (ICP) spectrographic analysis for lithium was performed to determine the extent of hydrostatic head fluid contamination during the sampling event. No notification limits were exceeded for these analyses.
Date:
May 5, 1995
Creator:
Schreiber, R. D.
System:
The UNT Digital Library
60-day waste compatibility safety issues and final results for TX-244 grab samples
Three grab samples (244-TX-96-1, 244-TX-96-2, and 244-TX-96-3) were taken from Riser 8 of Tank 241-TX-244 on October 18, 1996, and received by 222-S Laboratory on October 18, 1996. These samples were analyzed in accordance with Compatibility Grab Sampling and Analysis Plan (TSAP) and Data Quality Objectives for Tank Farms Waste Compatibility Program (DQO) in support ofthe Waste Compatibility Program. Notifications were made in accordance with TSAP for pH and OH- analyses. Upon further review, the pH notification was deemed unnecessary, as the notification limit did not apply to this tank.
Date:
February 5, 1997
Creator:
Nuzum, J. L.
System:
The UNT Digital Library
100 Areas: (For technical progress letter No. 104), June 25--July 1
None
Date:
July 5, 1946
Creator:
Jordan, W. E.
System:
The UNT Digital Library
100 Areas technical activities report -- Engineering, October, 1949
This report covers work done by the Physical Chemistry Group and the Pile Engineering Groups. Subjects covered are as follows: corrosion laboratory testing details; pile borescopic inspections; slug deformation details; Van Stone flange corrosion details; corrosion rate at elevated temperature; added control ink facility; borescope equipment and repair; water recirculation cooling tests; pile expansion; carbon dioxide experiment; special graphite measurements; graphite core sample; vertical thimble temperature; beta experiment; x-ray diffraction studies; thermal annealing; empty process tube temperatures; oxidation of graphite; thermal annealing -- interferometer measurements.
Date:
December 5, 1949
Creator:
unknown
System:
The UNT Digital Library
105-K Basin Material Design Basis Feed Description for Spent Nuclear Fuel (SNF) Project Facilities VOL 2 Sludge
Volume 2 provides estimated chemical and radionuclide inventories of sludge currently stored within the Hanford Site's 105-K Basin This volume also provides estimated chemical and radionuclide inventories for the sludge streams expected to be generated during Spent Nuclear Fuel (SNF) Project activities.
Date:
April 5, 2000
Creator:
PEARCE, K.L.
System:
The UNT Digital Library
105 K West Cask Transportation Facility Modification Acceptance for Beneficial Use Checklist Project A.5 and A.6
The CTFM Subproject of the SNF Project has prepared an ABU checklist per SNF Administrative Procedure (AP) CS-6-019. This checklist identifies the essential documentation needed to operate and maintain the 105 KW CTFM/CLS Structures, Systems, and Components (SSCs) when ownership is transferred from the CTFM Subproject to K Basins Operations. Approval of this supporting document demonstrates an agreement by the approvers as to the documentation required at turnover.
Date:
May 5, 2000
Creator:
HARRIS, D.L.
System:
The UNT Digital Library
216-Day report for Tank 241-C-111, cores 58 and 59
Three core samples from tank C-111, and a field blank, were received by the 222-S laboratories. Cores 58, 59, and the field blank were analyzed in accordance with plans. A hot cell blank was analyzed at the direction of the hot cell chemist. No sample results exceeded the notification limits. Core 60 was not analyzed.
Date:
December 5, 1994
Creator:
Rice, A.D.
System:
The UNT Digital Library
241-Z-361 Sludge Characterization Sampling and Analysis Plan
This sampling and analysis plan (SAP) identifies the type, quantity, and quality of data needed to support characterization of the sludge that remains in Tank 241-2-361. The procedures described in this SAP are based on the results of the 241-2-361 Sludge Characterization Data Quality Objectives (DQO) (BWHC 1999) process for the tank. The primary objectives of this project are to evaluate the contents of Tank 241-2-361 in order to resolve safety and safeguards issues and to assess alternatives for sludge removal and disposal.
Date:
August 5, 1999
Creator:
BANNING, D.L.
System:
The UNT Digital Library
300 area TEDF NPDES Permit Compliance Monitoring Plan
This document presents the 300 Area Treated Effluent Disposal Facility (TEDF) National Pollutant Discharge Elimination System (NPDES) Permit Compliance Monitoring Plan (MP). The MP describes how ongoing monitoring of the TEDF effluent stream for compliance with the NPDES permit will occur. The MP also includes Quality Assurance protocols to be followed.
Date:
September 5, 1995
Creator:
Loll, C.M.
System:
The UNT Digital Library
327 legacy waste processing plan
The B and W Hanford Company`s (BWHC) 327 Facility [Postirradiation Testing Laboratory (PTL)] houses 10 hot cells in which a variety of postirradiation examinations have been performed since its construction in the mid 1950s. Over the years, the waste that was generated in these cells has been collected in one gallon buckets. These buckets are essentially one gallon cylindrical cans made of thin wall stainless steel with welded bottoms and slip fit lids. They contain assorted compactable waste (i.e., Wipe-Alls, Q-tips, towels, etc.) as well as non-compactable waste (i.e., small tools, pieces of metal tubing, etc.). There is a FY-98 BWHC Performance Agreement (PA) milestone in place to package 200 of these buckets in drums and ship them from the 327 facility to the Central Waste Complex (CWC) by September 30, 1998.
Date:
May 5, 1998
Creator:
Henderson, J. F.
System:
The UNT Digital Library
327 to 324 Pin tube shipment quality management process plan
The B and W Hanford Company's (BWHC) 327 Facility, in the 300 Area of the Hanford Site, is preparing to ship five Pin Tubes to the 324 Facility for storage and eventual disposition. The Pin Tubes consist of legacy fuel pin pieces and drillings. They will be over-packed in new Pin Tubes and transported to 324 in three shipments. Once received at 324, two of the shipments will be combined for storage as a fissionable material batch, and the other shipment will be added to an existing batch.
Date:
November 5, 1998
Creator:
HAM, J.E.
System:
The UNT Digital Library
600 MHz RF System for 200 BeV Accelerator
None
Date:
August 5, 1966
Creator:
Halama, H. J.
System:
The UNT Digital Library
1995 NPTS Databook
Policymakers rely on transportation statistics, including data on personal travel behavior, to formulate strategic transportation policies and to improve the safety and efficiency of the U.S. transportation system. Data on personal travel trends are needed to examine the reliability, efficiency, capacity, and flexibility of the Nation's transportation system to meet current demands and accommodate future demands; to assess the feasibility and efficiency of alternative congestion-alleviating technologies (e.g., high-speed rail, magnetically levitated trains, intelligent vehicle and highway systems); to evaluate the merits of alternative transportation investment programs; and to assess the energy-use and air-quality impacts of various policies. To address these data needs, the Department of Transportation (DOT) initiated an effort in 1969 to collect detailed data on personal travel. The 1969 survey was the first Nationwide Personal Transportation Survey (NPTS). The survey was conducted again in 1977, 1983, 1990, and 1995. The 1995 survey was cosponsored by four DOT agencies: Federal Highway Administration (FHWA), Bureau of Transportation Statistics (BTS), Federal Transit Administration (FTA), and National Highway Traffic Safety Administration (NHTSA). The primary objective of the survey was to collect trip-based data on the nature and characteristics of personal travel. Commercial and institutional travel were not part of the survey.
Date:
December 5, 2001
Creator:
Hu, P. S.
System:
The UNT Digital Library
1996-2004 Trends in the Single-Family Housing Market: Spatial Analysis of the Residential Sector
This report provides a detailed geographic analysis of two specific topics affecting the residential sector. First, we performed an analysis of new construction market trends using annual building permit data. We report summarized tables and national maps to help illustrate market conditions. Second, we performed a detailed geographic analysis of the housing finance market. We analyzed mortgage application data to provide citable statistics and detailed geographic summarization of the residential housing picture in the US for each year in the 1996-2004 period. The databases were linked to geographic information system tools to provide various map series detailing the results geographically. Looking at these results geographically may suggest potential new markets for TD programs addressing the residential sector that have not been considered previously. For example, we show which lenders affect which regions and which income or mortgage product classes. These results also highlight the issue of housing affordability. Energy efficiency R&D programs focused on developing new technology for the residential sector must be conscious of the costs of products resulting from research that will eventually impact the home owner or new home buyer. Results indicate that home values as a proportion of median family income in Building America communities are …
Date:
September 5, 2006
Creator:
Anderson, Dave M. & Elliott, Douglas B.
System:
The UNT Digital Library
2003 Pantex Plant Annual Illness and Injury Surveillance Report, Revised September 2007
Annual Illness and Injury Surveillance Program report for 2003 for the Pantex Plant. DOE is commited to assuring the health and safety of its workers. This includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. The IISP monitors illnesses and health conditions that result in an absence of workdays, occupational injuries and illnesses, and disabilities and deaths among current workers.
Date:
October 5, 2007
Creator:
United States. Department of Energy. Office of Illness and Injury Prevention Programs.
System:
The UNT Digital Library
2003 Savannah River Site Annual Illness and Injury Surveillance Report, Revised September 2007
Annual Illness and Injury Surveillance Program report for 2003 for the Savannah River Site. DOE is commitment to assuring the health and safety of its workers includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. The report monitors illnesses and health conditions that result in an absence of workdays, occupational injuries and illnesses, and disabilities and deaths among current workers.
Date:
October 5, 2007
Creator:
United States. Department of Energy. Office of Illness and Injury Prevention Programs.
System:
The UNT Digital Library
The 2004 Insurance Broker Investigations: An Overview
From Summary: This report briefly summarizes the events that occurred and the issues, they raised in regards to violations of state laws, against Marsh & McClennan Companies and Marsh, Inc, which the Attorney General of the Sate of New York filling a civil law suit.
Date:
November 5, 2004
Creator:
Webel, Baird
System:
The UNT Digital Library